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1998bbrc, 358t, 358, biochem, biophys, res, commun, iwasaki, bramlett, january, 11773444, 0755, 128, ser, 884, adjacent, trbp, defines, selectivity, ers, trs, 10823961, 18584, 2000pnas, 6212k, containing, anzick, choi, bubendorf, guan, kallioniemi, kononen, trent, azorsa, jhun, cheong, meltzer, 1999, 10567404, asc, amplified, essential, vivo, kim, february, 11158331, 0595, 241, distinct, signal, cointegrator, jeyakumar, tanen, bagchi, 9171239, 0003, 755, role, induced, liu, takeshita, misiti, lack, can, dominant, 204, 9751500, 6218, 4197, lin, zhao, august, 12048199, m203380200, 28733, cyclin, independent, repressor, monden, hollenberg, 9368056, coactivating, 54389426, 1973914, 90245, thra, alpha, grcm38, grch38, rxra, ppargc1a, nr2f6, ncor2, ncoa6, ncoa1, ccnd1, brd8, interact, activities, studies, mice, suggest, while, having, certain, extent, redundancy, defects, are, gthr, characterized, levels, circulating, normal, slightly, elevated, transcript, have, but, full, length, nature, 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receptors j biol chem 277 32 28733 41 doi 10 1074 jbc m203380200 pmid 12048199 1 2 liu y takeshita a misiti s chin ww yen pm october 1998 lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors endocrinology 139 10 4197 204 doi 10 1210 endo 139 10 6218 pmid 9751500 1 2 jeyakumar m tanen mr bagchi mk june 1997 analysis of the functional role of steroid receptor coactivator 1 in ligand induced transactivation by thyroid hormone receptor mol endocrinol 11 6 755 67 doi 10 1210 mend 11 6 0003 pmid 9171239 lee sk jung sy kim ys na sy lee yc lee jw february 2001 two distinct nuclear receptor interaction domains and creb binding protein dependent transactivation function of activating signal cointegrator 2 mol endocrinol 15 2 241 54 doi 10 1210 mend 15 2 0595 pmid 11158331 lee sk anzick sl choi je bubendorf l guan xy jung yk kallioniemi op kononen j trent jm azorsa d jhun bh cheong jh lee yc meltzer ps lee jw november 1999 a nuclear factor asc 2 as a cancer amplified transcriptional coactivator essential for ligand dependent transactivation by nuclear receptors in vivo j biol chem 274 48 34283 93 doi 10 1074 jbc 274 48 34283 pmid 10567404 ko l cardona gr chin ww may 2000 thyroid hormone receptor binding protein an lxxll motif containing protein functions as a general coactivator proc natl acad sci u s a 97 11 6212 7 bibcode 2000pnas 97 6212k doi 10 1073 pnas 97 11 6212 pmc 18584 pmid 10823961 ko l cardona gr iwasaki t bramlett ks burris tp chin ww january 2002 ser 884 adjacent to the lxxll motif of coactivator trbp defines selectivity for ers and trs mol endocrinol 16 1 128 40 doi 10 1210 mend 16 1 0755 pmid 11773444 tagami t lutz wh kumar r jameson jl december 1998 the interaction of the vitamin d receptor with nuclear receptor corepressors and coactivators biochem biophys res commun 253 2 358 63 bibcode 1998bbrc 253 358t doi 10 1006 bbrc 1998 9799 pmid 9878542 ando s sarlis nj krishnan j feng x refetoff s zhang mq oldfield eh yen pm september 2001 aberrant alternative splicing of thyroid