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ricas 264 australasia 44 communication 525 art 63 books 146 technical communication 20 visual communication 48 culture 54 economics 12 education 34 entertainment 44 environment 20 europe 43 events 34 food 13 health 69 history 72 humor 482 lol 21 lolcats 14 law 27 mathematics 7 medicine 111 safety 32 music 14 nature 36 people 990 pets 25 politics 91 religion 427 personal 24 project management 3 pseudoscience 166 science 1 355 biology 190 evolution 102 chemistry 7 stc 2 technology 164 transport 8 travel 22 uncategorized 982 web 116 world 137 science notes new ish hindenburg footage nobel prize for medicine mrna research tree or grass allergies weather network gallery where would we be without axial tilt white supremacists in u s police forces greeting cards for the holidays the 1918 flu pandemic sympathy for the devil rand paul and mandatory vaccination animalcules animals art asia astronomy authors biology birds blog carnivals books canada cats celebration cephalopods climate communication creationism culture deep time dinosaurs diseases ecology economics education europe evolution fish fossils genetics geology health heroes history humor intelligent design invertebrates jerks language lol lolcats mammals marine life mathematics medicine molluscs movies museums neuroscience nutrition online resources people physics plants politics pseudoscience pz myers quotations religion research rhetoric science science writing scientific method sex skepticism software space tangled bank technical communication technology u s visual communication weather web world my library at librarything pages about lotstreetwiz about monado blogroll books quotations about religion an atheist s creed books about science vs religion secular and agnostic prayers theology resources blog archives creation stories holocaust history molecular evolution and michael behe provocative posts skepticism and critical thinking technical communication links technorati add to technorati favorites top posts the murder of larry hooper misquoting random dead french scientists sympatric speciation by polyploidy nine year old organizes gay rights rally in denver how are are minds shaped white coat underground leaves scienceblogs canadian shield seed magazine on avian flu religion and crime zombie snail flickr photos more photos simon singh has won send money anti vaccine toll u s colours of blood october 29 2014 monado did you know that some organisms have violet blood it s all in the d orbitals i understand read about blood chemistry and see a larger diagram iron makes red or green or violet while copper makes blue share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in science tags biochemistry biology leave a comment what is squalene anyway december 18 2013 monado the short answer is given here in the organic molecule directory alkenes page squalene is found in shark liver oil and is also a major component of the lipids on the surface of human skin although it is not obvious from the way the structure above is drawn squalene is a precursor for the biosynthesis of cholesterol through a complex series of enzymatically controlled reactions squalene is converted into an intermediate called lanosterol which undergoes a number of subsequent reactions to become cholesterol here is what the molecule looks like every angle or terminus has a carbon atom with enough hydrogen atoms to fill the unused bonds up to carbon s complement of four per atom a double line indicates a double bond share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in medicine science tags biochemistry vaccines leave a comment in memoriam frederick sanger november 21 2013 monado frederick sanger the only briton to have won two nobel prizes has died he worked in biochemistry studying dna and proteins his first nobel prize was awarded for being the first to sequence a protein insulin at the time it required years of work to do so he found that it was made up of two peptide chains all proteins are one or more peptide chains he spent nearly ten years removing one amino acid at a time from the end of the protein and identifying it then going on to the next winning the prize enabled him to afford better facilities and gather bright students around him his second prize was for an ingenious and efficient way of discovering the sequence of nucleotide bases in a molecule of dna or rna the linking of base pairs gives the molecule its ladder structure the sanger method cuts the molecules at different places sorts them by weight and therefore length and identifies the base on the end using fluorescent dyes of different colours according to wikipedia he used the method sequence human mitochondrial dna 16 569 base pairs and bacteriophage λ 48 502 base pairs his method was used to sequence the human genome and many others his work allowed us to understand the genetic basis of mutations and diseases and was important for the development of better vaccines frederick sanger was also honoured with the order of merit for distinguished service in science as well as several other awards the telegraph has quite a nice obituary frederick sanger share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in people science tags biochemistry celebration heroes people leave a comment giant viruses join as another ancestral superkingdom september 17 2012 monado mimivirus in amoeba credit professor didier raoult rickettsia laboratory la timone marseille france a study of the proteins of giant viruses adds them to the list of primitive life forms that have existed since the dawn of life they seem to constitute a fourth superkingdom professor gustavo caetano anollés led the analysis scientists found ancient structural patterns in the folds of the virus proteins which are virtually molecular fossils folds that are common to all organisms studied are the oldest less common folds are literally new wrinkles the researchers looked at archaea bacteria eukaryotes and both kinds of viruses the giant viruses have biochemistry for making proteins which small viruses have lost modern viruses have lost much of their biochemical machinery and become obligate parasites of an extreme kind giant viruses coexisted with the cellular ancestors and represent a distinct supergroup along with superkingdoms archaea bacteria and eukarya