Meta tags:
description= ;
keywords=;

Headings (most frequently used words):

research, focus, current, projects, collaborations,

Text of the page (most frequently used words):
and (135), the (129), #research (94), for (47), publications (44), team (42), center (39), about (36), synaptic (31), news (29), medicine (29), funding (27), uke (26), with (24), training (23), groups (22), contact (20), information (19), group (19), are (18), teaching (18), medical (17), care (17), development (16), plasticity (16), management (15), patient (15), department (15), that (14), working (14), clinic (14), services (14), hamburg (13), microglia (12), synapses (12), neuronal (11), tools (11), these (11), this (11), can (11), signaling (11), history (11), health (11), international (10), role (10), function (10), neurons (10), brain (10), project (10), using (10), institute (10), university (10), clinical (10), professional (10), data (9), camp (9), dendritic (9), spines (9), events (9), changes (9), systems (9), neuroscience (9), outpatient (9), trials (9), external (9), donation (8), optogenetic (8), stroke (8), from (8), molecular (8), intracellular (8), curriculum (8), studies (8), press (7), investigate (7), activity (7), have (7), experimental (7), process (7), cell (7), treatment (7), cyclic (7), hospital (7), board (7), biology (7), education (7), surgery (7), cancer (7), media (6), quality (6), collaborate (6), after (6), how (6), not (6), over (6), microscopy (6), processing (6), calcium (6), known (6), long (6), term (6), projects (6), institutes (6), oncology (6), general (6), alliances (6), physicians (6), eppendorf (5), career (5), recovery (5), develop (5), genetically (5), ensembles (5), which (5), interested (5), cells (5), only (5), our (5), protein (5), structural (5), light (5), cellular (5), strength (5), network (5), faculty (5), centers (5), partners (5), referring (5), options (5), pediatric (5), phd (5), system (4), 7410 (4), your (4), life (4), patients (4), map (4), emergency (4), service (4), german (4), login (4), zmnh (4), encoded (4), between (4), during (4), particular (4), focus (4), high (4), active (4), time (4), been (4), their (4), temporal (4), mice (4), several (4), days (4), learning (4), affects (4), lab (4), image (4), also (4), involved (4), 2020 (4), release (4), while (4), its (4), effects (4), electron (4), activated (4), microglial (4), connections (4), second (4), cgmp (4), such (4), study (4), departments (4), facility (4), overview (4), affairs (4), core (4), neural (4), technology (4), tumor (4), students (4), continuing (4), facts (4), figures (4), program (4), applying (4), important (3), blood (3), transport (3), building (3), room (3), security (3), behavioral (3), optical (3), stimulation (3), communication (3), occur (3), when (3), animals (3), memory (3), experience (3), mouse (3), hippocampus (3), but (3), use (3), dynamics (3), spatial (3), circuit (3), two (3), photon (3), large (3), 2021 (3), perez (3), alvarez (3), environment (3), aim (3), well (3), has (3), previously (3), further (3), functional (3), storage (3), studying (3), interest (3), based (3), ltp (3), networks (3), spine (3), they (3), pathways (3), dfg (3), central (3), years (3), constantin (3), amp (3), resolution (3), adenylyl (3), cyclases (3), pacmn (3), thought (3), specific (3), messenger (3), understand (3), other (3), gmbh (3), nursing (3), social (3), library (3), office (3), hygiene (3), safety (3), signal (3), transduction (3), biochemistry (3), crc (3), immunology (3), psychiatry (3), psychotherapy (3), multiple (3), sclerosis (3), members (3), epidemiological (3), epidemiology (3), interdisciplinary (3), routine (3), dentistry (3), intensive (3), stay (3), admissions (3), nuclear (3), radiology (3), facilities (3), programs (3), survivorship (3), tumors (3), advising (3), universitätsklinikum (2), knowledge (2), through (2), competence (2), code (2), into (2), hamburger (2), public (2), main (2), o10 (2), location (2), directions (2), pathfinder (2), christian (2), georg (2), nagel (2), peter (2), hegemann (2), gao (2), tim (2), magnus (2), experiments (2), sensors (2), novel (2), beck (2), patterns (2), subset (2), memories (2), space (2), associated (2), understanding (2), number (2), inside (2), why (2), pre (2), structure (2), identify (2), exclusively (2), express (2), expressed (2), learn (2), water (2), task (2), monitor (2), chemogenetic (2), funded (2), hippocampal (2), major (2), establishing (2), software (2), repertoire (2), results (2), often (2), useful (2), model (2), analysis (2), glutamate (2), acquisition (2), neuron (2), concentration (2), endoplasmic (2), reticulum (2), present (2), some (2), synthesis (2), ability (2), shown (2), dynamic (2), efficacy (2), called (2), particularly (2), ultrastructural (2), manipulating (2), non (2), level (2), formation (2), different (2), timescales (2), interaction (2), mechanisms (2), collaboration (2), marie (2), charlotte (2), oldenburg (2), period (2), control (2), impact (2), designer (2), drugs (2), stimulate (2), processes (2), affected (2), area (2), response (2), one (2), oana (2), all (2), dependent (2), developed (2), established (2), nucleotide (2), goal (2), nucleotides (2), alterations (2), photoactivatable (2), 2015 (2), receptors (2), cascades (2), downstream (2), developing (2), new (2), scheib (2), 2018 (2), key (2), methods (2), identified (2), measure (2), postsynaptic (2), allows (2), individual (2), connectivity (2), rules (2), guide (2), heart (2), medigate (2), forex (2), reports (2), catering (2), altona (2), children (2), healthcare (2), specialists (2), academy (2), staff (2), printing (2), support (2), translation (2), ethics (2), areas (2), internal (2), human (2), organization (2), abroad (2), head (2), council (2), vice (2), deanery (2), trustees (2), pathology (2), neuro (2), neurobiology (2), physiology (2), open (2), exchange (2), advocacy (2), elbs (2), offer (2), home (2), erc (2), rare (2), occupational (2), sfbs (2), section (2), neuroimmunology (2), body (2), neurogenetics (2), job (2), candidates (2), leibniz (2), organelles (2), cooperations (2), dermatology (2), pharmacology (2), toxicology (2), cardiovascular (2), decipher (2), applied (2), morphology (2), orthopedics (2), transplantation (2), cardiology (2), pediatrics (2), oral (2), doctoral (2), obstetrics (2), diagnostic (2), interventional (2), endoscopy (2), visceral (2), colon (2), anesthesiology (2), prevention (2), psychosocial (2), ucch (2), palliative (2), sciences (2), transgenic (2), science (2), conferral (2), habilitation (2), campus (2), promotion (2), opportunities (2), family (2), degree (2), admission (2), imprint, protection, sitemap, healing, shared, certification, company, martinistrasse, 20246, please, enter, postal, 20251, navigation, callcenter, info, honorary, position, sparkasse, iban, 54200505501234363636, bic, haspdehhxxx, beneficiary, donate, online, zukunftsplan, 2050, hoou, gesundheitsakademie, videos, arrival, airport, stadtrad, verkehrsverbund, hvv, 24h, kinder, o47, 55555, auf, einen, blick, last, update, 2026, bookmark, recommend, print, astrocytic, lohr, tool, shiqiang, phase, performed, matthias, kneussel, fabio, morellini, wedel, devices, rapp, optoelectronics, london, fast, katalin, török, berlin, würzburg, nyc, nils, brose, antoine, triller, anne, schäfer, collaborations, andreas, franzelin, lennart, encoding, then, reactivated, revisit, was, conditioned, stimulus, presented, emerge, vast, others, there, physiological, signature, selects, them, dentate, gyrus, extremely, density, few, given, fundamental, episodic, serves, discriminator, similar, experiences, lines, engineered, tag, allow, manipulation, chosen, window, challenge, escape, tank, morris, maze, take, master, combining, selective, tagging, opto, interrogate, needed, solve, integrated, sfb936, representations, schulze, analytical, technique, used, easily, produces, amounts, workflows, both, commercial, custom, matlab, python, quantitative, extracted, acquired, images, reproducible, way, laprell, modifying, instrument, add, common, features, interpret, test, intuition, biophysically, realistic, contributed, vesicular, simulating, event, monte, carlo, simulation, mcell, dürst, automatizing, kelsey, zingg, conditions, under, acts, source, sink, complex, organelle, distributed, throughout, including, soma, axon, arbor, less, stably, visited, transient, every, consequences, nat, commun, ip3r, mediated, dramatic, holbro, pnas, 2009, rui, wang, represent, mechanism, importantly, electrochemical, mechanical, nature, aspect, distinguish, read, out, reveal, material, basis, generate, synapse, optogenetically, followed, microscope, imaging, manipulated, purpose, peroxidase, genetic, tags, hrp, apex2, etc, correlative, clem, combined, sparse, transfection, invasive, strategies, establish, readout, ultrastructure, kristina, ponimaskine, elimination, play, remodeling, highly, occurs, get, better, nearby, excitatory, inhibitory, extended, periods, organotypic, slice, cultures, removal, appearance, any, repercussions, local, neighborhood, shaped, homeostatic, neighboring, competition, luise, brehme, lost, motor, slowly, regained, weeks, involves, whether, helps, hinders, modified, asses, supported, spp, 