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Text of the page (random words):
46947fe7k alfa 2b g8rgg88b68 y kegg d02748 y chembl chembl1201560 n chemical and physical data formula c 860 h 1353 n 227 o 255 s 9 molar mass 19 241 16 g mol 1 n y what is this verify pegylated interferon alfa 2a sold under the brand name pegasys among others is medication used to treat hepatitis c and hepatitis b 2 for hepatitis c it is typically used together with ribavirin and cure rates are between 24 and 92 2 3 for hepatitis b it may be used alone 4 it is given by injection under the skin 2 side effects are common 5 they may include headache feeling tired depression trouble sleeping hair loss nausea pain at the site of injection and fever 2 severe side effects may include psychosis autoimmune disorders blood clots or infections 2 use with ribavirin is not recommended during pregnancy 2 pegylated interferon alfa 2a is in the alpha interferon family of medications 2 it is pegylated to protect the molecule from breakdown 5 pegylated interferon alfa 2a was approved for medical use in the united states in 2002 2 it is on the world health organization s list of essential medicines 6 medical uses edit this drug is approved around the world for the treatment of chronic hepatitis c including people with hiv co infection cirrhosis normal levels of alt and has recently been approved in the eu u s china and many other countries for the treatment of chronic hepatitis b it is also used in the treatment of certain t cell lymphomas particularly mycosis fungoides citation needed additionally nccn guidelines recommend peginterferon alfa 2a as a potential option for treatment of several myeloproliferative neoplasms including essential thrombocythemia primary myelofibrosis and polycythemia vera particularly in young patients or instances where hydroxyurea is contraindicated such as pregnancy 7 peginterferon alfa 2a is a long acting interferon interferons are proteins released in the body in response to viral infections interferons are important for fighting viruses in the body for regulating reproduction of cells and for regulating the immune system 8 host genetic factors edit for genotype 1 hepatitis c treated with pegylated interferon alfa 2a or pegylated interferon alfa 2b combined with ribavirin it has been shown that genetic polymorphisms near the human il28b gene encoding interferon lambda 3 are associated with significant differences in response to the treatment this finding originally reported in nature 9 showed genotype 1 hepatitis c patients carrying certain genetic variant alleles near the il28b gene are more likely to achieve sustained virological response after the treatment than others another report in nature demonstrated the same genetic variants are also associated with the natural clearance of the genotype 1 hepatitis c virus 10 manufacturing edit it is pegylated with a branched 40 kg mol peg chain 11 availability edit peginterferon alfa 2a is manufactured under the brand name pegasys in 2021 roche pharmaceuticals sold the worldwide rights of pegasys excluding china and japan to zr pharma gmbh pharma 12 13 14 15 16 in may 2022 roche australia transferred the sales and marketing of pegasys to echo therapeutics pty ltd 17 research edit a cochrane review sought to determine whether interferon alfa 2a could be used as a treatment for individuals with neovascular age related macular degeneration they found no evidence of improved visual acuity with potential harm 18 references edit pegasys epar european medicines agency ema 20 june 2002 retrieved 5 september 2024 1 2 3 4 5 6 7 8 peginterferon alfa 2a professional patient advice drugs com archived from the original on 16 january 2017 retrieved 12 january 2017 pegasys 135 