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siglec7 wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 references 2 further reading 3 external links toggle the table of contents siglec7 4 languages cymraeg русский татарча tatarça українська edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia protein coding gene in the species homo sapiens siglec7 identifiers aliases siglec7 airm1 cd328 cdw328 d siglec qa79 siglec 7 siglec19p siglecp2 p75 p75 airm1 sialic acid binding ig like lectin 7 airm 1 external ids omim 604410 mgi 1932475 genecards siglec7 available structures pdb ortholog search pdbe rcsb list of pdb id codes 1nko 1o7s 1o7v 2df3 2g5r 2hrl gene location human chr chromosome 19 human 1 band 19q13 41 start 51 142 299 bp 1 end 51 153 526 bp 1 gene location mouse chr chromosome 7 mouse 2 band 7 b3 7 start 43 300 494 bp 2 end 43 309 585 bp 2 rna expression pattern bgee human mouse ortholog top expressed in granulocyte monocyte blood spleen gonad testicle appendix amniotic fluid lymph node right adrenal cortex top expressed in granulocyte zygote secondary oocyte spleen blood embryo embryo right kidney bone marrow primary oocyte more reference expression data biogps more reference expression data gene ontology molecular function carbohydrate binding signaling receptor activity cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane biological process cell adhesion regulation of immune response signal transduction sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 27036 83382 ensembl ensg00000168995 ensmusg00000030474 uniprot q9y286 q91y57 refseq mrna nm_001277201 nm_014385 nm_016543 nm_031181 refseq protein np_001264130 np_055200 np_057627 np_112458 location ucsc chr 19 51 14 51 15 mb chr 7 43 3 43 31 mb pubmed search 3 4 wikidata view edit human view edit mouse sialic acid binding ig like lectin 7 is a protein that in humans is encoded by the siglec7 gene 5 6 siglec7 has also been designated as cd328 cluster of differentiation 328 references edit 1 2 3 grch38 ensembl release 89 ensg00000168995 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000030474 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine nicoll g ni j liu d klenerman p munday j dubock s mattei mg crocker pr dec 1999 identification and characterization of a novel siglec siglec 7 expressed by human natural killer cells and monocytes j biol chem 274 48 34089 95 doi 10 1074 jbc 274 48 34089 pmid 10567377 entrez gene siglec7 sialic acid binding ig like lectin 7 further reading edit reif k buday l downward j cantrell da 1994 sh3 domains of the adapter molecule grb2 complex with two proteins in t cells the guanine nucleotide exchange protein sos and a 75 kda protein that is a substrate for t cell antigen receptor activated tyrosine kinases j biol chem 269 19 14081 7 doi 10 1016 s0021 9258 17 36757 1 pmid 8188688 falco m biassoni r bottino c et al 1999 identification and molecular cloning of p75 airm1 a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells j exp med 190 6 793 802 doi 10 1084 jem 190 6 793 pmc 2195632 pmid 10499918 ye x mehlen p rabizadeh s et al 1999 traf family proteins interact with the common neurotrophin receptor and modulate apoptosis induction j biol chem 274 42 30202 8 doi 10 1074 jbc 274 42 30202 pmid 10514511 vitale c romagnani c falco m et al 2000 engagement of p75 airm1 or cd33 inhibits the proliferation of normal or leukemic myeloid cells proc natl acad sci u s a 96 26 15091 6 doi 10 1073 pnas 96 26 15091 pmc 24778 pmid 10611343 angata t varki a 2000 siglec 7 a sialic acid binding lectin of the immunoglobulin superfamily glycobiology 10 4 431 8 doi 10 1093 glycob 10 4 431 pmid 10764831 ito a handa k withers da et al 2001 binding specificity of siglec7 to disialogangliosides of renal cell carcinoma possible role of disialogangliosides