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skraup reaction wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 mechanism 2 see also 3 references toggle the table of contents skraup reaction 15 languages azərbaycanca čeština deutsch español فارسی français հայերեն 日本語 кыргызча nederlands română slovenčina தமிழ் українська 中文 edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia chemical reaction used to synthesize quinolines skraup reaction named after zdenko hans skraup reaction type ring forming reaction identifiers rsc ontology id rxno 0000062 the skraup reaction or skraup synthesis is a chemical reaction used to synthesize quinolines it is named after the czech chemist zdenko hans skraup 1850 1910 in the archetypal skraup reaction aniline is heated with sulfuric acid glycerol and an oxidizing agent such as nitrobenzene to yield quinoline 1 2 3 4 the skraup reaction in this example nitrobenzene serves as both the solvent and the oxidizing agent the reaction which otherwise has a reputation for being violent is typically conducted in the presence of ferrous sulfate 5 arsenic acid may be used instead of nitrobenzene and the former is better since the reaction is less violent 6 mechanism edit see also edit bischler napieralski reaction doebner miller reaction references edit skraup z h 1880 eine synthese des chinolins berichte 13 2086 manske r h f 1942 the chemistry of quinolines chem rev 30 113 144 doi 10 1021 cr60095a006 manske richard h f kulka marshall 1953 the skraup synthesis of quinolines org react 7 80 99 doi 10 1002 0471264180 or007 02 isbn 0471264180 cite journal isbn date incompatibility help cs1 maint periodical has isbn link wahren m 1964 stabilisotop markierte verbindungen ii untersuchung der skraupschen chinolin synthese mit hilfe von 15n tetrahedron 20 12 2773 doi 10 1016 s0040 4020 01 98495 9 clarke h t davis a w 1941 quinoline organic syntheses cite journal cs1 maint multiple names authors list link collected volumes vol 1 p 478 finar ivor lionel 1973 organic chemistry volume 1 6th ed longman p 857 isbn 978 0582442214 retrieved from https en wikipedia org w index php title skraup_reaction oldid 1363413340 categories condensation reactions quinoline forming reactions name reactions hidden categories articles with short description short description is different from wikidata cs1 errors isbn date cs1 maint periodical has isbn cs1 maint multiple names authors list this page was last edited on 10 july 2026 at 01 23 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents skraup reaction 15 languages add topic