hormone receptor in a tsh secreting pituitary tumor is a mechanism for hormone resistance mol endocrinol 15 9 1529 38 doi 10 1210 mend 15 9 0687 pmid 11518802 zhu xg park ks kaneshige m bhat mk zhu q mariash cn mcphie p cheng sy april 2000 the orphan nuclear receptor ear 2 is a negative coregulator for thyroid hormone nuclear receptor function mol cell biol 20 7 2604 18 doi 10 1128 mcb 20 7 2604 2618 2000 pmc 85476 pmid 10713182 wu y delerive p chin ww burris tp march 2002 requirement of helix 1 and the af 2 domain of the thyroid hormone receptor for coactivation by pgc 1 j biol chem 277 11 8898 905 doi 10 1074 jbc m110761200 pmid 11751919 further reading edit lazar ma chin ww 1990 nuclear thyroid hormone receptors j clin invest 86 6 1777 82 doi 10 1172 jci114906 pmc 329808 pmid 2254444 forrest d reh ta rüsch a 2002 neurodevelopmental control by thyroid hormone receptors curr opin neurobiol 12 1 49 56 doi 10 1016 s0959 4388 02 00289 1 pmid 11861164 s2cid 2884828 gonzález sancho jm garcía v bonilla f muñoz a 2003 thyroid hormone receptors thr genes in human cancer cancer lett 192 2 121 32 doi 10 1016 s0304 3835 02 00614 6 pmid 12668276 cugini cd leidy jw chertow bs bérard j bradley we menke jb hao eh usala sj 1992 an arginine to histidine mutation in codon 315 of the c erba beta thyroid hormone receptor in a kindred with generalized resistance to thyroid hormones results in a receptor with significant 3 5 3 triiodothyronine binding activity j clin endocrinol metab 74 5 1164 70 doi 10 1210 jcem 74 5 1314846 pmid 1314846 behr m loos u 1992 a point mutation ala229 to thr in the hinge domain of the c erba beta thyroid hormone receptor gene in a family with generalized thyroid hormone resistance mol endocrinol 6 7 1119 26 doi 10 1210 mend 6 7 1324420 pmid 1324420 falcone m miyamoto t fierro renoy f macchia e degroot lj 1992 antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform endocrinology 131 5 2419 29 doi 10 1210 endo 131 5 1425440 pmid 1425440 schmidt ed schmidt ed van der gaag r ganpat r broersma l de boer pa moorman af lamers wh wiersinga wm koornneef l 1992 distribution of the nuclear thyroid hormone receptor in extraocular and skeletal muscles j endocrinol 133 1 67 74 doi 10 1677 joe 0 1330067 pmid 1517709 adams m nagaya t tone y jameson jl chatterjee vk 1992 functional properties of a novel mutant thyroid hormone receptor in a family with generalized thyroid hormone resistance syndrome clin endocrinol 36 3 281 9 doi 10 1111 j 1365 2265 1992 tb01444 x pmid 1563081 s2cid 25897422 sasaki s nakamura h tagami t miyoshi y tanaka k imura h 1992 a point mutation of the t3 receptor beta 1 gene in a kindred of generalized resistance to thyroid hormone mol cell endocrinol 84 3 159 66 doi 10 1016 0303 7207 92 90026 3 pmid 1587388 s2cid 24853283 nagaya t madison ld jameson jl 1992 thyroid hormone receptor mutants that cause resistance to thyroid hormone evidence for receptor competition for dna sequences in target genes j biol chem 267 18 13014 9 doi 10 1016 s0021 9258 18 42375 7 pmid 1618799 shuto y wakabayashi i amuro n minami s okazaki t 1992 a point mutation in