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co hkwi136e3b pic twitter com i2jqxxxdhx josh guetzkow joshg99 july 4 2022 wtf twitter reinstatejikkyleaks nao https t co hpbrbar59n mi_美知 overcatbe july 4 2022 quote are the covid mrna vaccines safe martin kulldorff brownstone institute featured posted by norman pilon in adverse events covid vaccines leave a comment tags adverse events of special insterst aesi dr christine benn et al joseph fraiman et al martin kulldorff pre defined brighton collaboration definitions hat tip jeffrey a tucker source brownstone institute by martin kulldorff a new scientific study entitled serious adverse events of special interest following mrna vaccination in randomized trials provides the best evidence yet concerning the safety of the mrna covid vaccines for most vaccines in common use benefits far outweigh risks but that may not be the case for the mrna covid vaccines according to this study by joseph fraiman and his colleagues it depends on your age and medical history the randomized controlled clinical trial is the gold standard of scientific evidence when regulators approved the pfizer and moderna mrna vaccines for emergency use in december 2020 two randomized trials showed that the vaccines reduced symptomatic covid infection by over 90 during the first few months after the second dose pfizer and moderna did not design the trials to evaluate long term efficacy or the more important outcomes of preventing hospitalization death or transmission the randomized trials did collect adverse event data including the presence of mild symptoms such as fever and more serious events requiring hospitalization or leading to death most vaccines generate some mild adverse reactions in some people and there were considerably more adverse such reactions after the mrna vaccines compared to the placebo continue reading this interpretation of the joseph fraiman et al study are the covid mrna vaccines safe martin kulldorff brownstone institute the bradford hill criteria cuz the cowards of causation denial need complete conversion slide by slide all criteria assessed dr jessica rose unacceptable jessica featured posted by norman pilon in adverse effects covid vaccines leave a comment tags athletes causation children coherence consilience consistency correlation dose response mechanism of action plausibility specificity temporality the bradford hill criteria source unacceptable jessica by jessica rose slide 1 the 10 bradford hill criteria the world health organization who requires that only 5 are satisfied to show evidence of causation i will use 10 slide 2 this is moderna s efficacy data that reveals safety issues the chi square test indicates a statistically significant difference between severe adverse events saes in placebo versus messenger rna mrna 1273 groups and it s messed up how 2 7 times higher rate for mrna arm sounds like old moderna needs to go back to the drawing board to me slide 3 r 1 means perfect correlation not by chance each dot is the number of doses disability per state slide 4 same but different continue reading the bradford hill criteria cuz the cowards of causation denial need complete conversion slide by slide all criteria assessed dr jessica rose unacceptable jessica amyloidogenesis of sars cov 2 spike protein sofie nyström and per hammarström journal of the american chemical society featured posted by norman pilon in covid vaccines covid 19 leave a comment tags amyloid disease blood coagulation fibrinolytic disturbances neurologic and cardiac problems the amyloidogenicity of the sars cov 2 spike protein s protein the sars cov 2 spike protein s protein norm s note reading this keep in mind that the mrna vaccines code for the the sars cov 2 spike protein s protein question is the bioactivity of transfected spike the same as that which comes with the virus i strongly suspect that it is hat tip amy lloyd osis and sp ke protein https t co y9mo3wog6b clucky clucky92864053 july 1 2022 source journal of the american chemical society read the pdf of the entire study here abstract sars cov 2 infection is associated with a surprising number of morbidities uncanny similarities with amyloid disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the sars cov 2 spike protein s protein amyloid fibril assays of peptide library mixtures and theoretical predictions identified seven amyloidogenic sequences within the s protein all seven peptides in isolation formed aggregates during incubation at 37 c three 20 amino acid long synthetic spike peptides sequence 192 211 601 620 1166 1185 fulfilled three amyloid fibril criteria nucleation dependent polymerization kinetics by tht congo red positivity and ultrastructural fibrillar morphology full length folded s protein did not form amyloid fibrils but amyloid like fibrils with evident branching were formed during 24 h of s protein coincubation with the protease neutrophil elastase ne in vitro ne efficiently cleaved s