Meta tags:
AUTHOR= JCI Insight;
Headings (most frequently used words):
in, abstract, authors, of, and, the, airway, cell, to, disease, muscle, with, cells, signaling, mice, by, human, fibrosis, smooth, through, associated, cd4, epithelial, reveals, induced, dependent, organ, lung, il, pulmonary, more, specific, growth, not, research, promotes, tumor, er, cancer, rna, protein, deficiency, impaired, genetic, background, program, hyperresponsiveness, progressive, via, identifies, as, for, single, involvement, transcriptomic, among, spatial, multiomics, biomedical, advances, beyond, transcriptomics, pathway, influences, developmental, susceptibility, from, mechanisms, development, remodeling, latest, physician, scientist, issue, characterizing, enteric, pathology, mps, iiia, suggests, vulnerability, lysosomal, storage, disorders, pik3ca, driven, cerebral, cavernous, malformations, does, require, microbiome, stimulation, estrogen, phenotypes, breast, ugdh, gpr30, noncoding, ty1, reverses, systemic, sclerosis, attenuating, cgas, sting, familial, case, flad1, adrenal, steroidogenesis, discovery, recognized, pertussis, antigens, that, reduce, colonization, glutamine, biosynthetic, pathways, fuel, autoreactive, foxp3, mediated, ketoglutarate, accelerates, cutaneous, wound, healing, modulating, fibroblast, niche, chromosome, pan, mapping, mosaic, loss, normal, specificity, frequency, phenotype, citrullinated, vary, activity, rheumatoid, arthritis, activation, megakaryocyte, α7, nachr, exacerbates, allergic, inflammation, 33, p38, mapk, pericardial, macrophages, suppress, cardiac, cystatin, after, myocardial, infarction, hypercapnia, enhances, contractility, stim1, ca2, role, mannose, binding, lectin, schistosoma, hypertension, regulation, purinergic, axis, contributes, cd8, dysregulation, stat3, gain, function, multiomic, analysis, subsets, interaction, idiopathic, 27, neutralization, without, antibiotics, an, approach, prevent, treat, neonatal, sepsis, local, hormone, benign, prostatic, hyperplasia, urinary, ykl, 40, diagnostic, biomarker, cystinosis, cxcr4, coordinates, adhesion, migration, nk, cross, model, atlas, conserved, osteopontin, polycystic, kidney, hypothalamic, neuroinflammation, ovariectomized, parallels, aging, related, changes, female, hypothalamus, sequencing, clonally, expanded, tissue, resident, memory, histidyl, trna, synthetase, myositis, plasma, proteins, chronic, graft, versus, host, zinc, restrains, multicellular, fibrotic, stabilization, pp2a, b56α, complex, overcomes, venetoclax, azacitidine, resistance, impairing, oxphos, aml, profiling, immune, malignant, pleural, effusions, macrophage, reprogramming, survival, feeding, mtorc1, regulates, postprandial, synthesis, endurance, but, size, endothelial, cycle, inhibition, enables, blood, vessel, maturation, normalize, vasculature, sign, up, email, alerts, cover, pdgfra, published, september, 2026, previous, press, preview, reviews, video, on, show, summary, otoshi, et, al, report, hyperactive, tgf, tnc, unleashed, brief, utero, exposure, vitamin, retinoic, acid, deficient, environment, resulting, structural, adult, image, shows, aberrant, ectopic, expansion, red, where, emerges, embryonic, near, distal, buds, sox9, green, progenitors, sox2, cyan, go, section, view, articles, topic, predoctoral, grant, writing, trainees, national, survey, barriers, facilitators, success, navigating, careers, insights, american, board, internal, medicine, graduates, shared, 21, expression, is, modulated, during, latent, coinfection,
Text of the page (most frequently used words):
and (253), the (158), with (104), cell (67), cells (65), for (61), that (58), pdf (57), text (57), #disease (40), from (34), muscle (33), authors (33), #abstract (32), signaling (32), cd4 (30), these (28), were (28), airway (28), associated (27), view (27), mice (25), research (24), are (22), patients (21), cancer (21), human (21), protein (19), tumor (19), lung (19), this (18), specific (18), clinical (17), immune (17), expression (17), activation (17), here (17), after (17), epithelial (17), changes (16), gene (16), function (16), our (16), increased (16), model (16), induced (16), dependent (15), through (15), tissue (15), estrogen (15), rna (14), genetic (14), role (14), was (14), pathways (13), organ (13), fibrosis (13), not (13), pathway (12), have (12), development (12), transcriptomic (12), single (12), treatment (12), mouse (12), normal (12), analysis (12), findings (12), models (12), lee (12), sarah (12), peter (12), liu (12), olga (12), pulmonary (11), inflammation (11), mtorc1 (11), across (11), revealed (11), cxcr4 (11), cit (11), progression (10), however (10), but (10), promotes (10), malignant (10), both (10), been (10), cystinosis (10), ykl (10), damage (10), cd8 (10), hypercapnia (10), flad1 (10), may (9), more (9), metabolic (9), biology (9), improved (9), therapeutic (9), blood (9), synthesis (9), pleural (9), inflammatory (9), using (9), aml (9), vivo (9), timothy (9), chen (9), identified (9), plasma (9), david (9), benjamin (9), kumar (9), dna (9), prostate (9), neonatal (9), megan (9), robert (9), jennifer (9), dysregulation (9), antigens (9), smooth (9), stim1 (9), via (9), alexander (9), pericardial (9), phenotypes (9), ssc (9), results (8), regulation (8), outcomes (8), physician (8), has (8), characterized (8), cycle (8), tissues (8), mediated (8), press (8), preview (8), loss (8), compared (8), response (8), remain (8), macrophages (8), resistance (8), levels (8), proteins (8), involvement (8), mutations (8), receptor (8), schistosoma (8), nachr (8), glutamine (8), breast (8), further (7), during (7), while (7), multiomics (7), advances (7), time (7), long (7), studies (7), mark (7), approaches (7), sequencing (7), activated (7), tsc2 (7), exhibit (7), related (7), phenotype (7), wang (7), scott (7), survival (7), patient (7), maria (7), demonstrated (7), pp2a (7), remodeling (7), fibrotic (7), background (7), chronic (7), trms (7), potential (7), progressive (7), kidney (7), sepsis (7), lungs (7), mbl (7), deficiency (7), myocardial (7), infarction (7), mloy (7), wound (7), program (7), ugdh (7), complex (6), mechanisms (6), spatial (6), scientist (6), vascular (6), aging (6), current (6), effects (6), exhibited (6), modulating (6), can (6), feeding (6), without (6), type (6), identify (6), which (6), showed (6), therapy (6), oxphos (6), production (6), b56α (6), key (6), primary (6), lynn (6), catherine (6), hill (6), study (6), significant (6), daniel (6), pathogenesis (6), systemic (6), subsets (6), reveals (6), audrey (6), hypothalamic (6), seq (6), early (6), age (6), zhong (6), yashchenko (6), zimmerman (6), jason (6), kurt (6), pkd (6), like (6), van (6), emily (6), adhesion (6), impaired (6), heather (6), neil (6), kim (6), growth (6), emt (6), bph (6), taylor (6), jonathan (6), axis (6), tgf (6), driven (6), eric (6), martin (6), michael (6), steven (6), cooper (6), stat3 (6), lectin (6), natalia (6), ali (6), cardiac (6), xiao (6), virginia (6), frequency (6), lawrence (6), chromosome (6), huang (6), yuan (6), foxp3 (6), autoreactive (6), vitaly (6), cgas (6), sting (6), ty1 (6), together (5), biomedical (5), beyond (5), transcriptomics (5), articles (5), andrew (5), promote (5), enhances (5), vasculature (5), limited (5), impairing (5), cdk4 (5), promoted (5), performed (5), similar (5), maturation (5), will (5), skm (5), despite (5), effusions (5), mpe (5), poor (5), microenvironment (5), benign (5), including (5), also (5), macrophage (5), cytokine (5), data (5), venetoclax (5), combination (5), enhanced (5), based (5), molecular (5), cgvhd (5), cross (5), had (5), biomarker (5), resident (5), memory (5), hormone (5), activity (5), within (5), about (5), interactions (5), stromal (5), gain (5), npgh (5), local (5), show (5), derived (5), developmental (5), elevated (5), purinergic (5), exposed (5), fibroblast (5), allergic (5), αkg (5), hyperresponsiveness (5), biosynthetic (5), pertussis (5), gpr30 (5), issue (5), email (4), alerts (4), latest (4), board (4), term (4), previous (4), pulmonology (4), public (4), health (4), oncology (4), metabolism (4), nicholas (4), price (4), whereas (4), normalize (4), specification (4), control (4), treated (4), vessel (4), decreased (4), mechanistic (4), target (4), mass (4), expressing (4), sclerosis (4), postprandial (4), fluid (4), flow (4), specimens (4), found (4), pro (4), tnf (4), hla (4), mechanism (4), reprogramming (4), provide (4), targets (4), profiling (4), identifies (4), romero (4), anna (4), brian (4), andrea (4), torres (4), azacitidine (4), acute (4), resistant (4), stabilization (4), host (4), used (4), idiopathic (4), autoimmune (4), myositis (4), high (4), consistent (4), enriched (4), collectively (4), poorly (4), hypothalamus (4), ovx (4), expressed (4), leading (4), atlas (4), their (4), known (4), demonstrate (4), critical (4), case (4), controls (4), diagnostic (4), cause (4), influences (4), infection (4), 27p28 (4), antibody (4), administration (4), significantly (4), ipf (4), respiratory (4), understood (4), distinct (4), support (4), interaction (4), gof (4), autoimmunity (4), drivers (4), functional (4), aberrant (4), disorders (4), exposure (4), deficient (4), analyses (4), noncoding (4), environment (4), cystatin (4), mks (4), remains (4), p38 (4), mapk (4), previously (4), th1 (4), healing (4), otoshi (4), susceptibility (4), bms493 (4), pathology (4), stimulated (4), adrenal (4), stimulation (4), letters (4), publication (4), journal (4), editors (4), american (3), investigation (3), reconstitution (3), suggest (3), between (3), accumulation (3), subsequently (3), drive (3), spatially (3), resolved (3), reviews (3), established (3), among (3), immunology (3), bone (3), dysfunctional (3), vessels (3), delivery (3), efficacy (3), malformations (3), endothelial (3), arterial (3), venous (3), defects (3), murine (3), tec (3), healthy (3), cellular (3), suppressed (3), landscape (3), relevance (3), improve (3), inhibition (3), contraction (3), two (3), akt (3), required (3), specifically (3), size (3), content (3), endurance (3), alterations (3), does (3), phosphorylation (3), regulates (3), morbidity (3), due (3), understanding (3), cytometry (3), upregulation (3), validated (3), finally (3), resource (3), into (3), novel (3), ven (3), aza (3), myeloid (3), drug (3), translational (3), lines (3), targeted (3), responses (3), population (3), stephanie (3), corey (3), cutler (3), ningxin (3), randolph (3), george (3), joseph (3), pidala (3), betty (3), hamilton (3), carrie (3), kitko (3), sally (3), arai (3), najla (3), jurdi (3), onstad (3), motoko (3), koyama (3), sophie (3), paczesny (3), geoffrey (3), graft (3), versus (3), methods (3), tested (3), considered (3), adjustment (3), baseline (3), variables (3), months (3), iqr (3), matched (3), following (3), skin (3), all (3), organs (3), decheng (3), reay (3), iago (3), pinal (3), fernandez (3), casal (3), dominguez (3), mammen (3), gaffen (3), oriss (3), dana (3), ascherman (3), transcriptional (3), signatures (3), histidyl (3), trna (3), synthetase (3), ifn (3), furthermore (3), other (3), expanded (3), jordana (3), bloom (3), encarnación (3), sidney (3), pereira (3), liliana (3), arvizu (3), sanchez (3), fontes (3), hadine (3), joffe (3), page (3), victor (3), navarro (3), kndy (3), networks (3), release (3), altered (3), level (3), establish (3), conserved (3), dysfunction (3), miller (3), hua (3), weidong (3), cordova (3), morgan (3), alex (3), zhang (3), daniyal (3), jafree (3), chelsea (3), christa (3), devette (3), vicki (3), maya (3), hignite (3), yohan (3), park (3), fariha (3), nusrat (3), bibi (3), maryam (3), sizhao (3), xiaoyan (3), jenny (3), gipson (3), xiaogang (3), mary (3), weiser (3), evans (3), bradley (3), yoder (3), cowley (3), katharina (3), hopp (3), stubbs (3), qin (3), anjun (3), polycystic (3), heterogeneity (3), mapping (3), osteopontin (3), resulted (3), severity (3), created (3), new (3), shira (3), eisman (3), francesca (3), grossberg (3), batya (3), koenigsberg (3), mcdermott (3), frédérique (3), den (3), haak (3), luis (3), pedroza (3), everardo (3), hegewisch (3), solloa (3), philip (3), murphy (3), mace (3), central (3), its (3), peripheral (3), contact (3), motility (3), migration (3), greenberg (3), serena (3), souza (3), thiessen (3), philbrook (3), wassim (3), obeid (3), avi (3), rosenberg (3), elena (3), levtchenko (3), koenraad (3), veys (3), susan (3), furth (3), chirag (3), parikh (3), urine (3), over (3), higher (3), than (3), masaki (3), ryuzaki (3), svetlana (3), zonis (3), bhowmick (3), sandrine (3), billet (3), saravana (3), kailasam (3), mani (3), stephen (3), freedland (3), hyung (3), vera (3), chesnokova (3), shlomo (3), melmed (3), mesenchymal (3), prostatic (3), hyperplasia (3), increases (3), adjacent (3), madhavi (3), annamanedi (3), jessica (3), povroznik (3), samantha (3), arevalo (3), marcano (3), cory (3), robinson (3), issues (3), burden (3), pups (3), bacterial (3), reduced (3), approach (3), ana (3), serezani (3), julia (3), bazzano (3), bruno (3), pascoalino (3), ludmilla (3), silva (3), abigail (3), dietrich (3), chase (3), sherrill (3), annika (3), vannan (3), carla (3), calvi (3), paula (3), gonzalez (3), ericsson (3), erin (3), wilfong (3), matthew (3), bacchetta (3), ciara (3), shaver (3), lorraine (3), ware (3), margaret (3), salisbury (3), luc (3), kaer (3), banovich (3), kropski (3), blackwell (3), localized (3), jose (3), campos (3), duran (3), montana (3), knight (3), samir (3), sayed (3), dalalo (3), mauracher (3), peyton (3), conrey (3), aaron (3), schultz (3), ceire (3), hay (3), lindell (3), ilona (3), neale (3), kyle (3), yeakle (3), abrams (3), erica (3), schmitt (3), thelin (3), christian (3), howard (3), sara (3), bluestein (3), christine (3), seroogy (3), tamara (3), pozos (3), akaluck (3), thatayatikom (3), ingrid (3), lundgren (3), amelie (3), gauthier (3), canna (3), helen (3), keller (3), ottavia (3), delmonte (3), lisa (3), forbes (3), satter (3), holland (3), jenna (3), bergerson (3), leiding (3), romberg (3), bailis (3), christopher (3), hunter (3), alexandra (3), freeman (3), alejandro (3), villarino (3), anderson (3), tiphanie (3), vogel (3), henrickson (3), variants (3), pathogenic (3), adenosine (3), suggests (3), plays (3), common (3), contributes (3), claudia (3), mickael (3), dara (3), fonseca (3), balladares (3), rahul (3), kevin (3), nolan (3), linda (3), sanders (3), katie (3), tuscan (3), ramraj (3), prasad (3), pilar (3), londono (3), fernanda (3), oliveira (3), kennedi (3), pyper (3), ari (3), molofsky (3), rubin (3), tuder (3), stenmark (3), graham (3), schistosomiasis (3), hypertension (3), immunity (3), complement (3), th2 (3), mannose (3), binding (3), assessed (3), protected (3), protection (3), when (3), masahiko (3), shigemura (3), vitalii (3), kryvenko (3), pacheco (3), puckelwartz (3), milos (3), aleksic (3), magnani (3), emma (3), thompson (3), francisco (3), javier (3), eoin (3), cummins (3), werner (3), seeger (3), andreas (3), bräuninger (3), welch (3), budinger (3), emilia (3), lecuona (3), laura (3), dada (3), ankit (3), bharat (3), istván (3), vadász (3), murali (3), prakriya (3), jacob (3), sznajder (3), asm (3), molecule (3), erk (3), ca2 (3), contractility (3), fatehi (3), hassanabad (3), sarthak (3), sinha (3), arzina (3), jaffer (3), darrell (3), belke (3), nicole (3), rosin (3), elodie (3), labit (3), young (3), friederike (3), schoettler (3), keerthana (3), chockalingam (3), haeyul (3), jameson (3), dundas (3), emilie (3), chantal (3), carmina (3), isidoro (3), tam (3), hanjoo (3), shim (3), zarzycki (3), afshin (3), derakhshani (3), elisabeth (3), gorgiogianni (3), jeannine (3), turnbull (3), antoine (3), dufour (3), shalina (3), ousman (3), jeff (3), biernaskie (3), paul (3), fedak (3), justin (3), deniset (3), structural (3), samples (3), driver (3), hang (3), rujia (3), tao (3), shitao (3), xie (3), yao (3), zhou (3), jin (3), zhenwei (3), xia (3), mechanistically (3), cliff (3), rims (3), hannah (3), deberg (3), sylvia (3), posso (3), muir (3), hannes (3), uchtenhagen (3), anne (3), hocking (3), bukiri (3), jeffrey (3), carlin (3), bernard (3), linsley (3), eddie (3), james (3), jane (3), buckner (3), rheumatoid (3), arthritis (3), citrullinated (3), epitopes (3), aggrecan (3), vimentin (3), fibrinogen (3), responders (3), antigen (3), arkadiusz (3), gertych (3), huihui (3), xingyu (3), vail (3), krishnan (3), ramanujan (3), lauren (3), brady (3), true (3), nelson (3), carroll (3), dan (3), theodorescu (3), male (3), mosaic (3), pan (3), carcinoma (3), histologically (3), yuhan (3), weimin (3), lin (3), denghao (3), yueying (3), yimeng (3), cai (3), jie (3), xiang (3), linfeng (3), xinxing (3), shuai (3), yin (3), shuang (3), jiang (3), malcolm (3), xing (3), leixiao (3), quan (3), process (3), ketoglutarate (3), formation (3), takehiro (3), kotton (3), ayyappa (3), kameshwar (3), yoshinori (3), seki (3), zachary (3), cardell (3), xiangyi (3), yuta (3), matsuno (3), pooja (3), rajaram (3), youn (3), kyung (3), sharpton (3), loredana (3), quadro (3), wellington (3), cardoso (3), masako (3), suzuki (3), ahr (3), intrauterine (3), acid (3), pdgfra (3), mohammad (3), adeel (3), zafar (3), charlotte (3), machado (3), jyotirmaya (3), behera (3), yuelin (3), shakchhi (3), joshi (3), yassine (3), fazaa (3), camacho (3), georgiev (3), kiran (3), kurmi (3), marcia (3), haigis (3), louis (3), marie (3), charbonnier (3), autoantibody (3), effect (3), vulnerability (3), mohamed (3), shamseldin (3), jesse (3), hall (3), griffin (3), gabrielle (3), hernandez (3), yue (3), alexa (3), aubrey (3), eva (3), verzani (3), rajendar (3), deora (3), amy (3), lovett (3), racke (3), abelin (3), purnima (3), dubey (3), vaccine (3), tract (3), averina (3), kalinchenko (3), ioutsi (3), andrey (3), pirogov (3), bogachev (3), oleg (3), permyakov (3), buev (3), ekaterina (3), guseva (3), anastasia (3), priymak (3), bazhanova (3), mariia (3), emelianova (3), grigoryeva (3), galina (3), baydakova (3), maxim (3), abakumov (3), vasily (3), manskikh (3), dontsova (3), petr (3), sergiev (3), anatoly (3), tiulpakov (3), r542 (3), xaviar (3), jones (3), salwa (3), soussi (3), alessandra (3), ciullo (3), kara (3), tsi (3), weixin (3), liang (3), mario (3), fournier (3), thassio (3), mesquita (3), alberto (3), marchevsky (3), nunzio (3), bottini (3), francesco (3), boin (3), ahmed (3), ibrahim (3), eduardo (3), marbán (3), meghan (3), annee (3), nguyen (3), corinne (3), strawser (3), trupti (3), trivedi (3), cesar (3), baeta (3), lavau (3), jovita (3), byemerwa (3), debarati (3), mukherjee (3), suzanne (3), wardell (3), sandeep (3), artham (3), vardhman (3), shyni (3), varghese (3), rory (3), goodwin (3), noncanonical (3), xinchen (3), mao (3), zhuo (3), hwang (3), jun (3), junrou (3), haikuo (3), technical (3), review (3), lun (3), rhonda (3), lightle (3), bader (3), georgeio (3), sader (3), shenkar (3), sean (3), polster (3), douglas (3), marchuk (3), jan (3), karl (3), burkhardt (3), issam (3), awad (3), kahn (3), ewa (3), ziółkowska (3), letitia (3), williams (3), elizabeth (3), eultgen (3), grace (3), kick (3), xukai (3), ding (3), sorensen (3), balraj (3), doray (3), patricia (3), dickson (3), heuckeroth (3), sign (2), 2026 (2), highlight (2), diverse (2), types (2), ultimately (2), extracellular (2), matrix (2), coordinated (2), epigenetic (2), activities (2), determine (2), internal (2), medicine (2), scientists (2), increasing (2), insights (2), grant (2), writing (2), essential (2), success (2), nih (2), survey (2), vaccines (2), stem (2), reproductive (2), nephrology (2), hematology (2), endocrinology (2), covid (2), cardiology (2), angiogenesis (2), genet (2), karen (2), inhibitor (2), tecs (2), disrupted (2), investigate (2), scrnaseq (2), tumors (2), pericyte (2), association (2), immunosuppressive (2), hypoxia (2), immunotherapy (2), thus (2), contrast (2), strategies (2), enables (2), rapamycin (2), mtor (2), complex1 (2), major (2), phosphorylated (2), skeletal (2), myofiber (2), capacity (2), modest (2), mitochondrial (2), therefore (2), part (2), gaps (2), bpe (2), states (2), fibronectin (2), markers (2), multiplex (2), they (2), value (2), rewiring (2), relapse (2), leukemia (2), energy (2), represents (2), strategy (2), pharmacological (2), tools (2), relevant (2), work (2), overcomes (2), you (2), zinc (2), restrains (2), multicellular (2), sectional (2), whether (2), biomarkers (2), manifestations (2), help (2), measured (2), gvhd (2), correlations (2), individual (2), diagnosis (2), draw (2), donors (2), unrelated (2), eye (2), transplant (2), independent (2), conclusion (2), iim (2), important (2), trm (2), basis (2), genes (2), low (2), profile (2), profiles (2), contribute (2), innate (2), regulatory (2), pronounced (2), expansion (2), stable (2), clonally (2), temporal (2), physiological (2), measurements (2), serum (2), progressively (2), then (2), declined (2), endocrine (2), humans (2), glial (2), emerging (2), particularly (2), confirmed (2), nucleus (2), withdrawal (2), available (2), patterns (2), preclinical (2), platform (2), targeting (2), neuroinflammation (2), ovariectomized (2), parallels (2), female (2), such (2), onset (2), rate (2), elucidate (2), consequences (2), integrated (2), scrna (2), whole (2), spp1 (2), clusters (2), deletion (2), researchers (2), progenitors (2), chemokine (2), cxcl12 (2), regulators (2), niches (2), developing (2), blockade (2), integrin (2), ligands (2), imaging (2), providing (2), modulation (2), plerixafor (2), precursors (2), coordinates (2), family (2), children (2), egfr (2), lfd (2), developed (2), fold (2), 0001 (2), excellent (2), auc (2), superior (2), technologies (2), management (2), urinary (2), transition (2), epithelium (2), ghr (2), action (2), number (2), γh2ax (2), twist2 (2), ki67 (2), proliferation (2), fibroblasts (2), along (2), igf (2), enable (2), predominant (2), mortality (2), severely (2), weight (2), adulthood (2), prior (2), clearance (2), gentamicin (2), glucose (2), vital (2), infected (2), neutralization (2), antibiotics (2), prevent (2), treat (2), 000 (2), revealing (2), rare (2), non (2), observed (2), near (2), factor (2), concept (2), multiomic (2), lymphoproliferation (2), implicated (2), exist (2), state (2), evaluation (2), downstream (2), produce (2), impact (2), necessary (2), hypothesis (2), lacking (2), marrow (2), knockout (2), caused (2), co2 (2), copd (2), active (2), rapidly (2), transcription (2), under (2), mmhg (2), soce (2), lower (2), pericardium (2), protective (2), actions (2), effector (2), suppress (2), antiinflammatory (2), allergen (2), challenged (2), chrna7 (2), gts (2), challenge (2), proinflammatory (2), megakaryocyte (2), exacerbates (2), knowledge (2), class (2), computational (2), intermediate (2), cohort (2), frequent (2), dynamic (2), specificity (2), vary (2), loy (2), linked (2), degree (2), men (2), fish (2), assay (2), image (2), ychrfish (2), involved (2), repair (2), accelerates (2), cutaneous (2), niche (2), perturbations (2), adult (2), abnormalities (2), embryos (2), selectively (2), vitamin (2), retinoic (2), smad2 (2), tnc (2), utero (2), tolerance (2), treg (2), sustained (2), conventional (2), processes (2), fuel (2), immunized (2), discovery (2), recognized (2), reduce (2), colonization (2), fad (2), described (2), carrying (2), compound (2), heterozygous (2), resulting (2), a418v (2), insufficiency (2), mutation (2), homozygous (2), therapies (2), familial (2), steroidogenesis (2), report (2), reverses (2), attenuating (2), widely (2), responsive (2), udp (2), vitro (2), knockdown (2), blunted (2), pik3ca (2), cerebral (2), cavernous (2), require (2), microbiome (2), characterizing (2), enteric (2), mps (2), iiia (2), lysosomal (2), storage (2), cover (2), job (2), advertising (2), transfers (2), ethics (2), stats (2), consulting (2), top (2), read (2), perspectives (2), editorials (2), collections (2), past (2), jci (2), insight (2), javascript (2), copyright, issn, 2379, 3708, society, episode, riti, sharan, explains, compartment, deficit, warrant, modulated, latent, coinfection, video, involves, interplay, leads, pathologic, excessive, shared, abim, designed, train, shortening, postgraduate, training, surveyed, navigating, careers, graduates, effective, skill, achieve, academic, independence, career, receiving, f30, predoctoral, trainees, national, barriers, facilitators, advertisement, virology, transplantation, therapeutics, otology, ophthalmology, neuroscience, microbiology, infectious, hepatology, genetics, gastroenterology, dermatology, trials, aids, hiv, topic, shelby, cain, gael, nafiisha, jordon, aragon, madeline, jackson, victoria, milosek, schwartz, umadevi, paila, aleksandra, cwiek, zaneta, markowska, chavkin, richard, dudley, hirschi, similarly, hyperproliferation, corrected, palbociclib, cyclin, kinase, beneficial, well, mammary, ecs, enabling, untreated, arrest, junctions, glycolytic, perfusion, favorable, datasets, recruitment, maintained, continued, highlighting, samuel, lapp, krystle, kalafut, madi, cissé, khaled, tighanimine, dean, rosenthal, doxsey, sheng, hui, inouye, claire, morrow, yann, cormerais, brendan, manning, separates, modes, mutant, tuberous, cannot, attenuate, maintain, differences, atrophy, ribosomal, maximal, contractile, occurs, glycogen, coincide, increase, induction, dispensable, maintenance, sedentary, aaditya, khatri, huimin, zhicheng, prekshaben, patel, smita, nair, javid, mohammed, beth, shaz, nixon, palmer, kamran, mahmood, validation, cd45, eight, five, interferon, good, tumorigenic, tgfβ, surface, enrichment, il17a, putative, rich, interrogating, present, spectrum, offer, only, prognostic, collection, silvia, murillo, irene, peris, lucianò, nerea, marcotegui, carmen, vicente, tran, kelsey, barrie, caitlin, connor, lópez, mateos, cayuela, victoriano, mulero, joaquín, fernández, irigoyen, enrique, santamaría, odero, goutham, narla, reliance, oxidative, exciting, face, unmet, need, recently, phosphatase, apoptotic, leveraging, unbiased, multi, omics, define, roles, suppressor, perspective, heterocomplex, glue, activator, rpt04402, reduces, improves, sensitive, supports, counteract, historically, jianfei, wenjing, xiaoli, sun, peng, zhao, letter, goal, evaluate, guide, choice, 695, consortium, less, benjamini, hochberg, median, remainder, umbilical, cord, haploidentical, mismatched, methotrexate, calcineurin, prophylaxis, overall, 326, moderate, 