the 3 5 3 triiodothyronine binding domain of thyroid hormone receptor beta associated with a family with generalized resistance to thyroid hormone j clin endocrinol metab 75 1 213 7 doi 10 1210 jcem 75 1 1619012 pmid 1619012 näär am boutin jm lipkin sm yu vc holloway jm glass ck rosenfeld mg 1991 the orientation and spacing of core dna binding motifs dictate selective transcriptional responses to three nuclear receptors cell 65 7 1267 79 doi 10 1016 0092 8674 91 90021 p pmid 1648451 s2cid 22572347 usala sj menke jb watson tl wondisford fe weintraub bd bérard j bradley we ono s mueller ot bercu bb 1991 a homozygous deletion in the c erba beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance isolation and characterization of the mutant receptor mol endocrinol 5 3 327 35 doi 10 1210 mend 5 3 327 pmid 1653889 bodenner dl mroczynski ma weintraub bd radovick s wondisford fe 1991 a detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta subunit gene j biol chem 266 32 21666 73 doi 10 1016 s0021 9258 18 54688 3 pmid 1657975 parrilla r mixson aj mcpherson ja mcclaskey jh weintraub bd 1991 characterization of seven novel mutations of the c erba beta gene in unrelated kindreds with generalized thyroid hormone resistance evidence for two hot spot regions of the ligand binding domain j clin invest 88 6 2123 30 doi 10 1172 jci115542 pmc 295818 pmid 1661299 usala sj menke jb watson tl bérard we bradley c bale ae lash rw weintraub bd 1991 a new point mutation in the 3 5 3 triiodothyronine binding domain of the c erba beta thyroid hormone receptor is tightly linked to generalized thyroid hormone resistance j clin endocrinol metab 72 1 32 8 doi 10 1210 jcem 72 1 32 pmid 1846005 usala sj tennyson ge bale ae lash rw gesundheit n wondisford fe accili d hauser p weintraub bd 1990 a base mutation of the c erba beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance molecular heterogeneity in two other kindreds j clin invest 85 1 93 100 doi 10 1172 jci114438 pmc 296391 pmid 2153155 sakurai a takeda k ain k ceccarelli p nakai a seino s bell gi refetoff s degroot lj 1989 generalized resistance to thyroid hormone associated with a mutation in the ligand binding domain of the human thyroid hormone receptor beta proc natl acad sci u s a 86 22 8977 81 bibcode 1989pnas 86 8977s doi 10 1073 pnas 86 22 8977 pmc 298414 pmid 2510172 this article incorporates text from the united states national library of medicine which is in the public domain v t e pdb gallery 1bsx structure and specificity of nuclear receptor coactivator interactions 1n46 crystal structure of human tr beta ligand binding domain complexed with a potent subtype selective thyromimetic 1nax thyroid receptor beta1 in complex with a beta selective ligand 1nq0 tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd 1nq1 tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd 1nq2 two rth mutants with impaired hormone binding 1nuo two rth mutants with impaired hormone binding 1q4x crystal structure of human thyroid hormone receptor beta lbd in complex with specific agonist gc 24 1r6g crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound 1xzx thyroxine thyroid hormone receptor interactions 1y0x thyroxine thyroid hormone receptor interactions 2h6w 2nll retinoid x receptor thyroid hormone receptor dna binding domain heterodimer bound to thyroid response element dna v t e transcription factors and intracellular receptors 1 basic domains 1 1 basic leucine zipper bzip activating transcription factor aatf 1 2 3 4 5 6 7 ap 1 c fos fosb fosl1 fosl2 jdp2 c jun junb jund bach 1 2 batf blzf1 c ebp α β γ δ ε ζ creb 1 3 l1 crem dbp ddit3 gabpa gcn4 hlf maf b smaf f g k nfe 2 l1 l2 l3 nfil3 nrl nrf 1 2 3 xbp1 1 2 basic helix loop helix bhlh group a as c ascl1 ascl2 atoh1 hand 1 2 mesp2 myogenic regulatory factors myod myogenin myf5 myf6 neurod 1 2 neurogenins 1 2 3 olig 1 2 paraxis tcf15 scleraxis slc lyl1 tal 1 2 twist group b figla myc c myc l myc n myc mxd4 tcf4 group c bhlh pas ahr ahrr arnt arntl arntl2 clock hif 1a epas1 3a npas 1 2 3 per 1 2 3 period sim 1 2 group d dec 1 2 bhlha9 pho4 id 1 2 3 4 group e hes 1 2 3 4 5 6 7 hey 1 2 l group f bhlh coe ebf1 1 3 bhlh zip ap 4 max mxd1 mxd3 mitf mnt mlx mlxipl mxi1 myc srebp 1 2 usf1 1 4 nf 1 nfi a b c x smad r smad 1 2 3 5 9 i smad 6 7 4 1 5 rf x rfx 1 2 3 4 5 6 ank 1 6 basic helix span helix bhsh ap 2 α β γ δ ε 2 zinc finger dna binding domains 2 1 nuclear receptor cys 4 subfamily 1 thyroid hormone α β car fxr ecr lxr α β ppar α β δ γ pxr rar α β γ ror α β γ rev erba α β vdr subfamily 2 coup tf i ii ear 2 hnf4 α γ pnr rxr α β γ testicular receptor 2 4 tlx subfamily 3 steroid hormone androgen estrogen α β glucocorticoid mineralocorticoid progesterone estrogen related α β γ subfamily 4 nur ngfib nor1 nurr1 subfamily 5 lrh 1 sf1 subfamily 6 gcnf subfamily 0 dax1 shp 2 2 other cys 4 gata 1 2 3 4 5 6 mta 1 2 3 trps1 2 3 cys 2 his 2 general transcription factors tfiia tfiib tfiid tfiie 1 2 tfiif 1 2 tfiih 1 2 4 2i 3a 3c1 3c2 atbf1 bcl 6 11a 11b ctcf e4f1 egr 1 2 3 4 erv3 gfi1 gli family 1 2 3 rest s1 s2 yy1 hic 1 2 hivep 1 2 3 ikzf 1 2 3 ilf 2 3 sp klf family klf 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 17 sp 1 2 4 7 8 mtf1 myt1 osr1 prdm9 sall 1 2 3 4 tshz3 wt1 zbtb7 7a 7b zbtb 11 14 16 17 18 20 21 32 33 40 zinc finger 3 7 9 10 19 22 24 33b 34 35 41 43 44 51 74 143 146 148 165 202 217 219 239 259 267 268 281 300 318 330 346 350 365 366 384 423 451 452 471 593 638 644 649 655 804a 2 4 cys 6 hivep1 2 5 alternating composition aire dido1 grlf1 ing 1 2 4 jarid 1a 1b 1c 1d 2 jmjd1b 2 6 wrky wrky 3 helix turn helix domains 3 1 homeodomain antennapedia antp class protohox hox like parahox gsx 1 2 xlox pdx1 cdx 1 2 4 extended hox evx1 evx2 meox1 meox2 homeobox a1 a2 a3 a4 a5 a7 a9 a10 a11 a13 b1 b2 b3 b4 b5 b6 b7 b8 b9 b13 c4 c5 c6 c8 c9 c10 c11 c12 c13 d1 d3 d4 d8 d9 d10 d11 d12 d13 gbx1 gbx2 mnx1 metahox nk like barhl1 barhl2 barx1 barx2 bsx dbx 1 2 dlx 1 2 3 4 5 6 emx 1 2 en 1 2 hhex hlx lbx1 lbx2 msx 1 2 nanog nkx 2 1 2 2 2 3 2 5 2 9 3 1 3 2 hmx1 hmx2 hmx3 6 1 6 2 noto tlx1 tlx2 tlx3 vax1 vax2 other arx crx cutl1 fhl 1 2 3 hesx1 hopx jade 1 2 3 lmx 1a 1b nobox tale irx 1 2 3 4 5 6 mkx meis 1 2 pbx 1 2 3 pknox 1 2 six 1 2 3 4 5 phf 1 3 6 8 10 