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plos computational biology skip to main content advertisement plos computational biology browse current issue journal archive collections find and read articles publish submissions getting started submission guidelines figures tables supporting information latex other article types preprints revising your manuscript submit now policies best practices in research reporting human subjects research animal research competing interests disclosure of funding sources licenses and copyright data availability code availability complementary research materials software and code sharing ethical publishing practice authorship corrections expressions of concern and retractions manuscript review and publication editorial and peer review process editor center guidelines for reviewers accepted manuscripts comments about journal information editors in chief editorial board publishing information publication fees press and media contact search search advanced search july 10 2026 welcome to plos computational biology image credit plos interested in joining the board plos computational biology is looking for new colleagues to join our exceptional team of editors apply 07 09 2026 research article mind the gap an embedding guide to safely travel in sequence space given the amino acid sequence of the original enzyme and a set of residues for which the local environment should be conserved i e the catalytic site the author s approach generates mutants that differ vastly in the overall sequence while retaining the geometry of the conserved region thereby representing promising candidates for further experimental screening image credit usgs recently published articles leveraging synthetic and genetic data to improve epidemic forecasting how host mobility formulations shape estimates of pathogen dispersal and epidemic risk in non endemic regions an in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity see all articles current issue july 2026 07 06 2026 research article extracting host specific developmental signatures from longitudinal microbiome data longitudinal microbiome studies provide critical insights into microbial community dynamics and their relation to host health tensor decompositions offer a powerful framework for the unsupervised analysis of such data yielding interpretable low dimensional temporal patterns however existing approaches based on the cp model assume common temporal dynamics for all subjects and therefore cannot capture subject specific trajectories image credit sean sinclair 06 22 2026 research article integrative modelling of innate immune response dynamics during virus infection understanding the dynamic interaction between the viral life cycle and immune signaling is crucial to designing effective antiviral strategies although significant progress has been made quantitative models that can accurately capture the intricate interactions and the intertwined dynamics during viral infection of cells remain missing image credit boddepalli et al 06 22 2026 research article towards modelling phage therapy patients with dangerous antibiotic resistant bacteria have been treated with mixtures of bacteriophages viruses that infect bacteria this treatment is highly personalized because the right phages must be selected for each patient s infection since bacteria quickly evolve resistance to phages it is often unclear why a treatment works or fails and how to design the best phage combinations image credit de boer schooley and perelson 06 23 2026 education ten simple rules for writing a peer review while many years are spent increasing our scientific expertise the training that is needed on how exactly to review these important documents is often learned through practice at times with little guidance in addition to those new to the process senior graduate students all the way to junior faculty members seeking guidance on how to approach the task of peer review image credit andre william 06 16 2026 research article environmental knees and wiggles as strong stabilizers of species range limits set by interspecific competition whether interspecific competition is a major contributing factor to setting species range limits has been debated for a long time theoretical studies have proposed that the interactions between interspecific competition and disruptive gene flow along an environmental gradient can halt range expansion of ecologically image credit bailey zindel 05 13 2026 research article art s hidden topology a window into human perception for decades scientists have tried to understand why certain works of art move us more than others yet directly connecting what is in an image to how it makes us feel has proven elusive image credit dmitruk et al 05 13 2026 research article a multi frequency whole brain neural mass model with homeostatic feedback inhibition macroscale brain activity can be captured using techniques like eeg and fmri however the granular or more detailed activity of neurons and localized neural masses is inaccessible image credit coronel oliveros et al 05 11 2026 methods schilda hierarchical integration of llm with kg database for single cell type annotation cell type annotation in single cell rna sequencing is a critical bottleneck with existing automated methods facing limitations in accuracy interpretability and generalization to novel cell types image credit li et al 04 03 2026 education training biologists in unix command line skills from curriculum to interactive online tutorials as data generation continues to accelerate the life science and health communities are facing a growing need to master core bioinformatics skills image credit kimberly farmer collections topic pages this collection aims to increase the coverage of computational biology related topics in wikipedia by rewarding authors with a citable pubmed indexed static version of the living document on wikipedia developing computational biology this series of perspective articles from computational biologists in a variety of countries offers their personal viewpoint on the history current status and future of computational biology in their region education this collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions as well as resources for training scientists at all stages of their careers benchmarking the benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems of other plos content plos biology knowledge guided analysis of omics data using the knoweng cloud platform plos neglected tropical diseases test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for cutaneous leishmaniasis cl in patients with clinical or epidemiological suspicion of cl systematic review and meta analysis plos pathogens murine and related chapparvoviruses are nephro tropic and produce novel accessory proteins in infected kidneys plos medicine prevalence and genetic profiles of isoniazid resistance in tuberculosis patients a multicountry analysis of cross sectional data of publish with plos submission instructions submit your manuscript connect with us contact us rss plos computational biology on bluesky plos on facebook plos blogs get new content from plos computational biology in your inbox plos will use your email address to provide content from plos computational biology you can find out more about how plos processes your data by reading our privacy policy you can unsubscribe at any time by clicking the unsubscribe link in our emails or by contacting us at privacy plos org plos computational biology issn 1553 7358 online publications plos aging and health plos biology plos climate plos complex systems plos computational biology plos digital health plos ecosystems plos genetics plos global public health plos medicine plos mental health 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