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hypnotics sedatives n05c gaba a alcohols 2m2b chloralodol ethanol alcohol diethylpropanediol ethchlorvynol methylpentynol trichloroethanol barbiturates allobarbital amobarbital aprobarbital barbital butabarbital butobarbital cyclobarbital ethallobarbital heptabarb hexobarbital mephobarbital methohexital narcobarbital pentobarbital phenallymal phenobarbital propylbarbital proxibarbal reposal secobarbital talbutal thiamylal thiopental thiotetrabarbital vinbarbital vinylbital benzodiazepines brotizolam cinolazepam climazolam clobazam clonazolam doxefazepam estazolam flubromazolam flunitrazolam flunitrazepam flurazepam flutemazepam flutoprazepam loprazolam lormetazepam midazolam nimetazepam nitemazepam nitrazepam nitrazolam quazepam temazepam triazolam carbamates carisoprodol emylcamate ethinamate hexapropymate meprobamate methocarbamol phenprobamate procymate tybamate imidazoles etomidate metomidate propoxate monoureides acecarbromal apronal apronalide bromisoval capuride carbromal ectylurea neurosteroids acebrochol alfadolone alfaxolone brexanolone allopregnanolone eltanolone pregnanolone ganaxolone hydroxydione minaxolone progesterone renanolone zuranolone nonbenzodiazepines eszopiclone indiplon lirequinil necopidem pagoclone pazinaclone saripidem suproclone suriclone zaleplon zolpidem zopiclone phenols cipepofol ciprofol fospropofol propofol propofol hemisuccinate piperidinediones glutethimide methyprylon piperidione pyrithyldione quinazolinones afloqualone cloroqualone diproqualone etaqualone mebroqualone mecloqualone methaqualone methylmethaqualone nitromethaqualone sl 164 others acetophenone acetylglycinamide chloral hydrate bromide compounds lithium bromide potassium bromide sodium bromide centalun chloral betaine chloral hydrate chloralose clomethiazole dichloralphenazone gaboxadol thip ibotenic acid amanita muscaria kavalactones loreclezole muscimol amanita muscaria paraldehyde petrichloral sesquiterpene isovaleramide isovaleric acid valerenic acid sulfonylalkanes sulfonmethane sulfonal tetronal trional triclofos gaba b 1 4 butanediol 4 fluorophenibut aceburic acid baclofen gabob ghb sodium oxybate gbl gvl jzp 386 phenibut tolibut valiloxybate xw 10172 h 1 antihistamines captodiame cyproheptadine diphenhydramine doxylamine hydroxyzine methapyrilene perlapine pheniramine promethazine propiomazine antidepressants serotonin antagonists and reuptake inhibitors etoperidone nefazodone trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc α 2 adrenergic clonidine detomidine dexmedetomidine lofexidine medetomidine romifidine tasipimidine tizanidine xylazine 5 ht 2a antidepressants trazodone tricyclic antidepressants amitriptyline doxepin trimipramine etc tetracyclic antidepressants mianserin mirtazapine etc antipsychotics typical antipsychotics chlorpromazine thioridazine etc atypical antipsychotics olanzapine quetiapine risperidone etc others niaprazine melatonin agomelatine melatonin ramelteon tasimelteon orexin daridorexant lemborexant suvorexant α 2 δ vdcc atagabalin baclofen gabapentin gabapentin enacarbil mirogabalin phenibut pregabalin others cannabinoids e g cannabis tetrahydrocannabinol dronabinol nabilone cannabidiol zenivol chlorophenylalkyldiols fenpentadiol metaglycodol phenaglycodol diethylpropanediol metamizil evoxine fenadiazole gaba reuptake inhibitors e g tiagabine guaifenesin related muscle relaxants chlorphenesin mephenesin mephenoxalone metaxalone methocarbamol midaflur opioids e g morphine passion flower pellotine phemerazole scopolamine serotonin precursors e g tryptophan 5 hydroxytryptophan 5 htp oxitriptan trazodone tributyrin umb68 valnoctamide v t e insomnia medications gaba a receptor positive modulators benzodiazepines brotizolam cinolazepam climazolam clorazepate doxefazepam estazolam etizolam flunitrazepam flurazepam flutoprazepam haloxazolam loprazolam lormetazepam midazolam nimetazepam nitrazepam quazepam temazepam triazolam nonbenzodiazepines z drugs eszopiclone zaleplon zolpidem zopiclone others alcohols e g ethchlorvynol amylene hydrate ethanol barbiturates e g amobarbital pentobarbital phenobarbital secobarbital bromides e g potassium bromide sodium bromide carbamates e g meprobamate chloral hydrate clomethiazole kava neurosteroids e g progesterone zuranolone paraldehyde piperidinediones e g glutethimide quinazolinones e g methaqualone sulfonmethane valerian antihistamines h 1 receptor inverse agonists alimemazine captodiame cyproheptadine dimenhydrinate diphenhydramine doxylamine etodroxizine hydroxyzine meclizine methapyrilene pheniramine phenyltoloxamine pimethixene promethazine propiomazine pyrilamine tricyclic antidepressants e g amitriptyline doxepin trimipramine tetracyclic antidepressants e g mirtazapine triprolidine orexin receptor antagonists daridorexant fazamorexant lemborexant seltorexant suvorexant vornorexant melatonin receptor agonists melatonin ramelteon tasimelteon others α 1 adrenergic receptor antagonists e g prazosin α 2 adrenergic receptor agonists e g clonidine tizanidine antipsychotics e g quetiapine olanzapine risperidone chlorpromazine ashwagandha benzoctamine cannabinoids e g cannabis dronabinol thc nabilone zenivol chamomile fenadiazole gaba a receptor agonists e g gaboxadol thip muscimol amanita muscaria gaba b receptor agonists e g sodium oxybate γ hydroxybutyrate ghb baclofen phenibut gaba reuptake inhibitors e g tiagabine gabapentinoids e g gabapentin gabapentin enacarbil pregabalin hops lavender menthyl isovalerate opioids e g hydrocodone oxycodone morphine passion flower pellotine scopolamine serotonin precursors tryptophan 5 hydroxytryptophan 5 htp oxitriptan phenylpiperazines e g trazodone niaprazine theanine tributyrin tricyclic antidepressants e g amitriptyline doxepin trimipramine tetracyclic antidepressants e g mirtazapine valnoctamide who em withdrawn from market clinical trials phase iii never to phase iii v t e anxiolytics n05b 5 ht 1a r tooltip 5 ht1a receptor agonists buspirone gepirone tandospirone gaba a r tooltip gabaa receptor pams tooltip positive allosteric modulators benzodiazepines adinazolam alprazolam bromazepam camazepam chlordiazepoxide clobazam clonazepam clorazepate clotiazepam cloxazolam diazepam ethyl loflazepate etizolam fludiazepam halazepam ketazolam lorazepam medazepam nordazepam oxazepam pinazepam prazepam others alpidem barbiturates e g phenobarbital carbamates e g meprobamate carisoprodol chlormezanone ethanol alcohol etifoxine gabapentinoids α 2 δ vdcc blockers gabapentin gabapentin enacarbil phenibut baclofen pregabalin antidepressants ssris tooltip selective serotonin reuptake inhibitors e g escitalopram snris tooltip serotonin norepinephrine reuptake inhibitors e g duloxetine saris tooltip serotonin antagonist and reuptake inhibitors e g trazodone tcas tooltip tricyclic antidepressants...