mcg and 180 mcg solution for injection in pre filled pen summary of product characteristics spc emc medicines org uk archived from the original on 13 january 2017 retrieved 12 january 2017 british national formulary bnf 69 69 ed british medical association 2015 p 639 isbn 978 0 85711 156 2 1 2 peginterferon alfa 2a pegasys treatment hepatitis c online hepatitisc uw edu archived from the original on 23 december 2016 retrieved 12 january 2017 world health organization 2019 world health organization model list of essential medicines 21st list 2019 geneva world health organization hdl 10665 325771 who mvp emp iau 2019 06 license cc by nc sa 3 0 igo national comprehensive cancer network myeloproliferative neoplasms version 2 2025 https www nccn org professionals physician_gls pdf mpn pdf accessed november 4th 2025 interferon alfa 2a uses side effects warnings drugs com retrieved 10 january 2020 ge d fellay j thompson aj et al 2009 genetic variation in il28b predicts hepatitis c treatment induced viral clearance nature 461 7262 399 401 bibcode 2009natur 461 399g doi 10 1038 nature08309 pmid 19684573 s2cid 1707096 thomas dl thio cl martin mp et al 2009 genetic variation in il28b and spontaneous clearance of hepatitis c virus nature 461 7265 798 801 bibcode 2009natur 461 798t doi 10 1038 nature08463 pmc 3172006 pmid 19759533 rajender reddy k modi mw pedder s june 2002 use of peginterferon alfa 2a 40 kd pegasys for the treatment of hepatitis c advanced drug delivery reviews 54 4 571 86 doi 10 1016 s0169 409x 02 00028 5 pmid 12052715 pegasys peginterferon alfa 2a genentech archived from the original on 8 january 2023 retrieved 8 january 2023 verzichtserklärung der zulassung mittelfristig läuft pegasys aus pdf in german roche archived from the original pdf on 4 december 2021 retrieved 4 december 2021 pegasys peginterferon alfa 2a langfristig weiterhin erhältlich pdf in german roche archived from the original pdf on 4 december 2021 retrieved 4 december 2021 pharma portfolio zr pharma gmbh retrieved 4 december 2021 half year report 2021 p 20 pdf roche archived from the original pdf on 24 november 2021 retrieved 4 december 2021 pegasys roche australia archived from the original on 8 january 2023 retrieved 8 january 2023 reddy u krzystolik m 2006 antiangiogenic therapy with interferon alfa for neovascular age related macular degeneration cochrane database of systematic reviews 1 1 cd005138 doi 10 1002 14651858 cd005138 pub2 pmc 12276864 pmid 16437522 external links edit wikimedia commons has media related to interferon alpha 2a pegasys at the u s national library of medicine medical subject headings mesh v t e cell signaling cytokines by family chemokine ccl ccl1 ccl2 mcp1 ccl3 mip1α ccl4 mip1β ccl5 rantes ccl6 ccl7 ccl8 ccl9 ccl11 ccl12 ccl13 ccl14 ccl15 ccl16 ccl17 ccl18 parc dcck1 amac1 mip4 ccl19 ccl20 ccl21 ccl22 ccl23 ccl24 ccl25 ccl26 ccl27 ccl28 cxcl cxcl1 kc cxcl2 cxcl3 cxcl4 cxcl5 cxcl6 cxcl7 cxcl8 il8 cxcl9 cxcl10 cxcl11 cxcl12 cxcl13 cxcl14 cxcl15 cxcl16 cxcl17 cx3cl cx3cl1 xcl xcl1 xcl2 tnf tnfa lymphotoxin tnfb lta tnfc ltb tnfsf4 tnfsf5 cd40lg tnfsf6 tnfsf7 tnfsf8 tnfsf9 tnfsf10 tnfsf11 tnfsf13 tnfsf13b eda interleukin type i grouped by receptor subunit γ chain il2 il15 il4 il13 il7 il9 il21 β chain il3 il5 gmcsf il6 like gp130 il6 il11 il27 il30 il31 non il osm lif cntf ctf1 il12 family il12rb1 il12 il23 il27 il35 other il14 il16 il32 il34 type ii il10 family il10 il22 il19 il20 il24 il26 interferon type iii il28 ifnl2 3 il29 ifnl1 interferon i ifna1 ifna2 ifna4 ifna5 ifna6 ifna7 ifna8 ifna10 ifna13 ifna14 ifna16 ifna17 ifna21 ifnb1 ifnk ifnw1 ii ifng ig superfamily il1 family il1a il1f1 il1b il1f2 1ra il1f3 il1f5 il1f6 il1f7 il1f8 il1f9 il1f10 33 il1f11 18 il1g il17 family il17 il25 il17a other hematopoietic