244, severe, mouth, joint, liver, batch, characteristics, aucs, except, least, fit, adjusting, actionable, future, investigations, focus, granular, immediately, proximal, determinants, precise, underlying, myopathy, undefined, there, recognition, play, reported, very, multimodal, prominent, inflamed, encoding, cd69, cxcr6, runx3, prdm1, alongside, klf2, ccr7, sell, s1pr1, tcf7, generally, reports, signature, validate, comparison, detailed, indicates, tcr, clonotype, distribution, cdr3, sequence, similarity, clonal, relative, pattern, remained, weeks, immunization, occur, ovarian, comprehensive, characterization, ovariectomy, combining, bulk, posterior, preoptic, area, days, luteinizing, rose, core, temperature, peaked, normalized, recapitulating, thermoregulatory, dynamics, neuron, most, immunofluorescence, neurokinin, declining, neuronal, heightened, astrocytic, reactivity, arcuate, prolonged, contextualize, analyzed, publicly, chronological, correlation, framework, neuroinflammatory, species, testing, interventions, menopause, arises, cilia, pkd1, pkd2, renal, end, stage, largely, environmental, modifiers, regards, mutated, constructed, composition, intercellular, global, pkd1rc, reduction, cyst, freely, searchable, website, https, bmblx, bmi, osumc, edu, scpkd, intra, guiding, treating, natural, killer, undergo, stepwise, differentiation, multipotent, secondary, lymphoid, importance, little, regulate, trafficking, ligand, throughout, tonsil, containing, pharmacologic, disruption, diminished, resolution, crosstalk, integrins, engagement, speed, requirement, antagonist, amd3100, generation, cd34, whim, syndrome, supporting
Text of the page (random words):
ie p vogel sarah e henrickson view text pdf impaired regulation by purinergic signaling axis contributes to cd8 t cell dysregulation in stat3 gain of function text pdf abstract gain of function gof variants in stat3 cause a complex disorder characterized by early onset autoimmunity lymphoproliferation recurrent infections and immune dysregulation in both primary human and mouse models of stat3 gof cd8 t cells have been implicated as pathogenic drivers of autoimmunity though the exact mechanisms remain poorly understood here we found that in patients with stat3 gof cd8 t cells exist in an activated state functional assessment revealed that naive cd8 t cells have an increased capacity for ifn γ and tnf α production with type i and type ii ifn transcriptional signatures evaluation of immunoregulatory pathways revealed dysregulation of the purinergic signaling axis in cd8 t cells cd39 was increased whereas downstream purinergic family members cd73 and the adenosine receptor a2ar were downregulated impairing the potential to produce or sense immunosuppressive adenosine evaluation of the impact of precision therapy in the form of jak inhibition at a cellular and functional level revealed partial normalization of cd8 t cell dysregulation in patients including aberrant cytokine production our study suggests that a dysregulated purinergic signaling axis plays a key role in cd8 t cell dysregulation in stat3 gof and may have implications for other rare monogenic immune disorders and common inflammatory disorders authors jose s campos duran montana s knight samir u sayed megan c dalalo andrea a mauracher peyton conrey aaron b schultz ceire a hay robert b lindell ilona neale kyle yeakle eric d abrams erica g schmitt martin a thelin christian a howard sara bluestein christine m seroogy tamara c pozos akaluck thatayatikom ingrid s lundgren amelie gauthier scott w canna helen c su michael d keller ottavia m delmonte lisa r forbes satter steven m holland jenna r e bergerson jennifer w leiding neil romberg will bailis christopher a hunter alexandra f freeman alejandro v villarino mark s anderson megan a cooper tiphanie p vogel sarah e henrickson multiomic analysis identifies t cell subsets and mechanisms of epithelial interaction in idiopathic pulmonary fibrosis ana p m serezani julia m r bazzano bruno d pascoalino ludmilla da silva abigail j dietrich chase j taylor taylor sherrill annika vannan carla l calvi paula i gonzalez ericsson erin m wilfong matthew bacchetta ciara m shaver lorraine b ware margaret l salisbury luc van kaer nicholas e banovich jonathan a kropski timothy s blackwell ana p m serezani julia m r bazzano bruno d pascoalino ludmilla da silva abigail j dietrich chase j taylor taylor sherrill annika vannan carla l calvi paula i gonzalez ericsson erin m wilfong matthew bacchetta ciara m shaver lorraine b ware margaret l salisbury luc van kaer nicholas e banovich jonathan a kropski timothy s blackwell view text pdf multiomic analysis identifies t cell subsets and mechanisms of epithelial interaction in idiopathic pulmonary fibrosis text pdf abstract idiopathic pulmonary fibrosis ipf is a fatal interstitial lung disease characterized by progressive scarring and respiratory failure while t cells are elevated in ipf lungs their contributions to fibrosis beyond inflammation remain poorly understood here we performed multiplex imaging and single cell rna and protein profiling on about 90 000 cd3 t cells from control and fibrotic lungs revealing 11 distinct subsets of cd4 and cd8 t cells including a rare cd56 regulatory t cell in addition to increased t cell numbers in severely fibrotic lungs compared with non diseased controls we observed cd4 and cd8 t cells localized near epithelial cells and in niches of abnormal epithelium cxcr4 mif signaling emerged as a central axis mediating t cell epithelial interactions while epidermal growth factor receptor egfr and tgf β pathways dominated in multiple t cell subsets our findings support the concept that t cells in ipf adopt nonclassical activation patterns that are driven by epithelial interactions within the fibrotic microenvironment these studies provide a foundation