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Text of the page (random words):
s each inward rectifier potassium channel α subunit is composed of two transmembrane α helices a pore helix and a potassium ion selectivity filter sequence and assembles into a tetramer forming the complete channel 3 the two pore domain potassium channels instead are dimers where each subunit is essentially two α subunits joined together 4 each single channel does not have two pores the name of the channel comes from the fact that each subunit has two p pore domains in its primary sequence 5 to quote rang and dale 2015 the nomenclature is misleading especially when they are incorrectly referred to as two pore channels 6 a decrease in these leak channels activity is known as channel arrest which reduces oxygen consumption 7 and allows animals to survive anoxia 8 below is a list of the 15 known two pore domain human potassium channels 1 gene channel 9 family aliases kcnk1 k 2p 1 1 twik 2 10 twik 1 kcnk2 k 2p 2 1 trek 2 10 trek 1 kcnk3 k 2p 3 1 task 2 10 task 1 kcnk4 k 2p 4 1 trek 2 10 traak 11 kcnk5 k 2p 5 1 task 2 10 task 2 12 kcnk6 k 2p 6 1 twik 2 10 twik 2 kcnk7 k 2p 7 1 twik 2 10 kcnk9 k 2p 9 1 task 2 10 task 3 kcnk10 k 2p 10 1 trek 2 10 trek 2 kcnk12 k 2p 12 1 thik thik 2 kcnk13 k 2p 13 1 thik thik 1 kcnk15 k 2p 15 1 task 2 10 task 5 kcnk16 k 2p 16 1 talk 2 10 talk 1 kcnk17 k 2p 17 1 talk 2 10 talk 2 task 4 kcnk18 k 2p 18 1 trik tresk 2 10 13 14 k2p1 human k2p1 pdb 3ukm identifiers symbol k2p1 hgnc 6272 refseq np_002236 1 uniprot o00180 search for structures swiss model domains interpro k2p2 human k2p2 pdb 4twk identifiers symbol k2p2 hgnc 6277 refseq np_055032 1 uniprot o95069 search for structures swiss model domains interpro k2p3 human k2p3 pdb 6rv3 identifiers symbol k2p3 hgnc 6278 refseq np_002237 1 uniprot o14649 search for structures swiss model domains interpro see also edit ion channel potassium channel references edit 1 2 goldstein sa bayliss da kim d lesage f plant ld rajan s december 2005 international union of pharmacology lv nomenclature and molecular relationships of two p potassium channels pharmacological reviews 57 4 527 540 doi 10 1124 pr 57 4 12 pmid 16382106 s2cid 7356601 1 2 3 4 5 6 7 8 9 10 11 12 13 14 enyedi p czirják g april 2010 molecular background of leak k currents two pore domain potassium channels physiological reviews 90 2 559 605 doi 10 1152 physrev 00029 2009 pmid 20393194 doyle da morais cabral j pfuetzner ra kuo a gulbis jm cohen sl et al april 1998 the structure of the potassium channel molecular basis of k conduction and selectivity science 280 5360 69 77 bibcode 1998sci 280 69d doi 10 1126 science 280 5360 69 pmid 9525859 miller an long sb january 2012 crystal structure of the human two pore domain potassium channel k2p1 science 335 6067 432 436 bibcode 2012sci 335 432m doi 10 1126 science 1213274 pmid 22282804 s2cid 206537279 baggetta am bayliss da czirják g enyedi p goldstein sa lesage f minor jr dl plant ld sepúlveda f two p domain potassium channels gtopdb v 2023 1 iuphar bps guide to pharmacology retrieved 2019 05 28 rang hp 2003 pharmacology 8 ed edinburgh churchill livingstone p 59 isbn 978 0 443 07145 4 lutz peter l milton sarah l 2004 08 15 negotiating brain anoxia survival in the turtle journal of experimental biology 207 18 3141 3147 bibcode 2004jexpb 207 3141l doi 10 1242 jeb 01056 issn 1477 9145 pmid 15299035 welker alexis f moreira daniel c campos élida g hermes lima marcelo august 2013 role of redox metabolism for adaptation of aquatic animals to drastic changes in oxygen availability comparative biochemistry and physiology part a molecular integrative physiology 165 4 384 404 doi 10 1016 j cbpa 2013 04 003 pmid 23587877 gutman ga chandy kg adelman jp aiyar j bayliss da