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ongoing patients receiving treatment on the bezuclastinib combination arm the estimated mean duration of treatment for the bezuclastinib combination is projected to exceed 19 months cogent plans to present full results from the peak trial at a major medical meeting during the first half of 2026 additionally cogent is on track this quarter to initiate a phase 2 trial investigating the benefit of the bezuclastinib plus sunitinib combination for first line gist patients with exon 9 mutations who are naive to or recently initiated treatment with imatinib the nda submission with bezuclastinib in advanced systemic mastocytosis advsm also remains on track for the first half of 2026 bezuclastinib expanded access program working with the fda cogent has established active expanded access programs eaps for u s patients with gist or sm who meet disease specific criteria and could benefit from treatment with bezuclastinib or the combination of bezuclastinib and sunitinib a growing number of sites now offer access to the bezuclastinib eaps for more information please visit https www cogentbio com bezuclastinib program development our expanded access policy inducement grants under nasdaq listing rule 5635 c 4 cogent also announced today that on march 30 2026 the compensation committee of cogent s board of directors made up entirely of independent directors approved the grants of inducement equity awards to six new employees under the company s 2020 inducement plan with a grant date of march 30 2026 the awards were approved in accordance with listing rule 5635 c 4 of the corporate governance rules of the nasdaq stock market the employees received in the aggregate i nonqualified options to purchase 21 100 shares of cogent common stock and ii 15 700 restricted stock units rsus each option has a 10 year term an exercise price equal to the closing price of cogent s common stock on the grant date and a 4 year vesting schedule with 25 vesting on the 1 year anniversary of the grant date and the remainder vesting in equal monthly installments over the subsequent 36 months provided such employee remains employed through each such vesting date the rsus vest annually in equal installments over 4 years from the grant date provided such employee remains employed through each such vesting date https en wikipedia org wiki bezuclastinib read more posted by https www med chemist com at 2 56 pm labels for bezuclastinib gastrointestinal in new drug application stromal tumors gist submission thursday july 30 2026 nanomedicine offers targeted solutions for breast cancer treatment breast cancer bca is one of the most common cancers worldwide with high mortality and morbidity in women this review focuses on the applications of nanotechnology nanomaterials nms and nanoparticles nps in bca diagnosis and therapy nanotechnologies nanocarriers and nano encapsulation versus conventional counterparts are discussed various drug formulations into lipid nps nanoemulsions polymeric nps and metal based nps enhance bioavailability and therapeutic efficacy overcoming limitations of conventional formulations clinical specialists have achieved improved outcomes in bca detection and monitoring using nanotechnology ultimately improving patients quality of life introduction cancer is a leading cause of death globally breast cancer accounts for 30 of all cancer cases and 15 of cancer related deaths in women the pi3k akt mtor signaling pathway plays a crucial role in bca development and progression nanomedicine applies nms and nps for prevention diagnosis and treatment this review addresses challenges of conventional therapies lack of target specificity drug resistance systemic toxicity and highlights how nanotechnology overcomes these limitations general aspects of nms and nps nms have at least one dimension in 1 100 nm and a large surface to volume ratio conferring novel properties reducing particle size increases solubility and surface interactions nanotechnology improves pharmacokinetics enables targeted delivery enhances permeability and retention effects in tumors and reduces required drug doses different aspects of bca statistics globocan 2022 reported 2 296 840 new bca cases asir 46 8 per 10 and 666 103 deaths asmr 12 7 per 10 worldwide molecular subtypes bca is classified by hormone receptor and her2 status luminal a 40 er pr her2 luminal b 20 er pr her2 her2 enriched 10 15 er pr her2 and triple negative breast cancer tnbca 15 20 er pr her2 tnbca is aggressive occurs in younger women has high recurrence and metastasis rates and lacks targetable proteins challenges treatment resistance recurrence adverse effects low cellular absorption and multidrug resistance therapies surgery chemotherapy radiotherapy hormonal therapy and immunotherapy nanotechnology offers innovative carriers to overcome limitations carriers and nanocarriers for drug delivery conventional carriers have limited tumor response and affect normal cells