protein rendering exposure of amyloidogenic segments and accumulation of the amyloidogenic peptide 194 203 part of the most amyloidogenic synthetic spike peptide ne is overexpressed at inflamed sites of viral infection our data propose a molecular mechanism for potential amyloidogenesis of sars cov 2 s protein in humans facilitated by endoproteolysis the prospective of s protein amyloidogenesis in covid 19 disease associated pathogenesis can be important in understanding the disease and long covid 19 read the pdf of the entire study here video john ioannidis covid19 lecture 4 25 2022 vkprasadlab excess death when does the pandemic end featured posted by norman pilon in covid 19 leave a comment tags john ioannidis vinay prasad when does a pandemic end apr 25 2022 vinay prasad md mph physician associate professor google scholar https scholar google com citations substack https vinayprasadmdmph substack com podcast https podcasts apple com us podcast personal website http www vinayakkprasad com laboratory website http www vkprasadlab com podcast website http www plenarysessionpodcast com academic publications http www vinayakkprasad com papers quote an attempt to ridicule a preprint by peter doshi et al antivax misinformation shredded to pieces featured posted by norman pilon in adverse events covid vaccines propaganda 2 comments tags antivaxxers apples to oranges dr susan oliver fooled by p hacking and apples to oranges comparison peter doshi et al serious adverse events saes norm s note what follows is an unrolled twitter thread by dr norman fenton that you should be able to find here follow the links of course the preprint at issue can be found here 1 here s our detailed response to the drsusanoliver1 video praised by many who should know better which attempted to ridicule a preprint by bmj editor peter doshi et al on vaxx adverse reactions https probabilityandlaw blogspot com 2022 06 response to susan oliver video html 2 we welcome the responses of important influencers like profphansen and d_spiegel who were so impressed with the video the claims in it are highly misleading and rather offensive we show the evidence and a bayes reanalysis supports doshi et al 3 also posted here https www normanfenton com post response to susan oliver video antivaxxers fooled by p hacking and apples to oranges comparison originally tweeted by prof norman fenton profnfenton on july 1 2022 quote what s a conflict of interest oh i dunno featured posted by norman pilon in covid vaccines leave a comment tags brook jackson maryanne demasi regulatory capture hat tip are fda drug regulators for hire yes we can shut that down very easily https t co bffwcucpqo https t co duldsezvdk brook jackson iambrookjackson june 30 2022 from fda to mhra are drug regulators for hire bmj 2022 377 doi https doi org 10 1136 bmj o1538 published 29 june 2022 cite this as bmj 2022 377 o1538 patients and doctors expect drug regulators to provide an unbiased rigorous assessment of investigational medicines before they hit the market but do they have sufficient independence from the companies they are meant to regulate maryanne demasi investigates source the bmj quote just so you don t miss it serious adverse events of special interest following mrna vaccination in randomized trials joseph fraiman et al ssrn featured posted by norman pilon in covid vaccines covid 19 harm benefit analyses leave a comment tags hospitalization or death increased risk of serious adverse events of special interest pfizer and moderna mrna covid 19 vaccines source ssrn serious adverse events of special interest following mrna vaccination in randomized trials 22 pages posted 23 jun 2022 to read this preprint follow this link to the pdf serious adverse events of special interest following mrna vaccination in randomized trials joseph fraiman louisiana state university lallie kemp regional medical center juan erviti navarre health service mark jones bond university institute for evidence based healthcare sander greenland university of california los angeles ucla jonathan and karin fielding school of public health patrick whelan university of california at los angeles robert m kaplan stanford university peter doshi university of maryland school of pharmacy abstract introduction in 2020 prior to covid 19 vaccine rollout the coalition for epidemic preparedness innovations and brighton collaboration created a priority list endorsed by the world health organization of potential adverse events relevant to covid 19 vaccines we leveraged the brighton collaboration list to evaluate serious adverse events of special interest observed in phase iii randomized trials of mrna covid 19 vaccines methods secondary analysis of serious adverse events reported in the placebo controlled phase iii randomized clinical trials of pfizer and moderna mrna covid 19 vaccines nct04368728 and nct04470427 focusing analysis on potential adverse events of special interest identified by the brighton