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massilani lab ancient dna at yale university diyendo massilani yale edu news research publications team alumni values contact select page ancient dna at yale university we investigate the evolutionary history of modern and extinct human populations using ancient dna our focus is to retrieve and sequence dna from archaeological materials to study the peopling of the world the history of human health and their adaptation to different environments and lifestyle conditions news phd opportunities in our lab through yale s human genome science track by diyendo massilani aug 1 2025 announcement we re excited to announce that our lab is now an affiliate of the human genome sciences graduate picnic and portrais lab spring summer event by diyendo massilani jul 3 2025 lab culture to celebrate the transition from spring to summer this year we gathered for a lovely picnic at we re delighted to welcome max levy as a new research intern by diyendo massilani jun 16 2025 announcement max comes to us from princeton day school where he studied biology from 2022 on his project older news entries research peopling of the world we generate genome wide data from ancient bones and sediments in different locations that have been inhabited by humans throughout history and link different ancient human lineages to specific temporal and geographic locations and environments the goal is to uncover genealogical relationships migration routes diversification events and genetic admixtures that shaped present day human diversity we are combining dna data from archaeological bones and sediments to generate high resolution time series ancient genetic data from different point through time in space with a particular focus on under sampled regions of the world such as east eurasia or africa adaptation modern human successfully spread across the world and colonized tropical to arctic high to low altitudes environments and adapted to different lifestyles this success relied on new mutations standing genetic variations or introgressed variations through admixture between different human groups including archaic neanderthals and denisovans we use ancient dna from archaeological bones and sediments to investigate the origin of genetic variants targeted by selection and their association with adaptations to lifestyles and environments our goal is to link presence absence and frequencies changes of specific allele to specific events in historic and prehistoric time and uncover details about the history of human health and the origins and evolution of several adaptative traits adaptation modern human successfully spread across the world and colonized tropical to arctic high to low altitudes environments and adapted to different lifestyles this success relied on new mutations standing genetic variations or introgressed variations through admixture between different human groups including archaic neanderthals and denisovans we use ancient dna from archaeological bones and sediments to investigate the origin of genetic variants targeted by selection and their association with adaptations to lifestyles and environments our goal is to link presence absence and frequencies changes of specific allele to specific events in historic and prehistoric time and uncover details about the history of human health and the origins and evolution of several adaptative traits methods for ancient dna past organisms left traces of their dna in their environment which can be preserved from hundred thousand of years in sediments independent of their physical remains the use of archaeological sediment as source of ancient dna allows to generate genetic data of human and other organisms at sites and in regions where bone remains are not found are rare or cannot be accessed our goal is to develop state of the art genetic and genomic approaches to better understand the factors that impact dna preservation in different type of archaeological material with a particular emphasis on sediment and expand the use of sediment dna for palaeogenetic research publications double or nothing ancient duplications in the amylase locus drove human adaptation pdf charting a landmark driven path forward for population genetics and ancient dna research in africa pdf microstratigraphic preservation of ancient hominin and faunal dna in pleistocene cave sediments pdf earliest evidence for denisovans identified using peptide mass fingerprinting and mitochondrial dna analysis pdf denisovan ancestry and population history of early east asians pdf compound specific radiocarbon dating and mitochondrial dna analysis of the pleistocene hominin from salkhit mongolia pdf past climate changes population dynamics and the origin of bison in europe pdf library construction for ancient genomics single strand or double strand pdf all publications team principal investigator assistant professor of genetics diyendo massilani i have always been curious about the diversity of traits in present day people which led to my fascination with the genetic mechanisms of heredity and their influence on human features throughout my scientific and personal journey across gabon france germany and the us i have integrated diverse cultural social and political perspectives continually fueling my determination to explore the evolution of humankind through the study of dna the key to our individuality and shared humanity diyendo s page postgraduate associate nih prep scholar phoebe demers a passion for the preservation of the natural world fuels my ambition to contribute to the fields of conservation genetics and de extinction i am eager to apply my background in biomedical engineering to the study of ancient dna which i aspire to use to guide rewilding efforts of endangered species phoebe s page postdoctoral associate michael james boyle i use ancient dna from sediments of archaeological sites to reconstruct early human population history sediments also contain dna from other organisms revealing the composition of ancient ecological communities and providing insight into the environment of early humans my research also explores how changes in the frequency of dna sequence variants potentially in response to changes in the environment shaped human adaptation and impacted our traits michael s page graduate student shahar silverman before coming to yale i conducted research on bacterial defense mechanisms and the microbiome i m very interested in host pathogen interactions and how pathogens drive their hosts evolution i am excited to learn about ancient dna research and to apply my background in microbiology to this field shahar s page postgraduate associate edward habeck iv my undergraduate research involved analyzing bacterial taxa in soils and skeletal material to study the microbial composition of archaeological proveniences and ancient human microbiomes i am fascinated by humans as reflections of our environment particularly how our lifestyle behavioral and physiological adaptations provide us with the distinctive resilience and diversity that characterizes our species ancient dna is an incredible resource for reconstructing past lives and experiences and every fragment acts as a unique component of our evolutionary puzzle my foremost goal is to pursue a phd with direct emphasis on ancient dna and i dream of contributing to our understanding of what it means to be human i m thrilled to be a member of the massilani lab at yale and i hold immense gratitude for the opportunity to delve into my greatest interest edward s page postgraduate associate misheelt bayarsaikhan the exciting field of studying the health and diseases of past populations through skeletal analysis sums up the focus of what i do in paleopathology in my work i act as an archaeologist and bioanthropologist from mongolia and i specialize in the study of ancient human remains i m also deeply interested in ancient dna and laboratory based approaches i am grateful to be here in the massilani lab at yale i am eager to begin a new chapter in my career misheelt s page yale pathways research intern eleanor law this is my first experience in a lab environment and i am learning new things about biology and genetics each day from my mentor shahar as well as my fellow lab mates working in a lab has been an amazing experience allowing me to get a hands on understanding of the incredible capabilities of science in deciphering ancient human dna eleanor s page alumni values the massilani lab ought to represent the cultural blend of our society my mentorship philosophy is to build a cordial open and trusting work environment where people can freely express their authentic self and opinions as a scientist i believe that the freedom to be our authentic selves brings depth and meaning to our interactions and fosters a shared investment and commitment that will benefit our science tremendously i want to build an inclusive team where every member feels responsible for maintaining a safe and equitable work environment for all as a mentor i will provide to my lab member the support they need to have an equitable access to opportunities regardless of their background their ethnicity country of origin physical and mental abilities gender and sexual orientation my goal is to foster intellectual and personal freedom as a mean to promote talent creativity and growth contact 1 203 785 3767 diyendo massilani yale edu follow follow post address massilani lab yale genetics po box 208 005 new haven ct 06520 8005 address massilani lab 333 cedar street sterling hall of medicine i wing rooms 225 219 234c new haven ct 06510 usa disclaimer