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and (95), hiv (54), the (51), with (43), cell (25), associated (24), #immune (22), pdf (20), text (20), art (20), cells (20), reservoir (19), cd4 (19), that (15), viral (15), these (14), pwh (13), #activation (13), fibrosis (13), mtb (13), siv (13), for (12), authors (12), people (12), monocyte (11), sat (11), infection (11), this (10), are (10), abstract (10), view (10), was (10), jennifer (9), reservoirs (9), distinct (9), david (9), plasma (9), levels (9), expression (9), during (9), granulomas (9), risk (8), inflammation (8), cd8 (8), estrogen (8), derived (8), mdscs (8), control (8), neurocognitive (8), despite (7), antiretroviral (7), therapy (7), metabolic (7), mechanisms (7), latency (7), treated (7), findings (7), ecd4 (7), were (6), katherine (6), intact (6), systemic (6), peter (6), hunt (6), transcriptional (6), from (6), elevated (6), early (6), anthony (6), receptor (6), reversal (6), erα (6), not (6), ana (6), adrian (6), maria (6), increased (6), sarah (6), jeffrey (6), 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Text of the page (random words):
el j buffa hafsa rana zoï vahlas joaquina barros mariano maio thomas r o neil kirstie m bertram eunok lee najla nasr andrew n harman gabriela turk maria florencia quiroga anthony d kelleher christel vérollet luciana balboa sarah palmer gabriel duette samantha cronin jennifer simpson andrea pereyra casanova yuchen li josefina marín rojas freja a warner van dijk katie fisher daniel j buffa hafsa rana zoï vahlas joaquina barros mariano maio thomas r o neil kirstie m bertram eunok lee najla nasr andrew n harman gabriela turk maria florencia quiroga anthony d kelleher christel vérollet luciana balboa sarah palmer gabriel duette view text pdf the pleural tuberculosis associated microenvironment promotes hiv 1 persistence by impairing cd8 t cell mediated viral control text pdf abstract mycobacteriumtuberculosis mtb the causative agent of tuberculosis tb is the most common coinfection in people living with hiv 1 plwh this coinfection is associated with accelerated hiv 1 disease progression and reduced survival however the immunological and virological mechanisms driving this progression are not completely understood to address this knowledge gap using pleural effusion samples from plwh and tb we investigated how the hiv 1 genetic landscape and the anti hiv 1 immune response are impacted by a tb associated microenvironment our results revealed an enrichment of genetically intact hiv 1 and impaired cd8 t cell mediated antiviral response at this site of hiv 1 mtb coinfection moreover efficient cd8 t cell activation was inhibited by lipids present in the tb associated pleural effusion these findings indicate that this immune microenvironment induced by tb promotes the persistence of cells infected with replication competent hiv 1 by creating a niche of reduced antiviral immune pressure potentially contributing to the worsened clinical outcomes observed in plwh and tb authors samantha cronin jennifer simpson andrea pereyra casanova yuchen li josefina marín rojas freja a warner van dijk katie fisher daniel j buffa hafsa rana zoï vahlas joaquina barros mariano maio thomas r o neil kirstie m bertram eunok lee najla nasr andrew n harman gabriela turk maria florencia quiroga anthony d kelleher christel vérollet luciana balboa sarah palmer gabriel duette multi omics links microbial dysbiosis systemic inflammation and metabolomic disruptions to snae risk in treated hiv christopher m basting jodi anderson kevin escandón garritt wieking candace guerrero jarrett reichel ross t cromarty erik swanson ty schroeder elaina creagan maura barrett fernanda torres ruiz maribel soto nava lady carvajal ruiz karla krystel ordaz candelario olivia briceño nicholas funderburg melanie graham peter hunt santiago avila rios gonzalo salgado montes de oca timothy w schacker nichole r klatt christopher m basting jodi anderson kevin escandón garritt wieking candace guerrero jarrett reichel ross t cromarty erik swanson ty schroeder elaina creagan maura barrett fernanda torres ruiz maribel soto nava lady carvajal ruiz karla krystel ordaz candelario olivia briceño nicholas funderburg melanie graham peter hunt santiago avila rios gonzalo salgado montes de oca timothy w schacker nichole r klatt view text pdf multi omics links microbial dysbiosis systemic inflammation and metabolomic disruptions to snae risk in treated hiv text pdf abstract serious non aids events snaes including non aids malignancies cardiovascular disease and hepatic complications remain major causes of mortality in treated hiv infection these outcomes are driven by persistent immune activation systemic inflammation and metabolic dysfunction despite effective viral suppression with antiretroviral therapy art to investigate mechanisms underlying snae pathogenesis we performed a cross site multi omic analysis integrating plasma proteins plasma metabolites and mucosal microbiomes in 82 art treated people with hiv pwh and 10 people without hiv from the united states and mexico geography was the dominant source of variation particularly across lipid classes however individuals at high risk for snaes defined by low cd4 t cell counts and low cd4 cd8 ratios shared a consistent signature of systemic inflammation mitochondrial dysfunction and microbial