share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in biology evolution science tags biochemistry microbiology molecular evolution peer reviewed research viruses 3 comments aphids can make carotenoids to capture solar energy august 22 2012 monado aphids aphids can make their own carotenoids and may be able to capture chemical energy directly from the sun green or orange individuals contain more carotenoids and more atp than white ones the secret of plant growth is that they capture photons and use them to create high energy atomic bonds that can be used elsewhere to run chemical reactions that build plant material unlike other organisms they are not ingesting or otherwise harbouring photosynthetic symbionts such as bacteria or algae they are making their own photosynthetic chemicals they may not be able to do full photosynthesis as plants do but among animals they are unique it will be interesting to find out how they evolved this unique for animals biochemical machinery share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in biology science tags biochemistry insects plants leave a comment transitional forms muscle proteins february 13 2012 monado how old is evolution how conservative try this the proteins that an amoeba ameba uses to move are essentially the same as those that make up the muscle fibres in a vertebrate such as ourselves though it appears to have nothing in common with muscular movement ameboid movement probably depends on contractile components and mechanisms surprisingly similar to those in the muscle cells of animals t he cytoplasm of an ameba is found to contain thick and thin microfilaments similar in appearance and dimensions to thick myosin and thin actin microfilaments of striated muscle extracts of muscle myosin appear to cross react with the thin filaments from amebas and cytoplasm from amebas uses the nucleotide adenosine triposphate atp as an energy source for movement as muscle does from living invertebrates page 27 chapter on protozoans by vicki pearse john pearse mildred buschbaum ralph buschbaum share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in biology evolution science tags biochemistry evolution leave a comment evolution of complexity in molecular machines january 11 2012 monado v atpase proton pump and evolutionary pathway a proton pump is a ring of proteins embedded in a cell wall which moves molecules atoms or ions through the wall in a preferred direction research into the v atpase proton pump in eukaryotes has a ring of six linked protein molecules in the membrane wall and a ring of eight inside the cell as its name implies it moves hydrogen ions protons through the cell wall research into its history shows that greater complexity can evolve without a change in function the v indicates a plant vacuolar pump they are found not in the external cell wall but in the walls of vacuoles or liquid filled spaces within the cell the complexity of an essential molecular machine the hexameric transmembrane ring of the eukaryotic v atpase proton pump increased hundreds of millions of years ago we show that the ring of fungi which is composed of three paralogous proteins evolved from a more ancient two paralogue complex because of a gene duplication that was followed by loss in each daughter copy of specific interfaces by which it interacts with other ring proteins these losses were complementary so both copies became obligate components with restricted spatial roles in the complex reintroducing a single historical mutation from each paralogue lineage into the resurrected ancestral proteins is sufficient to recapitulate their asymmetric degeneration and trigger the requirement for the more elaborate three component ring our experiments show that increased complexity in an essential molecular machine evolved because of simple high probability evolutionary processes without the apparent evolution of novel functions they point to a plausible mechanism for the evolution of complexity in other multi paralogue protein complexes evolution of increased complexity in a molecular machine gregory c finnigan victor hanson smith tom h stevens joseph w thornton nature 2012 doi 10 1038 nature10724 i won t be able to give a detailed explanation until the description comes out from behind a paywall there s an explanation at nature blog and one at kurzweil look here for a diagram of v atpase this diagram shows the ancestral molecule in green and its more specialized descendents which need their increased complexity to properly assemble and function the ancestor is on the left evolution of v atpase protein chains share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in biology evolution science tags biochemistry molecular evolution peer reviewed research leave a comment symphony of science dna and genetics november 10 2011 monado this video is a hymn to learning about the role of dna in our lives it appears to be a subtle infomercial share this share on facebook opens in new window facebook share on x opens in new window x email a link to a friend opens in new window email print opens in new window print more share on reddit opens in new window reddit like loading posted in biology medicine science tags biochemistry dna genetics leave a comment older posts proudly powered by wordpress search for the out campaign atheism is a religion like not collecting stamps is a hobby penn jillette if atheism is a religion then bald is a hair color mark schnitzius if atheism is a religion then health is a disease clark adams archives archives select month march 2025 1 october 2023 1 june 2017 1 march 2017 1 december 2016 1 july 2016 1 november 2015 1 october 2015 1 february 2015 2 january 2015 5 december 2014 5 november 2014 1 october 2014 2 september 2014 1 august 2014 1 july 2014 2 june 2014 3 january 2014 3 december 2013 3 november 2013 3 october 2013 1 september 2013 1 august 2013 1 july 2013 1 june 2013 1 may 2013 1 april 2013 1 march 2013 1 february 2013 1 january 2013 2 december 2012 2 november 2012 3 october 2012 3 september 2012 6 august 2012 5 july 2012 4 june 2012 7 may 2012 7 april 2012 6 march 2012 7 february 2012 9 january 2012 17 december 2011 18 november 2011 10 october 2011 22 september 2011 12 august 2011 31 july 2011 13 june 2011 9 may 2011 6 april 2011 14 march 2011 15 february 2011 21 january 2011 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