20 21a pou domain pit 1 brn 3 a b c octamer transcription factor 1 2 3 4 6 7 11 satb2 zeb 1 2 3 2 paired box pax 1 2 3 4 5 6 7 8 9 prrx 1 2 prop1 phox 2a 2b rax shox shox2 vsx1 vsx2 bicoid gsc bicd2 otx 1 2 pitx 1 2 3 3 3 fork head winged helix e2f 1 2 3 4 5 fox proteins a1 a2 a3 b1 b2 c1 c2 d1 d2 d3 d4 d4l1 d4l3 d4l4 d4l5 d4l6 e1 e3 f1 f2 g1 h1 i1 i2 i3 j1 j2 j3 k1 k2 l1 l2 m1 n1 n2 n3 n4 o1 o3 o4 o6 p1 p2 p3 p4 q1 r1 r2 s1 3 4 heat shock factors hsf 1 2 4 3 5 tryptophan clusters elf 2 4 5 ehf elk 1 3 4 erf ets 1 2 erg spib etv 1 4 5 6 fli1 interferon regulatory factors 1 2 3 4 5 6 7 8 myb mybl2 3 6 tea domain transcriptional enhancer factor 1 2 3 4 4 β scaffold factors with minor groove contacts 4 1 rel homology region nf κb nfkb1 nfkb2 rel rela relb nfat c1 c2 c3 c4 5 4 2 stat stat 1 2 3 4 5 6 4 3 p53 like p53 p63 p73 family p53 tp63 p73 tbx 1 2 3 5 19 21 22 tbr1 tbr2 tft myrf 4 4 mads box mef2 a b c d srf 4 6 tata binding proteins tbp tbpl1 4 7 high mobility group bbx hmgb 1 2 3 4 hmgn 1 2 3 4 hnf 1a 1b sox 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 sry ssrp1 tcf lef tcf 1 3 4 lef1 tox 1 2 3 4 4 9 grainyhead tfcp2 4 10 cold shock domain ybx1 ybx2 ybx3 4 11 runt cbf cbfa2t2 cbfa2t3 runx1 runx2 runx3 runx1t1 0 other transcription factors 0 2 hmgi y hmga 1 2 hbp1 0 3 pocket domain rb rbl1 rbl2 0 5 ap 2 erebp related factors apetala 2 erebp b3 0 6 miscellaneous arid 1a 1b 2 3a 3b 4a cap ifi 16 35 mll 2 3 t1 mnda nfy a b c rho sigma see also transcription factor coregulator deficiencies v t e thyroid hormone receptor modulators receptor ligands thr tooltip thyroid hormone receptor agonists dextrothyroxine dimit ditpa levothyroxine liothyronine liotrix thyroxine tiratricol triac triiodothyronine thyroid extract thyromimetics selective agonists elunetirom abx 002 ma jd21 eprotirome kb 2115 kb 141 kb 2611 kb 130015 mb 07344 mb 07811 resmetirom sobetirome gc 1 grx 431 vk 0214 vk 2809 zyt1 antagonists 1 850 nh3 tetraiodothyroacetic acid tetrac transporter blockers nis tooltip sodium iodide cotransporter inhibitors cyanogenic glycosides perchlorates e g potassium perchlorate pertechnetates e g sodium pertechnetate thiocyanates enzyme inhibitors tpo tooltip thyroid peroxidase inhibitors benzylthiouracil carbimazole genistein methimazole methylthiouracil propylthiouracil 2 thiouracil thiourea dio tooltip iodothyronine deiodinase inhibitors dexpropranolol iopanoic acid ipodate sodium sodium iopodate propranolol propylthiouracil others iodine iodine 131 selenium thyroglobulin tyrosine see also receptor signaling modulators retrieved from https en wikipedia org w index php title thyroid_hormone_receptor_beta oldid 1378900813 categories genes on human chromosome 3 intracellular receptors transcription factors thyroid hormone receptors hidden categories articles with short description short description matches wikidata wikipedia articles incorporating text from the united states national library of medicine this page was last edited on 6 october 2026 at 20 34 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the 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