clapham de et al december 2003 international union of pharmacology xli compendium of voltage gated ion channels potassium channels pharmacological reviews 55 4 583 586 doi 10 1124 pr 55 4 9 pmid 14657415 s2cid 34963430 1 2 3 4 5 6 7 8 9 10 11 12 13 lotshaw dp 2007 biophysical pharmacological and functional characteristics of cloned and native mammalian two pore domain k channels cell biochemistry and biophysics 47 2 209 256 doi 10 1007 s12013 007 0007 8 pmid 17652773 s2cid 12759521 fink m lesage f duprat f heurteaux c reyes r fosset m lazdunski m june 1998 a neuronal two p domain k channel stimulated by arachidonic acid and polyunsaturated fatty acids the embo journal 17 12 3297 3308 doi 10 1093 emboj 17 12 3297 pmc 1170668 pmid 9628867 goldstein sa bockenhauer d o kelly i zilberberg n march 2001 potassium leak channels and the kcnk family of two p domain subunits nature reviews neuroscience 2 3 175 184 doi 10 1038 35058574 pmid 11256078 s2cid 9682396 sano y inamura k miyake a mochizuki s kitada c yokoi h et al july 2003 a novel two pore domain k channel tresk is localized in the spinal cord the journal of biological chemistry 278 30 27406 27412 doi 10 1074 jbc m206810200 pmid 12754259 czirják g tóth ze enyedi p april 2004 the two pore domain k channel tresk is activated by the cytoplasmic calcium signal through calcineurin the journal of biological chemistry 279 18 18550 18558 doi 10 1074 jbc m312229200 pmid 14981085 external links edit tandem pore domain potassium channel at the u s national library of medicine medical subject headings mesh two p potassium channels iuphar database of receptors and ion channels international union of basic and clinical pharmacology v t e membrane transport protein ion channels tc 1a ca 2 calcium channel ligand gated inositol trisphosphate receptor 1 2 3 ryanodine receptor 1 2 3 voltage gated l type ca v α 1 1 1 2 1 3 1 4 n type ca v α2 2 p type ca v α 2 1 q type ca v α2 1 r type ca v α2 3 t type ca v α 3 1 3 2 3 3 α 2 δ subunits 1 2 β subunits β1 β2 β3 β4 γ subunits γ1 γ2 γ3 γ4 cation channels of sperm 1 2 3 4 two pore channel 1 2 na sodium channel constitutively active epithelial sodium channel α β γ δ proton gated amiloride sensitive cation channel 1 2 3 4 voltage gated na v α 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 7a na v β 1 2 3 4 k potassium channel calcium activated bk channel α1 β1 β2 β3 β4 sk channel sk1 sk2 sk3 ik channel ik1 k ca 1 1 2 1 2 2 2 3 3 1 4 1 4 2 5 1 inward rectifier k atp k ir 1 1 2 1 2 2 2 3 2 4 2 6 girk k ir 3 1 3 2 3 3 3 4 k ir 4 1 4 2 5 1 6 1 6 2 7 1 tandem pore domain k2p 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18 voltage gated k v α1 6 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 2 1 2 2 3 1 3 2 3 3 3 4 4 1 4 2 4 3 5 1 6 1 6 2 6 3 6 4 k v α7 12 7 1 7 2 7 3 7 4 7 5 8 1 8 2 9 1 9 2 9 3 10 1 10 2 11 1 herg 11 2 11 3 12 1 12 2 12 3 k v β 1 2 3 kcnip 1 2 3 4 mink isk mink isk like mirp 1 2 3 shaker gene miscellaneous cl chloride channel calcium dependent chloride channels anoctamin ano1 bestrophin 1 2 chloride channel accessory 1 2 3 4 cftr clcn 1 2 3 4 5 6 7 ka kb clic 1 2 3 4 5 6 l1 clns 1a 1b h proton channel hvcn1 m cng cation channel α 1 2 3 4 β 1 2 3 hcn fc 1 2 3 4 m trp cation channel trpa 1 trpc 1 2 3 4 4ap 5 6 7 trpm 1 2 3 4 5 6 7 8 trpml 1 2 3 trpn trpp 1 2 trpv 1 2 3 4 5 6 h 2 o solutes porin aquaporin 0 1 2 3 4 5 6 7 8 9 voltage dependent anion channel 1 2 3 general bacterial porin family cytoplasm gap junction connexin a gja1 gja3 gja4 gja5 gja8 gja9 gja10 b gjb1 gjb2 gjb3 gjb4 gjb5 gjb6 gjb7 c gjc1 gjc2 gjc3 d gjd2 gjd3 gjd4 innexin by gating mechanism ion channel class ligand gated light gated voltage gated stretch activated see also disorders v t e ion channel modulators calcium vdccs tooltip voltage dependent