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culture edit availability edit halothane is available as a volatile liquid at 30 50 200 and 250 ml per container but in many developed nations is not available having been displaced by newer agents 46 a major producer of halothane for anesthetic purposes piramal pharma ceased production of halothane at the end of 2023 which has led to dwindling supplies 47 48 it is the only inhalational anesthetic containing bromine which makes it radiopaque 49 it is colorless and pleasant smelling but unstable in light it is packaged in dark colored bottles and contains 0 01 thymol as a stabilizing agent 20 greenhouse gas edit owing to the presence of covalently bonded fluorine halothane absorbs in the atmospheric window and is therefore a greenhouse gas however it is much less potent than most other chlorofluorocarbons and bromofluorocarbons due to its short atmospheric lifetime estimated at only one year vis à vis over 100 years for many perfluorocarbons 50 despite its short lifespan halothane still has a global warming potential 50 times that of carbon dioxide although this is over 100 times smaller than the most abundant fluorinated gases and about 800 times smaller than the gwp of sulfur hexafluoride over 500 years 51 halothane is believed to make a negligible contribution to global warming 50 ozone depletion edit halothane is an ozone depleting substance with an odp of 1 56 and it is calculated to be responsible for 1 of total stratospheric ozone layer depletion 12 13 unlike most ozone depleting substances it is not governed under the montreal protocol 52 references edit anvisa 31 march 2023 rdc nº 784 listas de substâncias entorpecentes psicotrópicas precursoras e outras sob controle especial collegiate board resolution no 784 lists of narcotic psychotropic precursor and other substances under special control in brazilian portuguese diário oficial da união published 4 april 2023 archived from the original on 3 august 2023 retrieved 16 august 2023 halothane usp dailymed 18 september 2013 retrieved 11 february 2022 1 2 fluothane fda approved drugs u s food and drug administration retrieved 12 february 2022 1 2 halothane drugbank db01159 1 2 3 4 5 6 world health organization 2009 stuart mc kouimtzi m hill sr eds who model formulary 2008 world health organization pp 17 8 hdl 10665 44053 isbn 978 92 4 154765 9 yentis sm hirsch np ip j 2013 anaesthesia and intensive care a z an encyclopedia of principles and practice 5th ed elsevier health sciences p 264 isbn 978 0 7020 5375 7 archived from the original on 10 september 2017 1 2 james mf hift rj july 2000 porphyrias british journal of anaesthesia 85 1 143 53 doi 10 1093 bja 85 1 143 pmid 10928003 1 2 3 4 halothane fda prescribing information side effects and uses www drugs com june 2005 archived from the original on 21 december 2016 retrieved 13 december 2016 bricker s 17 june 2004 the anaesthesia science viva book cambridge university press p 161 isbn 978 0 521 68248 0 archived from the original on 10 september 2017 via google books walker sr 2012 trends and changes in drug research and development springer p 109 isbn 978 94 009 2659 2 archived from the original on 10 september 2017 world health organization 2025 the selection and use of essential medicines 2025 report of the 25th who expert committee on selection and use of essential medicines executive summary geneva world health organization doi 10 2471 b09544 hdl 10665 382350 1 2 kümmerer k 2013 pharmaceuticals in the environment sources fate effects and risks springer p 33 isbn 978 3 662 09259 0 1 2 langbein t sonntag h trapp d hoffmann a malms w röth ep et al january 1999 volatile anaesthetics and the atmosphere atmospheric lifetimes and atmospheric effects of halothane enflurane isoflurane desflurane and sevoflurane british journal of anaesthesia 82 1 66 73 doi 10 1093 bja 82 1 66 pmid 10325839 lobo sa ojeda j dua a singh k lopez j 2022 minimum alveolar concentration statpearls treasure island fl statpearls publishing pmid 30422569 nbk532974 bezuidenhout e november 2020 the blood gas partition coefficient southern african journal of anaesthesia and analgesia 1 3 s8 s11 doi 10 36303 sajaa 2020 26 6 s3 2528 eissn 2220 1173 issn 2220 1181 halothane anesthesia general 31 october 