kitlg colony stimulating factor spp1 mif by function cell proinflammatory cytokine il1 tnfa monokine lymphokine t h 1 ifnγ tnfβ t h 2 il4 il5 il6 il10 il13 category commons v t e immunostimulants l03 endogenous cytokines colony stimulating factors g csf efbemalenograstim alfa eflapegrastim filgrastim lipegfilgrastim pegfilgrastim lenograstim gm csf molgramostim sargramostim scf ancestim interferons alpha albinterferon interferon alfa natural interferon alfa 2a peginterferon alfa 2a interferon alfa 2b peginterferon alfa 2b ropeginterferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 feline omega beta interferon beta natural interferon beta 1a interferon beta 1b interferon gamma interleukins aldesleukin nogapendekin alfa inbakicept oprelvekin other protein peptide growth hormone immunocyanin pegademase prolactin tasonermin other female sex steroids histamine dihydrochloride poly iclc vitamin d exogenous beta glucan lentinan heterocyclic compound plerixafor hydroxyquinoline roquinimex mifamurtide oligopeptides glatiramer acetate thymopentin thymosin α1 thymulin polyribonucleotide polyinosinic polycytidylic acid thiazolidine pidotimod inosine pranobex vaccines bacillus calmette guérin melanoma vaccine sipuleucel t cridanimod v t e dna virus antivirals primarily j05 also s01ad and d06bb baltimore i herpesvirus dna synthesis inhibitor tk activated purine analogue guanine aciclovir valaciclovir ganciclovir valganciclovir penciclovir famciclovir adenine vidarabine pyrimidine analogue uridine idoxuridine trifluridine tipiracil edoxudine thymine brivudine fv 100 sorivudine not tk activated foscarnet other amenamevir docosanol letermovir maribavir early protein fomivirsen tromantadine hpv mc imiquimod resiquimod podophyllotoxin vaccinia assembly rifampicin poxviridae methisazone tecovirimat hepatitis b vii nucleoside analogues nartis entecavir lamivudine lobucavir telbivudine clevudine nucleotide analogues ntrtis adefovir tenofovir disoproxil tenofovir alafenamide multiple general nucleic acid inhibitors cidofovir brincidofovir interferon interferon alfa 2b peginterferon alfa 2a multiple unknown filociclovir ribavirin taribavirin moroxydine who em withdrawn from market clinical trials phase iii never to phase iii v t e rna virus antivirals primarily j05 also s01ad and d06bb hepatitis c ns3 4a protease inhibitors previr asunaprevir boceprevir ciluprevir danoprevir faldaprevir glecaprevir grazoprevir narlaprevir paritaprevir simeprevir sovaprevir telaprevir vaniprevir vedroprevir voxilaprevir ns5a inhibitors asvir coblopasvir daclatasvir elbasvir ledipasvir netanasvir odalasvir ombitasvir pibrentasvir ravidasvir ruzasvir samatasvir velpatasvir ns5b rna polymerase inhibitors buvir beclabuvir bemnifosbuvir dasabuvir deleobuvir encofosbuvir filibuvir gs 6620 idx 184 setrobuvir sofosbuvir tegobuvir tmc 647055 radalbuvir uprifosbuvir combination drugs elbasvir grazoprevir glecaprevir pibrentasvir ledipasvir sofosbuvir ombitasvir paritaprevir ritonavir sofosbuvir daclatasvir sofosbuvir velpatasvir sofosbuvir velpatasvir voxilaprevir hepatitis d bulevirtide picornavirus viral entry pleconaril anti influenza agents baloxavir marboxil onradivir pimodivir umifenovir adamantane derivatives m2 inhibitors adapromine amantadine rimantadine neuraminidase inhibitors release phase oseltamivir zanamivir peramivir laninamivir multiple general interferon interferon alfa 2b peginterferon alfa 2a peginterferon alfa 2b 3cl protease inhibitors trelvir atilotrelvir ensitrelvir ibuzatrelvir leritrelvir lufotrelvir nirmatrelvir ritonavir rupintrivir simnotrelvir ritonavir rna pol inhibitors cmx521 deuremidevir favipiravir galidesivir gs 441524 remdesivir mk 608 mericitabine molnupiravir nitd008 ribavirin taribavirin triazavirin