collaboration results pfizer and moderna mrna covid 19 vaccines were associated with an increased risk of serious adverse events of special interest with an absolute risk increase of 10 1 and 15 1 per 10 000 vaccinated over placebo baselines of 17 6 and 42 2 95 ci 0 4 to 20 6 and 3 6 to 33 8 respectively combined the mrna vaccines were associated with an absolute risk increase of serious adverse events of special interest of 12 5 per 10 000 95 ci 2 1 to 22 9 the excess risk of serious adverse events of special interest surpassed the risk reduction for covid 19 hospitalization relative to the placebo group in both pfizer and moderna trials 2 3 and 6 4 per 10 000 participants respectively discussion the excess risk of serious adverse events found in our study points to the need for formal harm benefit analyses particularly those that are stratified according to risk of serious covid 19 outcomes such as hospitalization or death note funding information this study had no funding support video dr peter mccullough md mph jun 27 2022 texas senate hhs testimony featured posted by norman pilon in covid vaccines covid 19 leave a comment tags censorship and reprisal dr peter mccullough early treatment texas senate hhs testimony peter a mccullough md mph texas senate testimony health and human services committee lessons learned on pandemic response june 27 2022 senator lois kolkhorst chair intramyocardial inflammation after covid 19 vaccination an endomyocardial biopsy proven case series christian baumeier et al mdpi open access journals featured posted by norman pilon in adverse events covid vaccines myocarditis leave a comment tags autoimmunological myocardial damage expression of sars cov 2 spike protein within the heart christian baumeier et al sandeep chakraborty hat tip sandeep chakraborty at long last germany shows the expression of sars cov 2 spike protein within the heart of most patients with myocarditis both mrna and adenovec vax a bad idea to have our own cells make foreign proteins leading to as they say autoimmunological myocardial damage https t co 2mcklqnegq pic twitter com ytah4ld1b5 sandeep chakraborty sanchak74 june 29 2022 source mdpi open access journals intramyocardial inflammation after covid 19 vaccination an endomyocardial biopsy proven case series by christian baumeier 1 ganna aleshcheva 1 dominik harms 1 ulrich gross 1 christian hamm 2 3 birgit assmus 3 ralf westenfeld 4 malte kelm 4 spyros rammos 5 philip wenzel 6 thomas münzel 6 albrecht elsässer 7 mudather gailani 8 christian perings 9 alae bourakkadi 10 markus flesch 11 tibor kempf 12 johann bauersachs 12 felicitas escher 1 13 14 and heinz peter schultheiss 1 1 institute of cardiac diagnostics and therapy ikdt gmbh 12203 berlin germany 2 kerckhoff heart center department of cardiology 61231 bad nauheim germany 3 department of cardiology and angiology universitätsklinikum gießen und marburg 35391 gießen germany 4 department of cardiology pulmonology and vascular medicine heinrich heine university düsseldorf 40225 düsseldorf germany 5 onassis cardiac surgery center 176 74 athens greece 6 department of cardiology university medical center mainz 55131 mainz germany 7 department of cardiology klinikum oldenburg 26133 oldenburg germany 8 frankenwaldklinik 96317 kronach germany 9 department of cardiology st marien hospital 44534 lünen germany 10 department of internal medicine cardiology geriatrics and palliative medicine gemeinschaftsklinikum mittelrhein ggmbh 56727 mayen germany show full affiliation list author to whom correspondence should be addressed academic editors loredana frasca and steven fiering int j mol sci 2022 23 13 6940 https doi org 10 3390 ijms23136940 received 8 april 2022 revised 20 may 2022 accepted 21 june 2022 published 22 june 2022 this article belongs to the special issue t regulatory cells in autoimmunity and transplantation abstract myocarditis in response to covid 19 vaccination has been reported since early 2021 in particular young male individuals have been identified to exhibit an increased risk of myocardial inflammation following the administration of mrna based vaccines even though the first epidemiological analyses and numerous case reports investigated potential relationships endomyocardial biopsy emb proven cases are limited here we present a comprehensive histopathological analysis of embs from 15 patients with reduced ejection fraction lvef 30 14 39 and the clinical suspicion of myocarditis following vaccination with comirnaty pfizer biontech n 11 vaxzevria astrazenica n 2 and janssen johnson johnson n 2 immunohistochemical emb analyses reveal myocardial inflammation in 14 of 15 patients with the histopathological diagnosis of active myocarditis according the dallas criteria n 2 severe giant cell myocarditis n 2 and inflammatory cardiomyopathy n 10 importantly infectious causes have been excluded in all patients the sars cov 2 spike protein has been detected sparsely on cardiomyocytes of nine ...