calcium channels blockers l type selective dihydropyridines amlodipine telmisartan and indapamide aranidipine azelnidipine barnidipine clevidipine cronidipine darodipine dexniguldipine elgodipine elnadipine felodipine flordipine furnidipine iganidipine isradipine lacidipine lemildipine lercanidipine levamlodipine levniguldipine manidipine mepirodipine mesudipine nicardipine nifedipine niguldipine niludipine nilvadipine nimodipine nisoldipine nitrendipine olradipine oxodipine palonidipine pranidipine ryodipine riodipine sagandipine sornidipine teludipine tiamdipine trombodipine vatanidipine diltiazem derivatives clentiazem diltiazem iprotiazem nictiazem siratiazem phenylalkylamines anipamil dagapamil devapamil dexverapamil emopamil etripamil falipamil gallopamil levemopamil nexopamil norverapamil ronipamil tiapamil verapamil others ah 1058 brinazarone budiodarone celivarone cyproheptadine dronedarone fantofarone sr 33805 tetrahydropalmatine n type selective ω conotoxins ω conotoxin gvia caroverine huwentoxin xvi leconotide ω conotoxin cvid pd 173212 ralfinamide safinamide z160 ziconotide ω conotoxin mviia p type selective ω agatoxin iva ω agatoxin ivb r type selective snx 482 t type selective abt 639 ml 218 niflumic acid nnc 55 0396 protx i z944 zonisamide non selective ω agatoxin tk ω conotoxin mviic benidipine bepridil cilnidipine cinnarizine dotarizine efonidipine flunarizine lamotrigine levetiracetam lomerizine loperamide mibefradil np078585 ruthenium red trox 1 α 2 δ subunit selective gabapentinoids 4 methylpregabalin arbaclofen arbaclofen placarbil atagabalin baclofen gabapentin gabapentin enacarbil imagabalin mirogabalin pd 200 347 pd 217 014 pd 299 685 phenibut pregabalin others unsorted bencyclane berbamine bevantolol canadine carboxyamidotriazole cycleanine dauricine dimeditiapramine diproteverine enpiperate eperisone elpetrigine ethadione ethanol alcohol ethosuximide fasudil fendiline fostedil imepitoin jtv 519 lidoflazine magnesium manoalide mesuximide monatepil naftopidil ochratoxin a osthol otilonium bromide paramethadione phensuximide pinaverium bromide prenylamine rhynchophylline sesamodil silperisone sipatrigine terodiline tetrandrine tolperisone trimethadione valperinol activators l type selective bay k8644 potassium vgkcs tooltip voltage gated potassium channels blockers 3 4 diaminopyridine amifampridine 4 aminopyridine fampridine dalfampridine adekalant almokalant amiodarone azimilide bretylium bunaftine charybdotoxin clamikalant conotoxins dalazatide dendrotoxin dofetilide dronedarone e 4031 hanatoxin hgetx1 hstx1 ibutilide inakalant kaliotoxin linopirdine lolitrem b maurotoxin nifekalant notoxin paxilline pinokalant quinidine shk 186 sotalol tedisamil terikalant tetraethylammonium vernakalant herg kcnh2 k v 11 1 specific ajmaline amiodarone ammtx3 astemizole azaspiracid azd1305 azimilide bedaquiline bekm 1 bmtx3 brl 32872 chlorpromazine cisapride clarithromycin darifenacin dextropropoxyphene diallyl trisulfide domperidone e 4031 ergtoxins erythromycin gigactonine haloperidol ketoconazole norpropoxyphene orphenadrine pimozide pnu 282 987 promethazine quinidine ranolazine roxithromycin sertindole solifenacin tamulotoxin terodiline terfenadine thioridazine tolterodine vanoxerine vernakalant kcnq k v 7 specific linopirdine spooky toxin sstx xe 991 activators kcnq k v 7 specific azetukalner encukalner cb03 154 fluoxakalner flupirtine opakalim pynegabine retigabine ezogabine irks tooltip inwardly rectifying potassium channel blockers k atp tooltip atp sensitive potassium channel specific acetohexamide carbutamide chlorpropamide glibenclamide glyburide glibornuride glicaramide gliclazide glimepiride glipizide gliquidone glisoxepide glyclopyramide glycyclamide metahexamide mitiglinide nateglinide