dysbiosis including elevated plasma il 6 and ω oxidation products adipic and suberic acids and depletion of short chain fatty acid producing commensals in the gut mucosa including akkermansia muciniphila bacteroides uniformis and ruminococcus a muciniphila abundance correlated with lower il 6 levels fewer hiv rna producing cells in lymph nodes and higher cd4 cd8 ratios these findings identify a shared inflammatory and metabolic phenotype in pwh and implicate a muciniphila as a potential microbiome based target to mitigate immune activation and snae risk in treated hiv authors christopher m basting jodi anderson kevin escandón garritt wieking candace guerrero jarrett reichel ross t cromarty erik swanson ty schroeder elaina creagan maura barrett fernanda torres ruiz maribel soto nava lady carvajal ruiz karla krystel ordaz candelario olivia briceño nicholas funderburg melanie graham peter hunt santiago avila rios gonzalo salgado montes de oca timothy w schacker nichole r klatt microbiome derived metabolites shape cd4 t cell differentiation and immune aging in hiv 1 infection amanda cabral da silva luke flantzer jaclyn weinberg shuya kyu lisa p daley bauer anyce godoy ana carolina santana aarthi talla amber rittgers sarah welbourn david e gordon jeffrey a tomalka vincent c marconi dean p jones souheil antoine younes amanda cabral da silva luke flantzer jaclyn weinberg shuya kyu lisa p daley bauer anyce godoy ana carolina santana aarthi talla amber rittgers sarah welbourn david e gordon jeffrey a tomalka vincent c marconi dean p jones souheil antoine younes view text pdf microbiome derived metabolites shape cd4 t cell differentiation and immune aging in hiv 1 infection text pdf abstract the role of aromatic gut derived bacterial metabolites gdbms in shaping immune cell metabolism and function remains poorly explored using ex vivo metabolomic profiling of paired plasma and cd4 t cells from people living with hiv 1 plwh we identified a network of aromatic gdbms whose cell associated abundance rather than systemic levels was linked to broad alterations in cd4 t cell metabolic and functional states among these p cresol sulfate pcs emerged as a mechanistic prototype ex vivo flow cytometry and single cell rna sequencing of cd4 t cells stratified by cell associated pcs levels revealed dose dependent enrichment of transcriptional programs associated with impaired differentiation regulatory like identity and cellular senescence in vitro transcriptomic and proteomic analyses of pcs exposed cd4 t cells demonstrated induction of cell cycle arrest mitochondrial dysfunction and senescence associated programs including upregulation of p16 and p21 integration of these immunometabolic findings with hiv 1 reservoir measurements revealed that cd4 t cell states defined by cell associated gdbms track with intact proviral dna levels in vivo these findings define a microbiome derived axis that reshapes cd4 t cell metabolism and fate promotes immune aging in plwh and may foster immunometabolic states linked to long term hiv 1 reservoir persistence authors amanda cabral da silva luke flantzer jaclyn weinberg shuya kyu lisa p daley bauer anyce godoy ana carolina santana aarthi talla amber rittgers sarah welbourn david e gordon jeffrey a tomalka vincent c marconi dean p jones souheil antoine younes granulocytic myeloid derived suppressor cells sustain hiv reservoirs by inhibiting viral reactivation via arginase 1 mediated mechanisms ana gallego cortés judith grau expósito irene mota gómez aleix benitez martinez josep castellvi jordi navarro adrian curran joaquin burgos paula suanzes vicenç falcó meritxell genescà maria j buzon ana gallego cortés judith grau expósito irene mota gómez aleix benitez martinez josep castellvi jordi navarro adrian curran joaquin burgos paula suanzes vicenç falcó meritxell genescà maria j buzon view text pdf granulocytic myeloid derived suppressor cells sustain hiv reservoirs by inhibiting viral reactivation via arginase 1 mediated mechanisms text pdf abstract myeloid derived suppressor cells mdscs represent a heterogeneous population of immature myeloid cells with potent immunosuppressive capabilities that contribute to viral persistence in chronic infections however their direct impact on the latent hiv reservoir remains poorly understood here we report that people with hiv pwh exhibit elevated levels of mdscs with notable immunosuppressive activity both granulocytic g mdscs and monocytic m mdscs subsets expressing arginase 1 arg1 or indoleamine 2 3 dioxygenase ido are increased during treated infection with low level viral transcription preferentially associated with the expansion of highly suppressive g mdscs functional assays revealed that g mdscs robustly inhibit hiv reactivation from latent reservoirs mechanistically g mdscs mediate this inhibition through a contact independent mechanism primarily involving arg1 activity our findings demonstrate the capacity of g mdscs to sustain hiv reservoirs suggesting that targeting these cells could potentiate therapeutic strategies aimed at eliminating hiv reservoirs through viral reactivation authors ana gallego cortés judith grau expósito irene mota gómez aleix benitez martinez josep castellvi jordi navarro adrian curran joaquin burgos paula suanzes vicenç falcó meritxell genescà maria j buzon impact of specific ligands and hiv latency