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antiaromatic some practice problems antiaromatic compounds and antiaromaticity the pi molecular orbitals of benzene the pi molecular orbitals of cyclobutadiene frost circles aromaticity practice quizzes 19 reactions of aromatic molecules electrophilic aromatic substitution introduction activating and deactivating groups in electrophilic aromatic substitution electrophilic aromatic substitution the mechanism ortho para and meta directors in electrophilic aromatic substitution understanding ortho para and meta directors why are halogens ortho para directors disubstituted benzenes the strongest electron donor wins electrophilic aromatic substitutions 1 halogenation of benzene electrophilic aromatic substitutions 2 nitration and sulfonation eas reactions 3 friedel crafts acylation and friedel crafts alkylation intramolecular friedel crafts reactions nucleophilic aromatic substitution nas nucleophilic aromatic substitution 2 the benzyne mechanism reactions on the benzylic carbon bromination and oxidation the wolff kishner clemmensen and other carbonyl reductions more reactions on the aromatic sidechain reduction of nitro groups and the baeyer villiger aromatic synthesis 1 order of operations synthesis of benzene derivatives 2 polarity reversal aromatic synthesis 3 sulfonyl blocking groups birch reduction synthesis 7 reaction map of benzene and related aromatic compounds aromatic reactions and synthesis practice electrophilic aromatic substitution practice problems 20 aldehydes and ketones what is the alpha carbon in carbonyl compounds nucleophilic addition to carbonyls aldehydes and ketones 14 reactions with the same mechanism sodium borohydride nabh4 reduction of aldehydes and ketones grignard reagents for addition to aldehydes and ketones wittig reaction hydrates hemiacetals and acetals imines properties formation reactions and mechanisms all about enamines breaking down carbonyl reaction mechanisms reactions of anionic nucleophiles part 2 aldehydes ketones reaction practice 21 carboxylic acid derivatives nucleophilic acyl substitution with negatively charged nucleophiles addition elimination mechanisms with neutral nucleophiles including acid catalysis basic hydrolysis of esters saponification transesterification proton transfer fischer esterification carboxylic acid to ester under acidic conditions lithium aluminum hydride lialh4 for reduction of carboxylic acid derivatives lialh ot bu 3 for the reduction of acid halides to aldehydes di isobutyl aluminum hydride dibal for the partial reduction of esters and nitriles amide hydrolysis thionyl chloride socl2 and conversion of carboxylic acids to acid halides diazomethane ch2n2 carbonyl chemistry learn six mechanisms for the price of one making music with mechanisms padped carboxylic acid derivatives practice questions 22 enols and enolates keto enol tautomerism enolates formation stability and simple reactions kinetic versus thermodynamic enolates aldol addition and condensation reactions reactions of enols acid catalyzed aldol halogenation and mannich reactions claisen condensation and dieckmann condensation decarboxylation the malonic ester and acetoacetic ester synthesis the michael addition reaction and conjugate addition the robinson annulation haloform reaction the hell volhard zelinsky reaction enols and enolates practice quizzes 23 amines the amide functional group properties synthesis and nomenclature basicity of amines and pkah 5 key basicity trends of amines the mesomeric effect and aromatic amines nucleophilicity of amines alkylation of amines sucks reductive amination the gabriel synthesis some reactions of azides the hofmann elimination the hofmann and curtius rearrangements the cope elimination protecting groups for amines carbamates the strecker synthesis of amino acids introduction to peptide synthesis reactions of diazonium salts sandmeyer and related reactions amine practice questions 24 carbohydrates d and l notation for sugars pyranoses and furanoses ring chain tautomerism in sugars what is mutarotation reducing sugars the big damn post of carbohydrate related chemistry definitions the haworth projection converting a fischer projection to a haworth and vice versa reactions of sugars glycosylation and protection the ruff degradation and kiliani fischer synthesis isoelectric points of amino acids and how to calculate them carbohydrates practice amino acid quizzes 25 fun and miscellaneous a gallery of some interesting molecules from nature screw organic chemistry i m just going to write about cats on cats part 1 conformations and configurations on cats part 2 cat line diagrams on cats part 4 enantiocats on cats part 6 stereocenters organic chemistry is shit the organic chemistry behind the pill maybe they should call them formal wins why do organic chemists use kilocalories the principle of least effort organic chemistry gifs resonance forms reproducibility in organic chemistry what holds the nucleus together how reactions are like music organic chemistry and the new mcat 26 organic chemistry tips and tricks common mistakes formal charges can mislead partial charges give clues about electron flow draw the ugly version first organic chemistry study tips learn the trends the 8 types of arrows in organic chemistry explained top 10 skills to master before an organic chemistry 2 final common mistakes with carbonyls carboxylic acids are acids planning organic synthesis with reaction maps alkene addition pattern 1 the carbocation pathway alkene addition pattern 2 the three membered ring pathway alkene addition pattern 3 the concerted pathway number your carbons the 4 major classes of reactions in org 1 how and why electrons flow grossman s rule three exam tips a 3 step method for thinking through synthesis problems putting it together putting diels alder products in perspective the ups and downs of cyclohexanes the most annoying exceptions in org 1 part 1 the most annoying exceptions in org 1 part 2 the marriage may be bad but the divorce still costs money 9 nomenclature conventions to know nucleophile attacks electrophile 27 case studies of successful o chem students success stories how corina got the the hard professor and got an a anyway how helena aced organic chemistry from a drop to b in org 2 how a hard working student turned it around how serge aced organic chemistry success stories how zach aced organic chemistry 1 success stories how kari went from c to b how esther bounced back from a c to get a s in organic chemistry 1 and 2 how tyrell got the highest grade in her organic chemistry course this is why students use flashcards success stories how stu aced organic chemistry how john pulled up his organic chemistry exam grades success stories how nathan aced organic chemistry without it taking over his life how chris aced org 1 and org 2 interview how jay got an a in organic chemistry how to do well in organic chemistry one student s advice america s top ta shares his secrets for teaching o chem organic chemistry is like a few metaphors how to do well in organic chemistry advice from a tutor guest post i went from being afraid of tests to actually looking forward to them always rigorous molecular orbital interactions in diels alder reactions often irreverent how do we know methane is tetrahedral occasionally profane organic chemistry is shit as seen on courtney e central washington university i stumbled across this website a couple years ago seeking help in preparation for my general chemistry acs exam and it was helpful then so i ve remembered it again and again for other classes and am glad i can use it again now for organic chemistry manuel e with nobel laureate kip thorne east los angeles college the study guides have helped me in so many angles that helped me improve my grades lessen my anxiety and improved my overall confidence thank you for taking the time to create such a useful tool and sell it for such an affordable cost matthew t colorado state university by the way 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dramatically case studies of successful students last semester i had the pleasure of working with chris a pseudonym on second semester organic chemistry topics before we met chris had already obtained a how helena got 93 in organic chemistry an australian reader helena recently wrote to say she d earned a 93 in her organic chemistry class as over the past few weeks i ve been corresponding with loyal reader serge who was happy to report to me recently that his exam grades are see more case studies from the blog march 6 2026 james ashenhurst org 1 midterm number 1 april 8 2026 james ashenhurst two step synthesis problems 20 solved examples august 20 2024 james ashenhurst spectroscopy and synthesis quizzes blog james ashenhurst founder master organic chemistry after doing a ph d in organic synthesis at mcgill and a postdoc at mit i applied for faculty positions at universities during the great recession it didn t work out but having seen first hand how many people struggled with the subject including mysel...