2395, dreadd, receptor, creert2, cno, effect, outcome, commonly, referred, immune, nervous, post, migrate, where, clear, debris, drive, strong, neuroinflammatory, affect, highest, causes, death, disability, world, wide, despite, many, searching, neuroprotective, therapies, perfusion, remains, effective, interactions, carolina, pinto, most, molecules, increase, decrease, governs, functions, ancient, molecule, found, organisms, kingdoms, bacteria, plants, modulate, possible, traditional, pharmacological, approaches, improved, carhac, selectively, tightly, levels, strengthen, consolidation, newly, unravel, enzymes, expanding, toolbox, manipulations, line, blue, elevated, specifically, spatio, enables, investigation, properties, eileen, wiesenhavern, elucidate, correlate, potentiation, roles, still, unclear, especially, much, becyclop, patch, clamp, recordings, assess, types, christine, gee, would, like, store, towards, reaching, method, induce, spike, timing, small, ca3, ca1, follow, anisimova, very, modulation, coupled, bypass, characterizing, rhodopsin, guanylyl, membrane, anchored, dark, cyclase, syntagma, potassium, channel, become, quite, modulating, revealed, unexpected, inter, spiking, hard, work, currently, landesforschungsförderung, 2419, sfb, 1328, regulating, current, optically, amplitude, transients, laser, scanning, perform, optophysiological, intact, tissue, probes, single, hundred, stimulations, parameters, potency, probability, induction, underlying, electrical, biochemical, great, detail, constantly, sensory, huber, 2012, govern, extraordinary, remember, communicate, chemical, depending, channels, rapidly, persistently, change, adaptations, collectively, involve, longer, unconnected, completely, removed, together, circuits, crucial, top, page, homepage, search, martini, klinik, janssen, haus, psychiatric, gutachten, experts, llc, logistics, mvz, subsidiaries, personnel, pool, counselling, physiotherapy, pharmacy, amboss, imed, textbook, video, tutorials, mephisto, moodle, elearning, help, suggestion, interpreter, bed, occupancy, purchasing, legal, auditing, resources, fundraising, sponsoring, communications, relations, controlling, case, business, divisions, hc3r, what, does, mean, voxel, man, organizational, wiring, emeritus, acknowledgment, grants, positions, hub, computation, regulatory, ctdna, ctc, dissemination, assembly, downloads, member, membership, patronages, conferences, symposia, meetings, activities, industry, academic, goals, european, liquid, biopsy, society, transfusion, neuroscientific, mri, sex, forensic, psychosomatic, national, bone, special, rtg, 3144, interfaces, cru, 5029, probone, deseases, osteology, biomechanics, ercs, computational, cognitive, neurophysiology, pathophysiology, donations, neuropathology, neuroanatomy, employees, reasearch, psychology, sociology, microbiology, virology, courses, disciplines, interests, cooperation, statistical, methodological, dates, biometry, 1648, meister, infection, vaccine, genetics, plan, visit, museum, professorship, economics, practice, primary, openings, excellence, apply, here, equipment, secondary, integration, kip, ipmi, agile, asd, aai, informatics, kohler, rathod, schinner, spindler, anatomy, voice, speech, hearing, disorders, vascular, urology, divison, trauma, stem, laboratory, radiobiology, radiooncology, radiotherapy, radiation, prosthetic, preventive, restorative, plastic, reconstructive, aesthetic, hematology, neonatology, otolaryngology, orthodontics, maxillofacial, ophthalmology, clerks, rotation, specialist, polyclinic, fetal, neurosurgery, neuroradiology, neurology, iii, cardiac, arrest, ucach, gynecology, thoracic, venereology, child, adolescent, centre, transplant, perinatal, registration, boards, oncological, medicolegal, aspects, registry, documentation, helpful, carreer, course, fellows, calls, mildred, scheel, nachwuchszentrum, school, biobank, young, adults, caya, side, lifestyle, early, detection, aftercare, personalized, supportive, opinion, therapy, sarcoma, liver, metastases, complementary, hereditary, gastrointestinal, gesundheitskiosk, hospitals, advisory, organ, chart, hubertus, wald, athleticum, athletic, martin, zeitz, diseases, addiction, childhood, adolescence, breast, wards, surgical, details, proteostasis, guest, fraunhofer, itmp, rna, pathomechanisms, rehabilitative, unit, developmental, bioinformatics, neurocenter, diagnostics, dental, equality, commissioner, transfer, liaison, officer, ombudsperson, scholarship, äzb, infrastructure, biomedical, equal, women, fundings, state, bmbf, units, collaborative, voluntary, year, scientists, covid, faqs, partner, universities, semester, electives, degrees, midwifery, application, spectrum, merchandising, culinary, delights, shopping, certifications, risk, appraisal, complaint, satisfaction, survey, spiritual, welfare, visiting, fears, concerns, dialog, orientation, house, discharge, rights, optional, choices, daily, preparation, visitors, privacy, statement, guests, 125, impressions, wissen, forschen, publication, annual, review, magazine, releases, musik, mensch, medizin, strategy, growth, executive, menü,

Text of the page (random words):