for exploring alternative therapeutic strategies in ipf lungs by modulating t cell behavior and communication networks authors ana p m serezani julia m r bazzano bruno d pascoalino ludmilla da silva abigail j dietrich chase j taylor taylor sherrill annika vannan carla l calvi paula i gonzalez ericsson erin m wilfong matthew bacchetta ciara m shaver lorraine b ware margaret l salisbury luc van kaer nicholas e banovich jonathan a kropski timothy s blackwell il 27 neutralization with and without antibiotics as an approach to prevent and treat neonatal sepsis madhavi annamanedi jessica m povroznik samantha arevalo marcano cory m robinson madhavi annamanedi jessica m povroznik samantha arevalo marcano cory m robinson view text pdf il 27 neutralization with and without antibiotics as an approach to prevent and treat neonatal sepsis text pdf abstract neonatal sepsis is a predominant cause of neonatal mortality and long term morbidity that severely affects preterm and low birth weight newborns antibiotic resistance and long term developmental issues associated with neonatal sepsis necessitate finding new and improved treatment options il 27 has diverse influences on the immune response is elevated during the neonatal period compared with adulthood and continues to rise further during infection elevated levels of il 27 early in life predispose the host to impaired control of the pathogen burden and increased mortality this study explored the therapeutic potential of il 27p28 antibody administration to improve treatment outcomes during murine neonatal sepsis sepsis was induced by subcutaneous inoculation of k1 encapsulated e coli and the neonatal pups were rescued with il 27p28 monoclonal antibody pups that received prophylactic antibody prior to the infection demonstrated superior bacterial clearance and significant weight gain compared with controls during infection the combination of subclinical dose of gentamicin along with il 27p28 antibody administered 2 hours after infection significantly improved bacterial clearance and glucose homeostasis with reduced serum levels of il 6 and tnf α vital organ damage and improved the survival rate of infected pups compared with gentamicin alone these findings suggest that il 27p28 antagonization represents a promising therapeutic tool for treatment of neonatal sepsis authors madhavi annamanedi jessica m povroznik samantha arevalo marcano cory m robinson local growth hormone promotes benign prostatic hyperplasia masaki ryuzaki svetlana zonis neil a bhowmick sandrine billet saravana kumar kailasam mani stephen j freedland hyung l kim vera chesnokova shlomo melmed masaki ryuzaki svetlana zonis neil a bhowmick sandrine billet saravana kumar kailasam mani stephen j freedland hyung l kim vera chesnokova shlomo melmed view text pdf local growth hormone promotes benign prostatic hyperplasia text pdf abstract locally produced nonpituitary growth hormone npgh promotes dna damage accumulation and epithelial mesenchymal transition emt in aging human colon epithelium gh receptor ghr and npgh are expressed in normal human prostate and benign prostatic hyperplasia bph prevalence increases with age we hypothesized that local prostate gh action may promote emt and contribute to bph pathogenesis we show here that the number of patients expressing npgh increases more than 10 fold after age 60 concordant with increased γh2ax a marker of dna damage and emt activation gh treated human primary prostate epithelial cells normal prostate cells and primary cell cultures derived from resected bph specimens exhibited enhanced dna damage and activated emt with induced twist2 suppressed e cadherin and increased ki67 cell motility and proliferation in mice prostate tissue adjacent to allografted gh expressing fibroblasts showed increased γh2ax twist2 and ki67 along with morphological changes consistent with bph while gh and gh induced igf 1 both activated emt gh triggered dna damage independently of igf 1 these results elucidate what we believe to be a novel role for local npgh in aging prostate tissue whereby npgh increases dna damage and promotes emt to enable a microenvironment favoring bph development prostate ghr signaling may be an attractive therapeutic target for bph authors masaki ryuzaki svetlana zonis neil a bhowmick sandrine billet saravana kumar kailasam mani stephen j freedland hyung l kim vera chesnokova shlomo melmed urinary ykl 40 as a diagnostic biomarker for cystinosis jason h greenberg serena d souza heather r thiessen philbrook wassim obeid avi z rosenberg elena levtchenko koenraad veys susan l furth chirag r parikh jason h greenberg serena d souza heather r thiessen philbrook wassim obeid avi z rosenberg elena levtchenko koenraad veys susan l furth chirag r parikh view text pdf clinical research and public health urinary ykl 40 as a diagnostic biomarker for cystinosis text pdf abstract early diagnosis of cystinosis is critical to limit disease progression ykl 40 a protein in the chitinase family released by inflammatory cells may be a useful biomarker for cystinosis in a case control study of 10 children with cystinosis and 20 without cystinosis matched by age and baseline egfr we measured urine ykl 40 ngal and egf a lateral flow device lfd for ykl 40 was also developed and tested urine ykl 40 was over 200 fold higher in children with cystinosis 64 6 ng ml iqr 23 4 83 8 compared with