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urokinase receptor wikipedia jump to content main menu main menu move to sidebar hide navigation main page contents current events random article about wikipedia contact us contribute help learn to edit community portal recent changes upload file special pages search search appearance donate create account log in personal tools donate create account log in contents move to sidebar hide top 1 structure 2 function 3 clinical significance 4 interactions 5 see also 6 references 7 further reading 8 external links toggle the table of contents urokinase receptor 7 languages cymraeg deutsch 日本語 русский татарча tatarça українська 中文 edit links article talk english read edit view history tools tools move to sidebar hide actions read edit view history general what links here related changes upload file permanent link page information cite this page get shortened url switch to legacy parser print export download as pdf printable version in other projects wikimedia commons wikidata item appearance move to sidebar hide from wikipedia the free encyclopedia mammalian protein found in homo sapiens plaur identifiers aliases plaur cd87 u par upar urkr plasminogen activator urokinase receptor external ids omim 173391 mgi 97612 genecards plaur available structures pdb ortholog search pdbe rcsb list of pdb id codes 1ywh 2fd6 3bt1 3bt2 3u73 3u74 2i9b 4k24 4qti gene location human chr chromosome 19 human 1 band 19q13 31 start 43 646 095 bp 1 end 43 670 547 bp 1 gene location mouse chr chromosome 7 mouse 2 band 7 7 a3 start 24 161 909 bp 2 end 24 175 393 bp 2 rna expression pattern bgee human mouse ortholog top expressed in periodontal fiber monocyte stromal cell of endometrium vena cava gallbladder blood bone marrow cell cartilage tissue granulocyte right lung top expressed in granulocyte decidua endothelial cell of lymphatic vessel tibiofemoral joint right lung lobe bone marrow calvaria stroma of bone marrow mucous cell of stomach spleen more reference expression data biogps more reference expression data gene ontology molecular function protein domain specific binding protein binding urokinase plasminogen activator receptor activity enzyme binding signaling receptor binding signaling receptor activity cellular component integral component of membrane cell projection endoplasmic reticulum lumen endoplasmic reticulum membrane membrane focal adhesion integral component of plasma membrane extracellular region cell junction anchored component of membrane extracellular exosome extrinsic component of membrane plasma membrane specific granule membrane cell surface biological process positive regulation of protein phosphorylation negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway fibrinolysis negative regulation of intrinsic apoptotic signaling pathway urokinase plasminogen activator signaling pathway negative regulation of apoptotic process blood coagulation attachment of gpi anchor to protein chemotaxis positive regulation of release of cytochrome c from mitochondria positive regulation of dna binding positive regulation of epidermal growth factor receptor signaling pathway regulation of proteolysis signal transduction neutrophil degranulation sources amigo quickgo orthologs databases ncbi entry oma entry species human mouse entrez 5329 18793 ensembl ensg00000011422 ensmusg00000046223 uniprot q03405 p35456 refseq mrna nm_001005376 nm_001005377 nm_001301037 nm_002659 nm_011113 refseq protein np_001005376 np_001005377 np_001287966 np_002650 np_035243 location ucsc chr 19 43 65 43 67 mb chr 7 24 16 24 18 mb pubmed search 3 4 wikidata view edit human view edit mouse the urokinase receptor also known as urokinase plasminogen activator surface receptor upar or cd87 c luster of d ifferentiation 87 is a protein encoded in humans by the plaur gene it is a multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol gpi anchor upar was originally identified as a saturable binding site for urokinase also known as upa on the cell surface structure edit upar consists of three tandem lu domains which are protein domains of the three finger protein family 5 the structure of upar has been solved by x ray crystallography in complex with a peptide antagonist 6 and with its native ligand urokinase 7 all three three finger domains are necessary for high affinity binding of the primary ligand urokinase in addition upar also interacts with several other proteins including vitronectin the upar associated protein uparap and the integrin family of membrane proteins it has been possible to express upar recombinantly in cho cells and s2 cells from drosophila melanogaster 4 out of 5 of the possible glycosylation sites are used in vivo giving the protein a molecular weight of 50 60 kda function edit upar is a part of the plasminogen activation system which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing in order to be able to reorganize tissue the old tissue must be able to be degraded an important mechanism in this degradation is the proteolysis cascade initiated by the plasminogen activation system upar binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane when urokinase is bound to the receptor there is cleavage between the gpi anchor and the upar releasing a soluble form of the protein known as supar 8 9 clinical significance edit soluble urokinase plasminogen activator receptor supar has been found to be a biomarker of inflammation 10 elevated supar is seen in chronic obstructive pulmonary disease asthma liver failure heart failure cardiovascular disease and rheumatoid arthritis 10 smokers have significantly higher supar compared to non smokers 10 urokinase receptors have been found to be highly expressed on senescent cells leading researchers to use chimeric antigen receptor t cells to eliminate senescent cells in mice 11 12 the components of the plasminogen activation system have been found to be highly expressed in many malignant tumors indicating that tumors are able to hijack the system and use it in metastasis thus inhibitors of the various components of the plasminogen activation system have been sought as possible anticancer drugs 13 upar has been involved in various other non proteolytic processes related to cancer such as cell migration cell cycle regulation and cell adhesion interactions edit urokinase receptor has been shown to interact