groups external funding and cooperations crc 1648 publications leibniz group dendritic organelles and synaptic function team research funding publications medical biometry and epidemiology news team events dates research statistical methodological research epidemiological research clinical research health care research publications we offer for uke members for interests in cooperation for uke students for students other disciplines for job candidates for press teaching training courses history contact medical microbiology virology and hygiene team research working groups research alliances publications medical systems biology news team research funding publications teaching training medical sociology team research publications medical psychology news team research reasearch groups research alliances publications treatment options services curriculum professional development students employees history molecular neurogenetics news team research funding publications teaching training neuroanatomy news team research publications services curriculum professional development history body donation neuroimmunology and multiple sclerosis news team research publications funding neuropathology team research working groups publications history donations neurophysiology and pathophysiology team research section network neuroscience section computational cognitive neuroscience research groups external funding sfbs ercs publications teaching training occupational medicine news team research research groups external funding publications history contact osteology and biomechanics team research working groups research alliances cell biology of rare deseases cru 5029 probone home publications contact rtg 3144 interfaces national bone board special outpatient health care center psychosomatic medicine and psychotherapy information for referring physicians sex research and forensic psychiatry structural and systems biology news team research publications curriculum professional development institute for synaptic neuroscience news team research funding publications teaching training systems neuroscience team neuroscientific mri research research training groups research groups external funding research alliances publications curriculum professional development history systems immunology news team research funding publications teaching training transfusion medicine blood donation tumor biology news team research working groups external funding crc erc research alliances studies trials publications information for patients curriculum professional development history european liquid biopsy society elbs home about us goals we are we offer working groups network academic partners industry partners patient advocacy partners activities projects meetings lb clinical trials publications news events conferences symposia patronages press donation membership login member elbs downloads general assembly wg dissemination education wg clinical wg technology ctc wg technology ctdna wg technology ev wg regulatory wg data computation wg patient advocacy exchange hub open positions projects and grants general contact acknowledgment research group neural circuit physiology news team research funding publications teaching and training zmnh core facility behavioral biology news team research funding publications teaching training emeritus group cell biochemistry and clinical neurobiology research group neuronal development news team research funding publications teaching training research group neuronal protein transport research group neuronal and cellular signal transduction news team research funding publications teaching training research group molecular pathology in neuro oncology news team research funding publications teaching and training research group synaptic wiring and information processing news team research funding publications teaching training organizational structure the board board of trustees faculty of medicine our faculty of medicine vice deanery for research vice deanery for teaching medical library medigate gmbh voxel man team publications hamburg center of 3r research 3r what does this mean 3r board 3r research hc3r research funding news contact council centers patient and care management head office nursing staff from abroad business divisions case management about us controlling communications and public relations about us services overview contact developing department fundraising and sponsoring human resources and organization services overview career contact internal auditing about us it legal affairs about us services overview project management contact purchasing quality management and patient safety safety security and environment about us central areas bed occupancy management uke clinical ethics hospital hygiene international office international patients process interpreter translation services contact medical library about us media acquisition suggestion help support elearning mephisto moodle video tutorials imed textbook amboss contact or management pharmacy about us 3d printing of drugs physiotherapy about us social and care counselling staff and faculty health services