in tumor progression febs lett 498 1 116 20 bibcode 2001febsl 498 116i doi 10 1016 s0014 5793 01 02476 0 pmid 11389909 s2cid 6755832 mingari mc vitale c romagnani c et al 2001 regulation of myeloid cell proliferation and survival by p75 airm1 and cd33 surface receptors progress in basic and clinical immunology advances in experimental medicine and biology vol 495 pp 55 61 doi 10 1007 978 1 4615 0685 0_8 isbn 978 1 4613 5194 8 pmid 11774609 yousef gm ordon mh foussias g diamandis ep 2002 genomic organization of the siglec gene locus on chromosome 19q13 4 and cloning of two new siglec pseudogenes gene 286 2 259 70 doi 10 1016 s0378 1119 02 00432 8 pmid 11943481 alphey ms attrill h crocker pr van aalten dm 2003 high resolution crystal structures of siglec 7 insights into ligand specificity in the siglec family j biol chem 278 5 3372 7 doi 10 1074 jbc m210602200 pmid 12438315 strausberg rl feingold ea grouse lh et al 2003 generation and initial analysis of more than 15 000 full length human and mouse cdna sequences proc natl acad sci u s a 99 26 16899 903 bibcode 2002pnas 9916899m doi 10 1073 pnas 242603899 pmc 139241 pmid 12477932 nicoll g avril t lock k et al 2003 ganglioside gd3 expression on target cells can modulate nk cell cytotoxicity via siglec 7 dependent and independent mechanisms eur j immunol 33 6 1642 8 doi 10 1002 eji 200323693 pmid 12778482 s2cid 7541832 dimasi n moretta a moretta l et al 2004 structure of the saccharide binding domain of the human natural killer cell inhibitory receptor p75 airm1 acta crystallogr d 60 pt 2 401 3 doi 10 1107 s0907444903028439 pmid 14747738 ikehara y ikehara sk paulson jc 2004 negative regulation of t cell receptor signaling by siglec 7 p70 airm and siglec 9 j biol chem 279 41 43117 25 doi 10 1074 jbc m403538200 pmid 15292262 avril t floyd h lopez f et al 2005 the membrane proximal immunoreceptor tyrosine based inhibitory motif is critical for the inhibitory signaling mediated by siglecs 7 and 9 cd33 related siglecs expressed on human monocytes and nk cells j immunol 173 11 6841 9 doi 10 4049 jimmunol 173 11 6841 pmid 15557178 yamaji t mitsuki m teranishi t hashimoto y 2005 characterization of inhibitory signaling motifs of the natural killer cell receptor siglec 7 attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs glycobiology 15 7 667 76 doi 10 1093 glycob cwi048 pmid 15703304 attrill h takazawa h witt s et al 2006 the structure of siglec 7 in complex with sialosides leads for rational structure based inhibitor design biochem j 397 2 271 8 doi 10 1042 bj20060103 pmc 1513286 pmid 16623661 rapoport em pazynina gv sablina ma et al 2006 probing sialic acid binding ig like lectins siglecs with sulfated oligosaccharides biochemistry mosc 71 5 496 504 doi 10 1134 s0006297906050051 pmid 16732727 s2cid 11537303 biedermann b gil d bowen dt crocker pr 2007 analysis of the cd33 related siglec family reveals that siglec 9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors leuk res 31 2 211 20 doi 10 1016 j leukres 2006 05 026 pmid 16828866 v t e pdb gallery 1nko energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75 airm1 or siglec 7 1o7s high resolution structure of siglec 7 1o7v high resolution structure of siglec 7 2df3 the structure of siglec 7 in complex with alpha 2 3 alpha 2 6 disialyl lactotetraosyl 2 trimethylsilyl ethyl 2g5r crystal structure of siglec 7 in complex with methyl 9 aminooxalyl amino 9 deoxyneu5ac oxamido neu5ac 2hrl siglec 7 in complex with gt1b external links edit siglec7 protein human at the u s national library of medicine medical subject headings mesh this article incorporates text from the united states national library of medicine which is in the public domain v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 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