nanocarriers include lipid nanoparticles lnps nanoemulsions nes polymeric nms and metallic nps they enhance drug stability absorption encapsulation efficiency bioavailability and controlled release nes improve oral delivery of poorly soluble drugs and reduce toxicity nanocarriers for bca chitosan based nanocarriers exploit electrostatic interactions with cancer cells enhance cellular uptake and open tight junctions quaternary ammonium chitosan improves penetration chitosan nps deliver genes drugs and natural compounds induce phototherapy mediated tumor ablation and support combination therapy clinical results nanocarriers improved drug delivery and outcomes photothermal nanomaterials ptt with nanotechnology enhanced metastatic bca treatment reduced damage to healthy cells and synergized with chemotherapy immunotherapy cyclophosphamide nes in rats showed remarkable tumor reduction exemestane loaded polymer lipid hybrid nanoparticles plh nps improved oral bioavailability 3 5 fold and tumor inhibition 62 vs 31 for conventional suspension in mice major metallic nanocarriers gold au nps biocompatible easy surface modification effective against tnbca via rad6 conjugation inducing mitochondrial dysfunction clinical translation limited by toxicity in liver kidneys spleen silver ag nps high photon attenuation ethyl cellulose coated ag nps inhibited tnf α in bca cells copper cu nps bioactive 5 fluorouracil loaded into β cyclodextrin cu nps showed sustained release and anticancer activity against tnbca iron oxide fe o nps magnetic core shell nps fe o poly n isopropylacrylamide grafted chitosan delivered methotrexate with 94 entrapment efficiency enhanced antitumor activity against mcf 7 cells at 40 c and ph 5 5 ref https www xiahepublishing com 2996 3427 ona 2025 00027 read more posted by https www med chemist com at 10 16 am labels breast cancer nanomedicine offers targeted solutions treatment wednesday july 29 2026 metformin mimics exercise related metabolic effects in prostate cancer patients in continuation of my update on metformin a new study has found that metformin a widely prescribed diabetes drug may mimic one of exercise s core biological effects in men with prostate cancer raising levels of a molecule tied to energy balance and weight control even when patients are inactive the findings suggest metformin could help counter the metabolic strain of hormone therapy when fatigue and other side effects often limit physical activity led by physician scientists at sylvester comprehensive cancer center part of the university of miami miller school of medicine the study appears in the journal embo molecular medicine exercise is one of the most reliable ways to support health during cancer treatment it helps regulate weight blood sugar and cardiovascular health factors that shape how patients feel during therapy and how well they recover afterward for many people with cancer however regular exercise isn t always feasible fatigue hormone therapy pain or advanced disease can limit physical activity precisely when metabolic health becomes most important that reality has led researchers to ask a practical question if exercise confers its benefits through specific biological signals could some of those signals be activated in other ways according to the research the answer may be yes sylvester investigators report that metformin raises levels of a naturally occurring molecule involved in how the body manages energy and weight in prostate cancer patients the finding does not suggest that a pill can replace physical activity instead it offers insight into the internal pathways that underlie exercise s metabolic benefits and how those pathways might still be engaged when movement is limited this study reflects what s possible when laboratory science metabolic biology and clinical investigation are intentionally brought together for transdisciplinary studies by working across sylvester s tumor biology cancer epigenetics and translational clinical oncology programs we were able to link a well defined molecular signal to real patient data the result isn t a new cancer biomarker but a clearer understanding of how a widely used drug may support metabolic health during prostate cancer treatment an outcome that matters to patients and clinicians alike marijo bilusic m d ph d sylvester researcher and first author genitourinary medical oncologist and professor of medicine and medical oncology at the miller school at the center of the collaborative team science study is a molecule called n lactoyl phenylalanine or lac phe while its name is technical its role is relatively simple lac phe is produced when the body is under metabolic demand it forms when lactate a substance that accumulates during exertion combines with phenylalanine a basic building block of protein scientists first took notice of lac phe because its levels spike after intense exercise coinciding with shifts in energy use and appetite regulation https en wikipedia org wiki metformin metformin