controls 0 3 iqr 0 3 0 79 p 0 0001 with excellent diagnostic discrimination auc 0 99 that was superior to other biomarkers lfd measurements for ykl 40 showed similar results auc 0 93 ykl 40 results were verified in 5 cystinosis patients and ykl 40 staining was markedly higher in kidney biopsies from cystinosis patients than in healthy controls urine ykl 40 has excellent diagnostic potential for cystinosis and point of care technologies may facilitate early screening and management of this disease authors jason h greenberg serena d souza heather r thiessen philbrook wassim obeid avi z rosenberg elena levtchenko koenraad veys susan l furth chirag r parikh cxcr4 coordinates adhesion migration and development of human nk cells shira e eisman francesca e grossberg batya s koenigsberg david h mcdermott frédérique van den haak luis a pedroza everardo hegewisch solloa philip m murphy emily m mace shira e eisman francesca e grossberg batya s koenigsberg david h mcdermott frédérique van den haak luis a pedroza everardo hegewisch solloa philip m murphy emily m mace view text pdf cxcr4 coordinates adhesion migration and development of human nk cells text pdf abstract natural killer nk cells undergo stepwise differentiation from multipotent progenitors within secondary lymphoid tissues despite the central importance of the tissue microenvironment in their development little is known about cell cell interactions that regulate human nk cell trafficking and maturation here we identify the chemokine receptor cxcr4 and its ligand cxcl12 as regulators of stromal nk cell interactions required for nk cell maturation we demonstrate that cxcr4 is expressed throughout human nk cell development in peripheral blood and tonsil and cxcl12 is enriched in stromal niches containing developing nk cells pharmacologic blockade or genetic disruption of cxcr4 resulted in diminished adhesion to integrin ligands and high resolution imaging demonstrated crosstalk between cxcr4 and integrins providing a mechanistic basis for chemokine dependent modulation of adhesion further cxcr4 blockade resulted in altered contact dependent motility on stromal cells and integrin ligands with decreased stable stromal engagement and increased cell speed consistent with a requirement for these interactions treatment with the cxcr4 antagonist plerixafor amd3100 impaired nk cell generation from cd34 precursors analysis of nk cells from patients with whim syndrome with cxcr4 gain of function mutations treated with plerixafor revealed similar defects in migration and adhesion supporting the in vivo relevance of cxcr4 dependent regulation of nk cell adhesion and motility authors shira e eisman francesca e grossberg batya s koenigsberg david h mcdermott frédérique van den haak luis a pedroza everardo hegewisch solloa philip m murphy emily m mace a cross model single cell atlas reveals conserved involvement of osteopontin in polycystic kidney disease sarah j miller hua zhong weidong wu audrey m cordova morgan e yashchenko alex yashchenko zhang li daniyal j jafree chelsea n zimmerman christa i devette vicki do maya e hignite yohan park fariha nusrat bibi maryam sizhao lu xiaoyan li jenny r gipson xiaogang li david a long mary c m weiser evans bradley k yoder benjamin d cowley jr katharina hopp jason r stubbs qin ma anjun ma kurt a zimmerman sarah j miller hua zhong weidong wu audrey m cordova morgan e yashchenko alex yashchenko zhang li daniyal j jafree chelsea n zimmerman christa i devette vicki do maya e hignite yohan park fariha nusrat bibi maryam sizhao lu xiaoyan li jenny r gipson xiaogang li david a long mary c m weiser evans bradley k yoder benjamin d cowley jr katharina hopp jason r stubbs qin ma anjun ma kurt a zimmerman view text pdf a cross model single cell atlas reveals conserved involvement of osteopontin in polycystic kidney disease text pdf abstract polycystic kidney disease pkd arises from mutations in cilia associated genes such as pkd1 and pkd2 expressed in renal epithelial cells leading to progressive kidney dysfunction and end stage kidney disease patients with pkd exhibit significant heterogeneity in disease progression largely due to genetic and environmental modifiers like patients mouse models of pkd also exhibit significant heterogeneity with regards to the gene mutated age of disease onset and rate of disease progression to elucidate the cellular and molecular consequences of these variables we constructed an integrated single cell rna sequencing scrna seq atlas across mouse models of pkd mapping changes in cell type composition gene expression and intercellular signaling networks across the whole atlas and within individual models across models scrna seq data revealed increased spp1 osteopontin expression and signaling from pkd enriched clusters global deletion of spp1 in pkd1rc rc mice resulted in a modest reduction in cyst severity and improved kidney function from these studies we created a freely available searchable website https bmblx bmi osumc edu scpkd that can be used to identify cross and intra model changes in gene expression guiding researchers to new therapeutic targets for treating pkd authors sarah j miller hua zhong weidong wu audrey m cordova morgan e yashchenko alex yashchenko zhang li daniyal j jafree chelsea n zimmerman christa i devette vicki do maya e hignite yohan park fariha nusrat bibi maryam sizhao lu xiaoyan li jenny r ...
|