reversal agents on estrogen receptor alpha in cd4 t cells cristina ceriani priya khetan anthony abeyta lopez kena j lemu prachi meher brigitte allard katherine s james anne marie w turner david m margolis nancie m archin cristina ceriani priya khetan anthony abeyta lopez kena j lemu prachi meher brigitte allard katherine s james anne marie w turner david m margolis nancie m archin view text pdf impact of specific ligands and hiv latency reversal agents on estrogen receptor alpha in cd4 t cells text pdf abstract the estrogen receptor is hypothesized to directly influence hiv transcription and latency but is also critical for immune signaling however the mechanisms of action of the estrogen receptor er in immune cells in the context of hiv are limited and relevant to hiv cure strategies the influence of latency reversal agents lras on the er pathway are unknown we evaluated a the impact of estrogen e2 on the nuclear translocation of estrogen receptor α erα in cd4 t cells b the ability of fulvestrant a selective estrogen receptor degrader serd and arv 471 a novel potent proteolysis targeting chimera protac selective erα degrader to modulate er and c the impact of different classes of lras on er signaling in contrast to what has been demonstrated in oncology e2 does not induce erα nuclear translocation in cd4 t cells similarly neither fulvestrant nor arv 471 induced degradation of erα in cd4 t cells lras significantly downregulated erα gene and protein expression in both pbmcs and cd4 t cells collectively our results suggest that estrogen influences on hiv transcription are not likely a consequence of canonical nuclear erα mechanisms the consequences of lra downregulation of er a protein important for immune signaling warrants further investigation authors cristina ceriani priya khetan anthony abeyta lopez kena j lemu prachi meher brigitte allard katherine s james anne marie w turner david m margolis nancie m archin a distinct form of fat fibrosis is linked to insulin resistance in people with hiv diana l alba alaa abdellatif moon k choi stephen m brown mayfield thuy an t pham david i berrios antonio e rodriguez marin ewing tony r figueroa judy gonzalez vargas ningyan zhang zhiqiang an dawei bu steven g deeks philipp e scherer peter w hunt suneil k koliwad diana l alba alaa abdellatif moon k choi stephen m brown mayfield thuy an t pham david i berrios antonio e rodriguez marin ewing tony r figueroa judy gonzalez vargas ningyan zhang zhiqiang an dawei bu steven g deeks philipp e scherer peter w hunt suneil k koliwad view text pdf a distinct form of fat fibrosis is linked to insulin resistance in people with hiv text pdf abstract background despite antiretroviral therapy art people with hiv pwh are at heightened risk for insulin resistance ir and type 2 diabetes t2d subcutaneous adipose tissue sat fibrosis contributes to metabolic disease but its role in ir among pwh is unknown we investigated the relationship between sat fibrosis and ir in pwh along with transcriptional signatures to distinguish it from sat fibrosis due to obesity methods we analyzed body composition and sat fibrosis hydroxyproline in 46 pwh and 74 people without hiv pwoh excluding individuals with t2d we examined fibrosis related gene transcription in the sat using a targeted panel and measured plasma endotrophin a marker of extracellular matrix ecm remodeling results pwh had substantially more sat fibrosis than pwoh notably in non obese individuals moreover sat fibrosis in these pwh was strongly associated with ir independently of prior legacy art or ongoing integrase strand inhibitor treatment this sat fibrosis was highlighted by a distinct transcriptional pattern marked by upregulation of col14a1 key immune related genes e g ccl4 nlrp3 and pathways governing ecm remodeling and immune activation as well as downregulation of thermogenic lipid metabolic and insulin signaling pathways plasma endotrophin levels were also elevated in pwh and correlated independently with sat fibrosis conclusion sat fibrosis was associated with ir independent of obesity in pwh and was mirrored by circulating endotrophin levels offering a plausible noninvasive biomarker for early intervention the distinct transcriptional signature of hiv associated sat fibrosis highlights candidate mechanisms that may underlie metabolic risk and offer therapeutic avenues in this population authors diana l alba alaa abdellatif moon k choi stephen m brown mayfield thuy an t pham david i berrios antonio e rodriguez marin ewing tony r figueroa judy gonzalez vargas ningyan zhang zhiqiang an dawei bu steven g deeks philipp e scherer peter w hunt suneil k koliwad identification of distinct hiv reservoir phenotypes and associated immune landscapes ruoyu wang aparna b bhattacharyya lily pohlenz erin n shirk hayley s romero katherine haas jennifer m coughlin raha m dastgheyb leah h rubin rebecca t veenhuis ruoyu wang aparna b bhattacharyya lily pohlenz erin n shirk hayley s romero katherine haas jennifer m coughlin raha m dastgheyb leah h rubin rebecca t veenhuis view text pdf identification of distinct hiv reservoir phenotypes and associated immune landscapes text pdf abstract virally suppressed people with hiv pwh remain at risk for developing comorbidities due to chronic inflammation with one potential contributor being the hiv reservoir associations between the...