with lrp1 14 see also edit cancer cluster of differentiation metastasis plasmin supar urokinase references edit 1 2 3 grch38 ensembl release 89 ensg00000011422 ensembl may 2017 1 2 3 grcm38 ensembl release 89 ensmusg00000046223 ensembl may 2017 human pubmed reference national center for biotechnology information u s national library of medicine mouse pubmed reference national center for biotechnology information u s national library of medicine kessler p marchot p silva m servent d august 2017 the three finger toxin fold a multifunctional structural scaffold able to modulate cholinergic functions journal of neurochemistry 142 suppl 2 7 18 doi 10 1111 jnc 13975 pmid 28326549 llinas p le du mh gårdsvoll h danø k ploug m gilquin b et al may 2005 crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide the embo journal 24 9 1655 1663 doi 10 1038 sj emboj 7600635 pmc 1142576 pmid 15861141 huai q mazar ap kuo a parry gc shaw de callahan j et al february 2006 structure of human urokinase plasminogen activator in complex with its receptor science 311 5761 656 659 bibcode 2006sci 311 656h doi 10 1126 science 1121143 pmid 16456079 s2cid 39521660 what is supar suparnostic by virogates retrieved 2021 09 27 thunø m macho b eugen olsen j 2009 supar the molecular crystal ball disease markers 27 3 157 172 doi 10 1155 2009 504294 pmc 3835059 pmid 19893210 1 2 3 desmedt s desmedt v delanghe jr speeckaert r speeckaert mm march 2017 the intriguing role of soluble urokinase receptor in inflammatory diseases critical reviews in clinical laboratory sciences 54 2 117 133 doi 10 1080 10408363 2016 1269310 pmid 28084848 s2cid 32624995 wagner v gil j july 2020 t cells engineered to target senescence nature 583 7814 37 38 bibcode 2020natur 583 37w doi 10 1038 d41586 020 01759 x hdl 10044 1 80980 pmid 32601490 amor c feucht j leibold j ho yj zhu c alonso curbelo d et al july 2020 senolytic car t cells reverse senescence associated pathologies nature 583 7814 127 132 bibcode 2020natur 583 127a doi 10 1038 s41586 020 2403 9 pmc 7583560 pmid 32555459 madunić j december 2018 the urokinase plasminogen activator system in human cancers an overview of its prognostic and predictive role thrombosis and haemostasis 118 12 2020 2036 doi 10 1055 s 0038 1675399 pmid 30419600 czekay rp kuemmel ta orlando ra farquhar mg may 2001 direct binding of occupied urokinase receptor upar to ldl receptor related protein is required for endocytosis of upar and regulation of cell surface urokinase activity molecular biology of the cell 12 5 1467 1479 doi 10 1091 mbc 12 5 1467 pmc 34598 pmid 11359936 further reading edit ploug m 2003 structure function relationships in the interaction between the urokinase type plasminogen activator and its receptor current pharmaceutical design 9 19 1499 1528 doi 10 2174 1381612033454630 pmid 12871065 kjøller l january 2002 the urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motility biological chemistry 383 1 5 19 doi 10 1515 bc 2002 002 pmid 11928822 s2cid 6125978 chavakis t kanse sm may ae preissner kt april 2002 haemostatic factors occupy new territory the role of the urokinase receptor system and kininogen in inflammation biochemical society transactions 30 2 168 173 doi 10 1042 bst0300168 pmid 12023845 ploug m gårdsvoll h jørgensen tj lønborg hansen l danø k april 2002 structural analysis of the interaction between urokinase type plasminogen activator and its receptor a potential target for anti invasive cancer therapy biochemical society transactions 30 2 177 183 doi 10 1042 bst0300177 pmid 12023847 alfano m sidenius n blasi f poli g november 2003 the role of urokinase type plasminogen activator upa upa receptor in hiv 1 infection journal of leukocyte biology 74 5 750 756 doi 10 1189 jlb 0403176 pmid 12960238 s2cid 8526093 alfano d franco p vocca i gambi n pisa v mancini a et al february 2005 the urokinase plasminogen activator and its receptor role in cell growth and apoptosis thrombosis and haemostasis 93 2 205 211 doi 10 1160 th04 09 0592 pmid 15711734 s2cid 35517406 external links edit plaur protein human at the u s national library of medicine medical subject headings mesh overview of all the structural information available in the pdb for uniprot q03405 human urokinase plasminogen activator surface receptor at the pdbe kb v t e pdb gallery 1ywh crystal structure of urokinase plasminogen activator receptor 2fd6 structure of human urokinase plasminogen activator in complex with urokinase receptor and an anti upar antibody at 1 9 a 2i9b crystal structure of atf urokinase receptor complex v t e proteins clusters of differentiation see also list of human clusters of differentiation 1 50 1 a c 1a 1b 1d 1e 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 a b 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 a b 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50 51 100 51 52 53 54 55 56 57 58 59 61 62 e l p 63 64 a b c 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 150 101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150 151 200 151 152 153 154 155 156 a b c 157 158 a d e i k 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200 201 250 201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 a b 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240ce 240d 241 243 244 246 247 248 249 251 300 252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299 301 350 300a 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350 351 371 351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371 category commons retrieved from https en wikipedia org w index php title urokinase_receptor oldid 1283090849 categories genes on human chromosome 19 clusters of differentiation hidden categories articles with short description short description matches wikidata cs1 long volume value this page was last edited on 30 march 2025 at 11 26 utc page was rendered with parsoid text is available under the creative commons attribution sharealike 4 0 license additional terms may apply by using this site you agree to the terms of use and privacy policy wikipedia is a registered trademark of the wikimedia foundation inc a non profit organization privacy policy about wikipedia disclaimers contact wikipedia legal safety contacts code of conduct developers statistics cookie statement mobile view search search toggle the table of contents urokinase receptor 7 languages add topic