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molecular breast imaging wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 mechanism 2 procedure 3 equipment 4 clinical indications 5 see also 6 references 7 external links toggle the table of contents molecular breast imaging add languages add links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia redirected from scintimammography medical diagnostic method scintimammography mammography left and dmsa scintimammography right images of 4 5cm breast carcinoma synonyms nuclear medicine breast imaging breast specific gamma imaging breast scintigraphy molecular breast imaging icd 10 pcs ch1 icd 9 cm 92 19 hcpcs l2 s8080 molecular breast imaging mbi also known as scintimammography is a type of breast imaging test that is used to detect cancer cells in breast tissue of individuals who have had abnormal mammograms especially for those who have dense breast tissue post operative scar tissue or breast implants 1 mbi is not used for screening or in place of a mammogram rather it is used when the detection of breast abnormalities is not possible or not reliable on the basis of mammography and ultrasound alone when mammography plus ultrasound are insufficient to characterize an abnormality the gold standard next step is magnetic resonance imaging mri of the breast however in patients with contraindications e g certain implantable devices or who prefer to avoid mri claustrophobia discomfort use of scintimammography is an acceptable alternative 2 1 mechanism edit scintiamammorgraphy is based on the principle of scintigraphy where the gamma radiation emitted from injected radiopharmaceuticals is measured by gamma cameras cancer cells take up radiopharmaceutical at a higher rate than surrounding normal tissue and as such they show up on scintigraphy as areas of increases gamma radiation emission a limitation to this principle is that not all breast lesions with metabolic activity higher than background are cancerous eg fibroadenoma and as such judicious use of molecular breast imaging by breast imagers is required 3 the most common radiopharmaceutical used in mbi is 99m tc sestamibi with doses of 240 300 mbq in current protocols resulting in an effective dose to a patient of around 2 4 msv earlier iterations of mbi required much higher doses of radiation up to 1100 mbq which in part led to mbi falling out of favor in the latter part of the last century however advances in gamma camera technology such as breast specific gamma imaging bsgi have allowed for quality resolution at much lower radiation doses and as such there has been increasing use of mbi 1 3 4 molecular breast imaging added to screening mammogram increases cancer detection rate by about 7 16 positive results per 1000 tests completed however the dose of radiation experienced by the patient is increased 1 3 4 5 6 procedure edit the procedure is conducted according to practice guidelines corresponding to the region where they are performed american college of radiology guidelines in the u s a patient can expect to receive an injection of radiopharmaceutical agent intravenously in the arm contralateral to the breast under investigation after waiting 5 10 minutes the breast tissue is placed into the mbi system and a series of images are obtained imaging time for both breasts is approximately 40 minutes for lesions identifiable on mbi but not mammography or ultrasound mbi guided biopsy is appropriate 3 7 equipment edit breast specific gamma cameras have been developed with a smaller field of view than conventional cameras allowing higher resolution imagery and compression of the breast as in x ray mammography which improves detection of smaller lesions 8 9 clinical indications edit mammography is widely accepted as the first line screening option for the detection of breast cancer with a sensitivity for detection of cancer at around 85 90 however in patients with dense breast tissue or those with risk of breast cancer greater than 20 the sensitivity of mammography drops significantly with some studies reporting a sensitivity of less than 50 3 in these patients many centers utilize breast ultrasound as additional screening modality which studies have shown increases breast cancer detection by 2 cancers detected per 1000 people screened 6 ultrasound also plays an important role in further characterization of indeterminate lesions seen on screening mammography but it does result in a significant increase in false positive rate when compared to mammography alone 6 10 breast mri is considered the gold standard in supplemental imaging of dense breasts with an increase in cancer detection of about 15 cancers per 1000 screens in patients where mri is contraindicated certain implantable devices certain kidney conditions or in those who prefer to avoid mri claustrophobia molecular breast imaging is a viable alternative mbi has shown to increase detection of breast cancer in dense breasts by 7 16 cancers per 1000 screens 1 3 5 see also edit technetium 99mtc sestamibi nuclear medicine positron emission mammography references edit 1 2 3 4 5 muzahir saima december 2020 molecular breast cancer imaging in the era of precision medicine american journal of roentgenology 215 6 1512 1519 doi 10 2214 ajr 20 22883 issn 0361 803x pmid 33084364 s2cid 224823965 monticciolo debra l newell mary s moy linda niell bethany monsees barbara sickles edward a march 2018 breast cancer screening in women at higher than average risk recommendations from the acr journal of the american college of radiology 15 3 