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description=Epidemiological studies suggest that soyfood and isoflavones may reduce breast cancer risk and may have beneficial effect on breast cancer survivors.;

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effect of isoflavones on breast cancer skip to content isoflavones menu home what are isoflavones how do isoflavones work metabolism women s health menopause menopausal symptoms hot flushes breast tenderness heart disease depression anxiety incontinence insomnia cancer risk osteoporosis treatment of menopausal symptoms list of menopausal symptoms estrogen emea public statement regarding hormone replacement therapy men s health other benefits isoflavones are antioxidants vascular protection bone health anti cancer breast cancer prostate cancer endometrial cancer other cancers brain health safety sources soy red clover supplements isoflavones content news references breast cancer human studies indicate that the intake of soy reduces the risk of breast cancers but are isoflavones healthy or risky for breast cancer patients and survivors many studies have demonstrated the anticancer properties of soy isoflavones but its estrogen like effect and conflicting data from in vivo and in vitro studies have raised concern about isoflavones intake and the promotion or propagation of estrogen sensitive cancers some health professionals still remain confused and even recommend that breast cancer survivors should not consume soy or isoflavones supplements in vitro and animal studies a review of in vitro studies found that low levels of isoflavones promote the growth of estrogen sensitive breast cancer cells but inhibit cell growth at higher levels 1 many in vitro studies that showed genotoxic effects of genistein have used genistein in high doses that cannot be obtained in humans by intake of natural dietary products however imhof found that low levels of isoflavones inhibited the growth of breast cancer cells when they were co incubated with low levels of estradiol which are even present in postmenopausal women 2 imhof concluded that his findings emphasized the reported advantageous properties of isoflavones for postmenopausal women a recent study by liu and co workers at the state university of new york concluded that daidzein and its metabolite equol inhibited the growth of mammary tumors in rodents the scientists were optimistic that daidzein or equol could be used in new drugs for treating breast cancer they also suggested that the consumption of daidzein may protect against breast cancer 7 human studies according to a review by taylor et al asian epidemiological studies attribute reduced incidence of breast and prostate cancers to soy food and isoflavones consumption 3 concerns are mainly based on in vitro and animal studies which suggest that genistein can stimulate tumor cell proliferation and growth in mice having deficient immune systems but recent case control study and epidemiological studies show an inverse correlation between genistein intake and breast cancer risk clinical studies on postmenopausal women confirm the breast and uterine safety of pure genistein administered for up to 3 years a recent population based cohort study that attracted worldwide attention concluded that among women with breast cancer soy food consumption was significantly associated with decreased risk of death and recurrence 4 shu and co workers found that women with the highest intake of soy protein 15 g soy protein per day had a 29 percent lower risk of death and 32 per cent lower risk of breast cancer recurrence compared to patients with the lowest intake 5 3 g soy protein per day this inverse relationship was evident among women with both estrogen receptor positive and estrogen receptor negative breast cancer the association of soy isoflavones with mortality and breast cancer recurrence followed a dose dependent pattern until soy isoflavones intake reached 40 mg per day after which the association appears to level or even rebound they suggest that soy isoflavones protects against breast cancer by competing with estrogens in the binding of estrogen receptor a recent study found that intake of isoflavones was associated with lower risk of recurrence among postmenopausal patients with breast cancer positive for estrogen and progesterone receptor and those patients who received anastrozole as endocrine therapy 5 an article published in cancer recommends that women should consume soy foods because of its health benefits 8 soy foods not only prevent breast cancer but also benefit women who have already have breast cancer effect of isoflavones on tamoxifen in some experimental studies the inhibitory effect of tamoxifen drug that is commonly used to prevent recurrence and prolonging survival on the growth of implanted mammary tumors were negated by the administration of isoflavones but other studies showed that isoflavones caused a synergistic effect on the growth inhibition by tamoxifen one study that raised concern about the safety of genistein was an experiment with rodents carried about by helferich and co workers 6 they implanted estrogen dependent tumours into ovariectomized mice and found that dietary genistein was able to negate the inhibitory effect of tamoxifen on tumour growth most importantly epidemiological data showed that soyfood intake by breast cancer patients was associated with improved survival also for women who took the anti cancer drug tamoxifen 4 these results indicate that isoflavones do not reduce the efficacy of tamoxifen isoflavones supplements and breast cancer risk most human studies that demonstrated the protective effect of isoflavones looked at the intake of soy foods and not isoflavones supplements not enough studies have been done to determine whether or not high concentrations of isoflavones may encourage the growth of breast cancer if you re taking soy supplements to treat menopausal symptoms speak with your health professional about quantity of isoflavones that may be safe for you conclusion epidemiological studies suggest that soyfood and isoflavones may reduce breast cancer risk and may have beneficial effect on breast cancer survivors however it cannot be ruled out that isoflavones could promote breast cancer in postmenopausal women intake of high levels of purified isoflavones by these women is not without risk references 1 klein et al genistein genotoxicity critical considerations of in vitro exposure dose toxicol appl pharmacol 2007 oct 1 224 1 1 11 2 imhof et al effects of soy isoflavones on 17beta estradiol induced proliferation of mcf 7 breast cancer cells 3 taylor et al the effect of genistein aglycone on cancer and cancer risk a review of in vitro preclinical and clinical studies nutr rev 2009 jul 67 7 398 415 4 shu et al soy food intake and breast cancer survival jama 2009 dec 9 302 22 2437 43 5 kang et al effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy cmaj 2010 oct 18 6 helferich et al phytoestrogens and breast cancer a complex story inflammopharmacology 2008 oct 16 5 219 26 7 liu x et al anti breast cancer potential of daidzein in rodents life science 2012 oct 5 91 11 12 415 9 8 o kucuk soy foods isoflavones and breast cancer cancer 06 march 2017 privacy policy disclaimer proudly powered by wordpress this website uses cookies to improve your experience we ll assume you re ok with this but you can opt out if you wish accept reject read more privacy cookies policy close privacy overview this website uses cookies to improve your experience while you navigate through the website out of these the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website we also use third party cookies that help us analyze and understand how you use this website these cookies will be stored in your browser only with your consent you also have the option to opt out of these cookies but opting out of some of these cookies may affect your browsing experience necessary necessary always enabled necessary cookies are absolutely essential for the website to function properly this category 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