university academy personnel and pool management for nursing and healthcare specialists subsidiaries the altona children s hospital health care center mvz at the altona children s hospital clinic catering eppendorf facility management clinic logistics eppendorf clinic services eppendorf services overview forex gutachten gmbh forex medical experts reports llc janssen haus psychiatric outpatient clinic martini klinik medigate gmbh contact outpatient center university heart center facility management emergency blood donation guide contact search homepage departments institutes institutes institute for synaptic neuroscience research research zmnh institute for synaptic neuroscience news team research funding publications teaching training top of page research focus neurons in the brain communicate through chemical synapses depending on the activity of pre and postsynaptic cells these communication channels can rapidly and persistently change their strength these functional adaptations collectively known as long term plasticity involve a large number of intracellular signaling systems on longer timescales new synapses are established between previously unconnected cells while other synaptic connections are completely removed together these changes in the efficacy and connectivity of brain circuits are thought to be crucial for information processing and memory storage in the brain we develop optogenetic methods to stimulate identified neurons and to optically measure the amplitude of postsynaptic calcium transients in dendritic spines two photon laser scanning microscopy allows us to perform such optophysiological experiments in intact brain tissue with high spatial and temporal resolution using genetically encoded probes we monitor the activity of single synapses over several hundred stimulations and measure parameters such as synaptic potency and the probability of glutamate release optical induction of plasticity at individual identified synapses allows us to investigate the underlying electrical and biochemical processes in great detail the connectivity of our brain constantly changes in response to sensory experience huber et al 2012 a central aim of our research is to understand the rules and molecular mechanisms that govern our extraordinary ability to learn and to remember current projects second messenger systems regulating synaptic plasticity i would like to understand how networks of neurons and their synaptic connections store information towards reaching this goal we have developed an all optical method to induce spike timing dependent plasticity at a small subset of hippocampal ca3 ca1 connections so that we can follow the changes in synaptic strength over days anisimova et al 2021 i also am very interested in modulation of synaptic strength by g protein coupled receptors and intracellular signaling cascades downstream of camp and cgmp to bypass the receptors and study the intracellular cascades in particular cells i have been involved in developing and characterizing new optogenetic tools such as the rhodopsin guanylyl and adenylyl cyclases scheib et al 2015 scheib et al 2018 and a membrane anchored no dark activity photoactivatable adenylyl cyclase called pacmn constantin et al 2021 syntagma perez alvarez et al 2020 and a light activated potassium channel beck et al 2018 are other tools that have become quite useful for studying and modulating network activity using some of these optogenetic tools has revealed a key role of unexpected inter cellular communication pathways downstream of camp or neuronal spiking that we are working hard to understand my work is currently funded by the landesforschungsförderung hamburg and the dfg for 2419 and sfb 1328 christine gee role of cyclic nucleotides in synaptic function the goal of my project is to elucidate the role of cyclic nucleotides camp and cgmp in synaptic function alterations in synaptic strength are thought to be the cellular correlate of learning these alterations can occur during long term potentiation in which the roles of camp and cgmp are still unclear especially in the hippocampus not much is known of the cell specific role of cgmp in synaptic function i am using genetically encoded sensors and photoactivatable cyclases such as becyclop gao et al 2015 as well as patch clamp recordings to assess cyclic nucleotide dynamics and their impact on synaptic strength in different cell types marie eileen wiesenhavern second messenger signaling in microglia while the role of microglial second messenger signaling in learning and memory is established the focus has been on the effects of intracellular calcium in my project i am expanding the toolbox for optogenetic manipulations of microglia by the development of a microglia specific pacmn mouse line using blue light as stimulation intracellular camp can be elevated specifically in microglia with high spatio temporal resolution