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in line process sensors for chromatography mettler toledo pendotech home products sensors and monitors single use pressure sensors pressuremat pressure sensor transmitter in line uv turbidity temperature sensors transmitters conductivity sensors transmitters single use ph sensors flow meters air in tube detector pendotech daq control systems filter screening system nff cross flow filtration tff system virus depth filtration system other products tubing throttle valve lab scale process vessels key applications bioreactor depth filtration tff crossflow filtration chromatography centrifugation filtration perfusion fill finish in biopharmaceutical manufacturing formulation support certificate of conformance search tool quality documents technical resources data sheets app notes tech notes video library pump scale configuration tips webinars usp faqs company about us contact us order form commercial terms conditions conference schedule oem login search mettler toledo pendotech chromatography chromatography for biopharmaceutical manufacturing why chromatography monitoring matters in bioprocessing chromatography is a critical downstream purification process in biopharmaceutical manufacturing used to isolate and purify monoclonal antibodies mabs recombinant proteins vaccines peptides plasmids and viral vectors across capture intermediate and polishing steps chromatography directly impacts product purity yield process efficiency and gmp compliance chromatography is also one of the most expensive downstream operations due to high resin replacement costs column qualification requirements long process cycle times product loss during breakthrough or elution cip sip validation requirements batch consistency expectations for biologics manufacturers cdmos and cell gene therapy facilities real time chromatography monitoring helps maximize resin utilization reduce deviation risk and maintain validated operating conditions air detector click here to learn more about our air detector accessory single use pressure sensors pendotech s single use pressure sensors measure static and dynamic pressure of gases and liquids in your biopharmaceutical processes accurately and cost effectively learn more pendotech single use uv absorbance sensors pendotech is proud to offer single use uv absorbance and turbidity measuring and monitoring tools that collect data from the stream while it is processing resulting in less disruption to bioprocessing operations compared to measurements taken off line learn more mass flowmeter pendotech flow meters and monitors are designed to deliver highly accurate flow measurements for bioprocessing applications different applications require different flow measurement technology and features learn more conductivity sensor pendotech s single use conductivity sensors and conductivity monitor integrate for highly accurate conductivity and temperature measurement without the need to calibrate the conductivity electode because of its predetermined cell constant learn more critical manufacturing risks without continuous in line monitoring chromatography systems are vulnerable to product breakthrough and yield loss resin fouling and reduced column lifespan buffer preparation errors flow instability and pressure excursions aggregation during low ph elution batch inconsistency across manufacturing campaigns increased deviation investigations and capas regulatory in line on line monitoring capture chromatography intermediate chromatography polishing summary fda gmp and ich compliance for chromatography chromatography processes must comply with fda process validation guidance stage 1 3 ich q8 q9 requirements for operating ranges and risk based controls gmp and 21 cfr part 11 requirements continuous monitoring of uv absorbance ph conductivity pressure and flow helps ensure chromatography processes remain within validated operating ranges while supporting batch consistency and impurity clearance trends over multiple cycles key performance indicators product recovery yield resin utilization efficiency breakthrough detection impurity clearance trends pressure stability across cycles benefits of continuous monitoring improved product yield real time uv and conductivity monitoring helps prevent premature breakthrough and product loss extended resin lifespan pressure trend monitoring identifies fouling early reducing unnecessary resin replacement costs faster batch release automated process data supports faster review by exception workflows reduced contamination risk single use sensor technologies eliminate cleaning validation requirements and reduce cross contamination risk improved process consistency continuous monitoring helps maintain validated process conditions across campaigns and scales high capacity product isolation and recovery capture chromatography is designed to isolate the target molecule from complex feed streams while removing bulk impurities such as host cell proteins dna media components and aggregates typical applications include protein a chromatography ion exchange chromatography affinity chromatography mixed mode chromatography key process parameters uv absorbance 280 nm tracks protein loading and detects breakthrough events before product loss occurs ph maintains optimal binding and elution conditions for sensitive biologics conductivity confirms buffer ionic strength and buffer exchange accuracy pressure and flow detect resin fouling column channeling bed compression filter blockage or packing inconsistencies common capture chromatography challenges resin fouling protein accumulation and contaminants reduce resin binding capacity and shorten resin life premature breakthrough column overloading causes product loss and reduced recovery yield aggregation during elution low ph elution conditions can cause aggregation or damage sensitive molecules including monoclonal antibodies fusion proteins viral vectors inconsistent buffer conditions incorrect conductivity or ph impacts binding efficiency and impurity clearance impurity reduction and process refinement intermediate chromatography steps further purify the target molecule by removing host cell proteins dna endotoxins aggregates leached protein a process related impurities monitoring priorities critical monitoring parameters include conductivity gradients buffer transitions pressure stability flow consistency uv peak resolution operational challenges manufacturers commonly face poor separation efficiency gradient inconsistencies resin degradation or fouling lowers resolution over time reduced impurity clearance over repeated cycles leading to more offline testing continuous monitoring improves process reproducibility and impurity control final product purification and quality assurance polishing chromatography provides the final purification stage before formulation and fill finish objectives polishing steps remove trace impurities aggregates charge variants residual contaminants while ensuring product potency stability regulatory compliance key monitoring parameters uv absorbance ph stability conductivity precision low differential pressure consistent flow distribution common risks subtle impurity carryover product dilution variability reduced separation efficiency final product specification failures real time process analytics help maintain consistent final product quality and reduce batch rejection risk summary table critical parameter why it matters monitoring technology best practice mitigation uv absorbance 280 nm detects breakthrough and confirms load endpoint in line uv detector set load endpoint using uv breakthrough curve avoid overloading resin ph ensures optimal binding elution in line single use ph sensor validate ph buffers adjust in line to maintain optimal binding elution conductivity verifies buffer identity ionic strength in line conductivity probe check conductivity before column correct deviations immediately pressure flow reveals fouling or packing channeling in line pressure and flow sensors monitor and control flow pressure to prevent channeling perform routine maintenance learn more learn about mettler toledo pendotech single use in line uv ph conductivity and pressure monitoring solutions that optimize chromatography performance extend resin life and deliver audit ready data for downstream viral clearance after achieving high purification and removal of process related impurities the next critical step is viral clearance a regulatory requirement to inactivate or remove potential viral contaminants and ensure patient safety products sensors monitors control systems other products key applications virus depth filtration tff crossflow filtration chromatography centrifugation filtration services product service recertification technical resources data sheets app notes tech notes industry resources articles press releases video library quick links contact us about us faqs copyright 2026 mettler toledo pendotech back to top