mimics exercise related metabolic effects in prostate cancer patients posted by https www med chemist com at 1 20 pm labels exercise related in prostate cancer patients metabolic effects metformin mimics tuesday july 28 2026 fda approves komzifti ziftomenib for the treatment of adults with relapsed or refractory npm1 mutated acute myeloid leukemia kura oncology inc nasdaq kura and kyowa kirin co ltd tse 4151 announced the u s food and drug administration fda approval of komzifti ziftomenib for adult patients with relapsed or refractory r r acute myeloid leukemia aml with a susceptible npm1 mutation who have no satisfactory alternative treatment options komzifti is the first and only once daily oral menin inhibitor approved for r r npm1 mutated npm1 m aml a devastating blood cancer with limited treatment options komzifti combines compelling efficacy a favorable safety profile compatibility with concomitant medications and convenient once daily oral administration in a population with few effective treatment options these features highlight komzifti s potential to serve as the menin inhibitor of choice in its approved indication said troy wilson ph d j d president and chief executive officer of kura oncology together with our partner kyowa kirin we remain committed to advancing development of komzifti across the treatment continuum for aml where its best in class profile offers potential for even greater impact in combination regimens and earlier lines of therapy we are fully prepared to launch komzifti today and deliver this new medicine to patients in need npm1 mutations are among the most common founder mutations in aml occurring in approximately 30 of cases historically approximately 20 of patients with npm1 m aml do not respond to front line therapy of those who do respond 70 will relapse within 3 years most within 12 months early relapse and declining survival with each recurrence underscore the urgent need for treatment approaches that deliver lasting remission approval is supported by the pivotal komet 001 trial nct04067336 which evaluated komzifti s safety and efficacy in 112 r r npm1 m aml patients the rate of complete remission cr plus cr with partial hematologic recovery crh was 21 4 95 ci 14 2 30 2 the median duration of cr crh was 5 0 months 95 ci 1 9 8 1 and the median time to first response in patients who achieved a cr or crh was 2 7 months range 0 9 to 15 months 88 of patients who achieved cr or crh did so within 6 months of initiating komzifti these data from the prescribing information are generally consistent with findings recently published in the journal of clinical oncology 1 komzifti addresses a critical need for adult patients with r r npm1 m aml many of whom are older and unable to tolerate intensive chemotherapy or transplant said eunice wang m d chief of the leukemia service and professor of oncology at roswell park comprehensive cancer center the clinical data demonstrate deep and durable responses with a manageable safety profile including no drug drug interactions and no boxed warnings for qtc prolongation or torsades de pointes key advantages for patients on multiple concurrent medications this approval equips physicians with a new oral therapy to integrate into care and improve outcomes for this vulnerable patient population the most common adverse reactions 20 including laboratory abnormalities were aspartate aminotransferase increased infection without an identified pathogen potassium decreased albumin decreased alanine aminotransferase increased sodium decreased creatinine increased alkaline phosphatase increased hemorrhage diarrhea nausea fatigue edema bacterial infection musculoskeletal pain bilirubin increased potassium increased differentiation syndrome pruritus febrile neutropenia and transaminases increased komzifti includes a boxed warning for differentiation syndrome a well studied mechanism based risk in drugs that restore differentiation absence of clinically meaningful drug drug interactions can ease the use of komzifti with concomitant therapies including those that cause qtc interval prolongation qtc interval prolongation was grade 3 in 12 of patients and no grade 4 or grade 5 qtc interval prolongation was reported qtc interval prolongation of any cause occurred in 10 of the 70 patients 65 years of age or older the approval of komzifti underscores our commitment to advancing precision medicines to address the genetic drivers of disease in hematology and oncology said takeyoshi yamashita ph d executive vice president and chief medical officer of kyowa kirin in aml where many patients face severe disease progression and limited treatment options the evolution toward targeted therapies such as komzifti represents a major step forward and offers potential to transform existing standards of care we are proud to partner with kura oncology in bringing this important therapy to patients and their families in november 2024 kura oncology and kyowa kirin entered into a global strategi...