this development enables the investigation of microglial cyclic nucleotide signaling and its effects on microglial properties as well as on microglia neuron interaction oana constantin development of optogenetic enzymes cyclic amp is one of the most important intracellular signaling molecules its increase and decrease governs a large repertoire of cellular functions it is an ancient molecule that can be found in organisms from all kingdoms of life from bacteria to plants and animals we develop tools to modulate the intracellular concentration of camp with high spatial and temporal resolution which is not possible with traditional pharmacological approaches improved light activated adenylyl cyclases carhac pacmn can be selectively expressed in the cells of interest and activated with light to tightly control intracellular camp levels in the brain cyclic amp is thought to be involved in learning when changes occur in the environment the connections between specific neurons strengthen a process known as long term plasticity or ltp cyclic amp signaling pathways are active during the consolidation of ltp a process that is dependent on protein synthesis and structural changes at synapses i am using the newly developed optogenetic tools to unravel the function of camp signaling in the hippocampus during long term plasticity oana constantin carolina pinto interactions of microglia and neurons after stroke stroke is one of the highest causes of death and disability world wide despite many years searching for neuroprotective therapies re establishing perfusion to the affected area remains the only effective treatment microglia commonly referred to as the immune cell of the central nervous system are involved in post stroke processes they migrate into the affected area where they clear debris and drive a strong neuroinflammatory response we are interested in if manipulating microglial function can affect recovery after stroke we express a gq dreadd designer receptor exclusively activated by designer drugs only in microglia using the creert2 system and stimulate gq signaling with cno and investigate the effect on stroke outcome charlotte oldenburg the role of microglia in the recovery after stroke in the recovery period after a stroke lost motor function is slowly regained over a period of several weeks this process involves changes at the synaptic level but it not known whether microglia activity helps or hinders this process in genetically modified mice we control g protein signaling pathways in microglia with chemogenetic tools to asses the impact on the recovery process this project a collaboration with tim magnus group at the uke is supported by the dfg spp 2395 marie luise brehme charlotte oldenburg neighboring synapses collaboration or competition the formation and elimination of dendritic spines play an important role in structural remodeling of neuronal networks this process is highly dynamic and occurs over different timescales to get a better understanding of the dynamics of spine formation and interaction between nearby spines we image excitatory and inhibitory synapses over extended time periods up to several days using organotypic brain slice cultures as a model we are particularly interested in the removal of spines and the appearance of novel spines do these events have any repercussions in the local dendritic neighborhood are they shaped by homeostatic mechanisms kristina ponimaskine changes in synaptic ultrastructure after ltp synaptic plasticity events dynamic changes in the efficacy of synapses represent a major mechanism of information storage in the brain importantly synaptic plasticity is not only electrochemical but also structural and mechanical in nature an aspect that is often called structural plasticity to distinguish it from functional read out in my project i m particularly interested in studying the ultrastructural plasticity to reveal the material basis of information storage at synapses i generate the information by manipulating the synapse of interest optogenetically followed by electron microscope em imaging of the manipulated synapses for this purpose i use peroxidase based genetic tags hrp apex2 etc and correlative light electron microscopy clem to identify the synapses of interest combined with sparse transfection and non invasive stimulation strategies we investigate long term up to 3 days synaptic changes my aim is to establish a readout of synaptic plasticity at the ultrastructural level rui wang the function of endoplasmic reticulum er in spines the history of activity of a neuron affects the calcium concentration inside the endoplasmic reticulum er the er is a complex organelle distributed throughout neurons including the soma axon and dendritic arbor and is present in some dendritic spines while it is well known for its role in protein synthesis and transport and for its ability to release c...