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description=APRETUDE, long-acting injectable PrEP for HIV-1–negative at-risk adults & adolescents weighing at least 77 lbs. See Prescribing Info & Boxed Warning.;

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long acting prep apretude cabotegravir you are leaving this site you are about to leave a viiv healthcare website by clicking this link you will be taken to a website that is independent from viiv healthcare the site you are linking to is not controlled or endorsed by viiv healthcare and viiv healthcare is not responsible for the content provided on that site accept cancel apretude is given every other month by a healthcare provider after initiation injections have been given 1 month apart for 2 consecutive months stay under a provider s care while receiving apretude you must receive it as scheduled if you will miss a scheduled injection by more than 7 days call your provider right away share your experience if you are 18 years or older please call viiv healthcare to find out more about sharing your story 1 888 203 9565 pmus cbtwcnt240118 important safety information what is the most important thing i should know about apretude important information for people who receive apretude for pre exposure prophylaxis prep to help reduce their risk of getting human immunodeficiency virus 1 hiv 1 infection before receiving apretude to reduce your risk of getting hiv 1 you must be hiv 1 negative to start apretude do not receive apretude unless you are tested and confirmed to be hiv 1 negative some hiv 1 tests can miss hiv 1 infection in a person who has recently become infected tell your healthcare provider if you had a flu like illness within the last month before starting or at any time while receiving apretude symptoms of new hiv 1 infection include tiredness joint or muscle aches sore throat rash enlarged lymph nodes in the neck or groin fever headache vomiting or diarrhea or night sweats while you are receiving apretude for hiv 1 prep apretude does not prevent other sexually transmitted infections stis practice safer sex by using a latex or polyurethane condom to reduce the risk of getting stis you must stay hiv 1 negative to keep receiving apretude for hiv 1 prep know your hiv 1 status and the hiv 1 status of your partners if you think you were exposed to hiv 1 tell your healthcare provider right away your risk of getting hiv 1 is lower if your partners with hiv 1 are taking effective treatment get tested for hiv 1 with each apretude injection or when your healthcare provider tells you you should not miss any hiv 1 tests if you become hiv 1 infected and continue receiving apretude because you do not know you are hiv 1 infected the hiv 1 infection may become harder to treat get tested for other stis these infections make it easier for hiv 1 to infect you talk to your healthcare provider about ways to reduce your hiv 1 risk do not miss any injections of apretude missing injections increases your risk of getting hiv 1 infection who should not receive apretude do not receive apretude if you already have hiv 1 or do not know your hiv 1 status if you are hiv 1 positive you need to take other medicines to treat hiv 1 apretude can only help reduce your risk of getting hiv 1 infection before you are infected if you have hiv 1 and receive only apretude over time your hiv 1 may become harder to treat are allergic to cabotegravir are taking certain medicines carbamazepine oxcarbazepine phenobarbital phenytoin rifampin or rifapentine what are the possible side effects of apretude apretude may cause serious side effects allergic reactions call your healthcare provider right away if you develop a rash with apretude stop receiving apretude and get medical help right away if you develop a rash with any of the following signs or symptoms fever generally ill feeling tiredness muscle or joint aches trouble breathing blisters or sores in mouth blisters redness or swelling of the eyes swelling of the mouth face lips or tongue liver problems liver problems have happened in people with or without a history of liver problems or other risk factors call your healthcare provider right away if you have any of the following symptoms your skin or the white part of your eyes turns yellow dark or tea colored urine light colored stools nausea or vomiting loss of appetite pain aching or tenderness on the right side of your stomach area or itching depression or mood changes call your healthcare provider or get emergency medical help right away if you develop any of the following symptoms feeling sad or hopeless feeling anxious or restless have thoughts of hurting yourself suicide or have tried to hurt yourself the most common side effects of apretude include pain tenderness hardened mass or lump swelling bruising redness itching warmth loss of sensation at the injection site abscess and discoloration diarrhea headache fever tiredness sleep problems nausea dizziness passing gas stomach pain vomiting muscle pain rash loss of appetite drowsiness back pain or upper respiratory infection these are not all the possible side effects of apretude call your healthcare provider for medical advice about side effects before receiving apretude tell your healthcare provider about all your medical conditions including if you have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir have or have had liver problems have ever had mental health problems are pregnant or plan to become pregnant it is not known if apretude will harm your unborn baby apretude can remain in your body for up to 12 months or longer after the last injection tell your healthcare provider if you become pregnant while or after receiving apretude are breastfeeding or plan to breastfeed apretude may pass into your breast milk talk with your healthcare provider about the best way to feed your baby while or after receiving apretude tell your healthcare provider about all the medicines you take including prescription and over the counter medicines vitamins and herbal supplements some medicines may interact with apretude keep a list of your medicines and show it to your healthcare provider and pharmacist do not start a new medicine without telling your healthcare provider how will i receive apretude apretude will be given to you as an injection by your healthcare provider apretude is initially given as an injection into the muscle of your buttock 1 time every month for the first 2 months then as an injection 1 time every 2 months before receiving your first apretude injection your healthcare provider may have you take 1 oral cabotegravir tablet 1 time a day for 1 month at least 28 days to assess how well you tolerate cabotegravir apretude is a long acting medicine and may stay in your body for 12 months or longer after your last injection stay under the care of a healthcare provider while receiving apretude it is important that you receive apretude as scheduled if you miss or plan to miss a scheduled injection of apretude by more than 7 days call your healthcare provider right away to discuss your prep options if you stop receiving apretude talk to your healthcare provider about other options to reduce the risk of getting hiv 1 infection _ bottomtext2 you are encouraged to report negative side effects of prescription drugs to the fda visit www fda gov medwatch or call 1 800 fda 1088 you may also report negative side effects to viiv at www gsk public reportum com or 1 877 844 8872 please read the patient information for apretude including an important warning and discuss it with your healthcare provider pmus cbtwcnt240120 trademarks are owned by or licensed to the viiv healthcare group of companies you are encouraged to report negative side effects of prescription drugs to the fda visit www fda gov medwatch or call 1 800 fda 1088 you may also report negative side effects to viiv at www gsk public reportum com or 1 877 844 8872 please read the patient information for apretude including an important warning and discuss it with your healthcare provider pmus cbtwcnt240120 trademarks are owned by or licensed to the viiv healthcare group of companies this website is funded and developed by viiv healthcare this site is intended for us residents only 2026 viiv healthcare or licensor pmus cbtwcnt260020 june 2026 produced in usa