408 414 doi 10 1016 j jacr 2017 11 034 issn 1546 1440 pmid 29371086 1 2 3 4 5 6 patel miral m adrada beatriz elena fowler amy m rauch gaiane m october 2023 molecular breast imaging and positron emission mammography pet clinics 18 4 487 501 doi 10 1016 j cpet 2023 04 005 issn 1556 8598 pmid 37258343 s2cid 258985887 1 2 dibble elizabeth h hunt katie n ehman eric c o connor michael k august 2020 molecular breast imaging in clinical practice american journal of roentgenology 215 2 277 284 doi 10 2214 ajr 19 22622 issn 0361 803x pmid 32551908 s2cid 219920040 1 2 molecular breast imaging society of nuclear medicine and molecular imaging retrieved 15 oct 2023 1 2 3 huppe ashley i mehta anita k brem rachel f 2018 02 01 molecular breast imaging a comprehensive review seminars in ultrasound ct and mri breast imaging state of the art 39 1 60 69 doi 10 1053 j sult 2017 10 001 issn 0887 2171 pmid 29317040 acr practice parameter for the performance of molecular breast imaging mbi using a dedicated gamma camera american college of radiology 2022 retrieved oct 15 2022 fass leonard august 2008 imaging and cancer a review molecular oncology 2 2 115 152 doi 10 1016 j molonc 2008 04 001 pmc 5527766 pmid 19383333 goldsmith s j parsons w guiberteau m j stern l h lanzkowsky l weigert j heston t f jones e buscombe j stabin m g 5 november 2010 snm practice guideline for breast scintigraphy with breast specific γ cameras 1 0 journal of nuclear medicine technology 38 4 219 224 doi 10 2967 jnmt 110 082271 pmid 21057112 mann ritse m athanasiou alexandra baltzer pascal a t camps herrero julia clauser paola fallenberg eva m forrai gabor fuchsjäger michael h helbich thomas h killburn toppin fleur lesaru mihai panizza pietro pediconi federica pijnappel ruud m pinker katja 2022 06 01 breast cancer screening in women with extremely dense breasts recommendations of the european society of breast imaging eusobi european radiology 32 6 4036 4045 doi 10 1007 s00330 022 08617 6 issn 1432 1084 pmc 9122856 pmid 35258677 external links edit scintimammography entry in the public domain nci dictionary of cancer terms this article incorporates public domain material from dictionary of cancer terms u s national cancer institute v t e tests and procedures involving the breast breast surgery breast conserving surgery lumpectomy segmental resection wide local excision quadrantectomy mastectomy radical mastectomy breast augmentation trans umbilical breast augmentation mammaplasty breast implant breast reduction spair mastopexy breast reconstruction interventions on the lactiferous ducts ductal lavage ductoscopy microdochectomy central duct excision breast imaging mammography positron emission mammography tomosynthesis xeromammography galactography breast mri breast ultrasound automated whole breast ultrasound scintimammography elastography other breast biopsy fine needle aspiration breast cancer screening breast self examination ductal lavage breast duct endoscopy v t e medical imaging x ray radiography 2d pneumoencephalography dental radiography sialography myelography cxr bronchography axr kub dxa dxr upper gastrointestinal series small bowel follow through lower gastrointestinal series cholangiography cholecystography mammography pyelogram cystography arthrogram hysterosalpingography skeletal survey angiography angiocardiography aortography venography lymphogram orbital x ray ct scan techniques general operation quantitative high resolution x ray microtomography electron beam cone beam proton targets heart calcium scan angiography abdominal and pelvis virtual colonoscopy angiography coronary pulmonary head thyroid whole body imaging full body ct scan other fluoroscopy dental panoramic radiography x ray motion analysis hounsfield scale radiodensity g arm mri brain functional neurography cardiac perfusion angiography cholangiopancreatography mrcp breast sequences diffusion restriction tractography synthetic mri ultrasound techniques doppler contrast enhanced 3d endoscopic duplex echocardiography doppler echocardiography tte tee ice transcranial doppler intravascular gynecologic obstetric echoencephalography abdominal ultrasonography liver tumors renal renal tract rectal breast scrotal carotid emergency ultrasound fast pre hospital radionuclide 2d scintigraphy cholescintigraphy scintimammography ventilation perfusion scan radionuclide ventriculography radionuclide angiography radioisotope renography sestamibi parathyroid scintigraphy radioactive iodine uptake test bone scintigraphy immunoscintigraphy dacryoscintigraphy dmsa scan gastric emptying study full body octreotide scan gallium 67 scan ga 68 dotatoc indium 111 wbc scan 3d ect spect gamma ray myocardial perfusion imaging pet positron brain pet cardiac pet pet mammography pet ct pet mri optical laser optical tomography optical coherence tomography confocal microscopy endomicroscopy orthogonal polarization spectral imaging thermography non contact thermography contact thermography dynamic angiothermography target conditions acute stroke pregnancy category retrieved from https en wikipedia org w index php title molecular_breast_imaging oldid 1291853495 categories 2d nuclear medical imaging breast imaging cancer screening hidden categories articles with short description short description is different from wikidata wikipedia articles incorporating text from the national cancer institute dictionary of cancer terms this page was last edited on 23 may 2025 at 20 05 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization 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