repaglinide tolazamide tolbutamide girk tooltip g protein coupled inwardly rectifying potassium channel specific barium caramiphen cloperastine clozapine dextromethorphan ethosuximide ifenprodil tertiapin tipepidine activators k atp tooltip atp sensitive potassium channel specific aprikalim bimakalim cromakalim diazoxide emakalim levcromakalim mazokalim minoxidil minoxidil sulfate naminidil nicorandil pinacidil rilmakalim sarakalim girk tooltip g protein coupled inwardly rectifying potassium channel specific ml 297 vu0456810 k ca tooltip calcium activated potassium channel blockers bk ca specific ethanol alcohol gal 021 activators bk ca specific chlorzoxazone estradiol flindokalner flufenamic acid isopimaric acid meclofenamic acid niflumic acid nimesulide riluzole rottlerin mallotoxin tamoxifen tolfenamic acid vsn16r k2ps tooltip tandem pore domain potassium channel blockers 12 o tetradecanoylphorbol 13 acetate arachidonic acid fluoxetine norfluoxetine activators riluzole sodium vgscs tooltip voltage gated sodium channels blockers antianginals ranolazine antiarrhythmics class i ajmaline aprindine disopyramide dronedarone encainide flecainide lidocaine lorajmine lorcainide mexiletine moricizine pilsicainide prajmaline procainamide propafenone quinidine sparteine tocainide anticonvulsants acetylpheneturide carbamazepine cenobamate chlorphenacemide elpetrigine eslicarbazepine acetate ethotoin fosphenytoin lamotrigine lacosamide licarbazepine mephenytoin oxcarbazepine oxitriptyline phenacemide pheneturide phenytoin relutrigine rufinamide sipatrigine topiramate sodium valproate valnoctamide valproate pivoxil valproate semisodium valproic acid valpromide zonisamide local anesthetics p fbt amylocaine articaine benzocaine bupivacaine levobupivacaine ropivacaine butacaine butamben chloroprocaine cinchocaine cocaine cyclomethycaine dimethocaine diphenhydramine etidocaine hexylcaine iontocaine lidocaine mepivacaine meprylcaine metabutoxycaine orthocaine piperocaine prilocaine procaine propoxycaine proxymetacaine risocaine tetracaine trimecaine analgesics azd 3161 dsp 2230 funapide gdc 0276 nktr 171 pf 04531083 pf 05089771 ralfinamide raxatrigine rg7893 gdc 0287 suzetrigine toxins conotoxins neosaxitoxin saxitoxin tetrodotoxin zetekitoxin ab others buprenorphine evenamide menthol mint safinamide tricyclic antidepressants activators aconitine atracotoxins ω atracotoxin robustoxin versutoxin batrachotoxin ciguatoxins grayanotoxins poneratoxin enac tooltip epithelial sodium channel blockers amiloride benzamil triamterene activators solnatide asics tooltip acid sensing ion channel blockers a 317567 amiloride aspirin ibuprofen pctx1 chloride caccs tooltip calcium activated chloride channel blockers crofelemer dids ethacrynic acid flufenamic acid fluoxetine furosemide glibenclamide mefloquine mibefradil niflumic acid activators carbachol cftr tooltip cystic fibrosis transmembrane conductance regulator blockers glibenclamide lonidamine piretanide activators 1 7 phenanthroline 1 10 phenanthroline 4 7 phenanthroline 7 8 benzoquinoline ivacaftor phenanthridine unsorted blockers bumetanide flufenamic acid meclofenamic acid mefenamic acid mepacrine niflumic acid talniflumate tolfenamic acid trifluoperazine others trps tooltip transient receptor potential channels see here instead lgics tooltip ligand gated ion channels see here instead see also receptor signaling modulators transient receptor potential channel modulators this membrane protein related article is a stub you can help wikipedia by adding missing information v t e retrieved from https en wikipedia org w index php title two pore domain_potassium_channel oldid 1378328582 categories two pore domain channels membrane protein 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