valopicitabine multiple unknown other eicar merimepodib moroxydine presatovir who em withdrawn from market clinical trials phase iii never to phase iii v t e cytokine receptor modulators chemokine see here instead csf erythropoietin agonists ara 290 asialo erythropoietin carbamylated erythropoietin cnto 530 darbepoetin alfa epoetin alfa epoetin beta epoetin delta epoetin epsilon epoetin gamma epoetin kappa epoetin omega epoetin theta epoetin zeta erythropoietin epo erythropoietin fc methoxy polyethylene glycol epoetin beta cera mircera peginesatide pegol sihematide epo 018b g csf csf3 agonists filgrastim granulocyte colony stimulating factor lenograstim leridistim lipegfilgrastim nartograstim pegfilgrastim pegnartograstim gm csf csf2 agonists ecogramostim granulocyte macrophage colony stimulating factor milodistim molgramostim regramostim sargramostim antibodies mavrilimumab namilumab otilimab m csf csf1 agonists cilmostim interleukin 34 lanimostim macrophage colony stimulating factor mirimostim kinase inhibitors agerafenib scf c kit see here instead thrombopoietin agonists eltrombopag pegacaristim promegapoietin romiplostim avatrombopag lusutrombopag thrombopoietin thpo mgdf interferon ifnar α β i agonists albinterferon interferon alpha interferon alfa ifn α interferon alfa ifna1 ifna2 ifna4 ifna5 ifna6 ifna7 ifna8 ifna10 ifna13 ifna14 ifna16 ifna17 ifna21 interferon alfa 2a interferon alfa 2b interferon alfa n1 interferon alfacon 1 interferon alpha n3 interferon beta ifn β ifnb1 ifnb3 interferon beta 1a interferon beta 1b interferon kappa ifn ε κ τ ζ ifnk interferon omega ifn ω ifnw1 peginterferon alfa 2a peginterferon alfa 2b antibodies anifrolumab faralimomab medi 545 rontalizumab sifalimumab decoy receptors bifarcept ifngr γ ii agonists interferon gamma ifn γ interferon gamma 1b antibodies emapalumab fontolizumab ifnlr λ iii see il 28r ifnlr here instead interleukin see here instead tgfβ see here instead tnf see here instead others jak inhibitors jak1 abrocitinib baricitinib deuruxolitinib filgotinib momelotinib oclacitinib peficitinib ruxolitinib tofacitinib tasocitinib upadacitinib jak2 atiprimod azd 1480 baricitinib chz868 cucurbitacin i elatericin b jsi 124 cyt387 deuruxolitinib lestaurtinib nsc 7908 nsc 33994 pacritinib peficitinib ruxolitinib sd 1008 tofacitinib tasocitinib jak3 cercosporamide decernotinib vx 509 peficitinib ritlecitinib tcs 21311 tofacitinib tasocitinib whi p 154 zm 39923 zm 449829 tyk2 deucravacitinib others additional cytokines cardiotrophin 1 ct 1 fms like tyrosine kinase 3 ligand flt3l leukemia leukocyte inhibitory factor lif oncostatin m osm thymic stromal lymphopoietin tslp additional cytokine receptor modulators emfilermin lestaurtinib midostaurin quizartinib sorafenib sunitinib portals medicine viruses authority control databases national czech republic retrieved from https en wikipedia org w index php title peginterferon_alfa 2a oldid 1335559740 categories cyp1a2 inhibitors antiviral drugs immunostimulants world health organization essential medicines drugs developed by hoffmann la roche drugs developed by genentech withdrawn drugs hidden categories articles with short description short description matches wikidata use dmy dates from march 2024 short description is different from wikidata drugs with non standard legal status chemicals that do not have a chemspider id assigned articles with changed ebi identifier infobox drug articles without a structure image articles without inchi source multiple chemicals in infobox drug chemicals using indexlabels chemical articles with multiple cas registry numbers drugboxes which contain changes to verified fields cs1 vancouver names with accept markup all articles with unsourced 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