2010 archived from the original on 16 february 2011 subrahmanyam m mohan s september 2013 safety features in anaesthesia machine indian j anaesth 57 5 472 480 doi 10 4103 0019 5049 120143 pmc 3821264 pmid 24249880 habibollahi p mahboobi n esmaeili s safari s dabbagh a alavian sm january 2018 halothane livertox clinical and research information on drug induced liver injury internet national institute of diabetes and digestive and kidney diseases pmid 31643481 nbk548151 wark h earl j chau dd overton j april 1990 halothane metabolism in children british journal of anaesthesia 64 4 474 481 doi 10 1093 bja 64 4 474 pmid 2334622 1 2 gyorfi mj kim py 2022 halothane toxicity statpearls treasure island fl statpearls publishing pmid 31424865 nbk545281 hankins dc kharasch ed 9 may 1997 determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography journal of chromatography b biomedical sciences and applications 692 2 413 8 doi 10 1016 s0378 4347 96 00527 0 issn 0378 4347 pmid 9188831 okuno t koutsogiannaki s hou l bu w ohto u eckenhoff rg et al december 2019 volatile anesthetics isoflurane and sevoflurane directly target and attenuate toll like receptor 4 system faseb journal 33 12 14528 41 doi 10 1096 fj 201901570r pmc 6894077 pmid 31675483 sakai em connolly la klauck ja december 2005 inhalation anesthesiology and volatile liquid anesthetics focus on isoflurane desflurane and sevoflurane pharmacotherapy 25 12 1773 88 doi 10 1592 phco 2005 25 12 1773 pmid 16305297 s2cid 40873242 patel ss goa kl april 1996 sevoflurane a review of its pharmacodynamic and pharmacokinetic properties and its clinical use in general anaesthesia drugs 51 4 658 700 doi 10 2165 00003495 199651040 00009 pmid 8706599 s2cid 265731583 paris st cafferkey m tarling m hancock p yate pm flynn pj september 1997 comparison of sevoflurane and halothane for outpatient dental anaesthesia in children british journal of anaesthesia 79 3 280 4 doi 10 1093 bja 79 3 280 pmid 9389840 satuito m tom j 2016 potent inhalational anesthetics for dentistry anesthesia progress 63 1 42 8 quiz 49 doi 10 2344 0003 3006 63 1 42 pmc 4751520 pmid 26866411 common name halothene pdf hazardous substance fact sheet pdf 969 1 1999 via new jersey department of health and senior services halothane niosh pocket guide to chemical hazards niosh national institute for occupational safety and health centers for disease control archived from the original on 8 december 2015 retrieved 3 november 2015 perkins b 7 february 2005 how does anesthesia work scientific american retrieved 30 june 2016 1 2 3 hemmings hc hopkins pm 2006 foundations of anesthesia basic sciences for clinical practice elsevier health sciences pp 292 isbn 978 0 323 03707 5 archived from the original on 30 april 2016 1 2 3 barash p cullen bf stoelting rk cahalan m stock cm ortega r 7 february 2013 clinical anesthesia 7e print ebook with multimedia lippincott williams wilkins pp 116 isbn 978 1 4698 3027 8 archived from the original on 17 june 2016 schüttler j schwilden h 8 january 2008 modern anesthetics springer pp 70 isbn 978 3 540 74806 9 archived from the original on 1 may 2016 bowery ng 19 june 2006 allosteric receptor modulation in drug targeting crc press pp 143 isbn 978 1 4200 1618 5 archived from the original on 10 may 2016 lewis rj 1996 sax s dangerous properties of industrial materials vol 1 3 9th ed new york ny van nostrand reinhold p 1761 us granted 2921098 suckling cw raventos j process for the preparation of 1 1 1 trifluoro 2 bromo 2 chloroethane published 30 june 1958 issued 12 january 1960 assigned to imperial chemical industries halogenated anesthetics livertox clinical and research information on drug induced liver injury national institute of diabetes and digestive and kidney diseases january 2018 pmid 31644158 nbk548851 ma tg ling yh mcclure gd tseng mt october 1990 effects of trifluoroacetic acid a halothane metabolite on c6 glioma cells journal of toxicology and environmental health 31 2 147 158 bibcode 1990jteh 31 147m doi 10 1080 15287399009531444 pmid 2213926 biermann js rice sa fish kj serra mt september 1989 metabolism of halothane in obese fischer 344 rats anesthesiology 71 3 431 7 doi 10 1097 00000542 198909000 00020 pmid 2774271 eger ei 1984 the pharmacology of isoflurane british journal of anaesthesia 56 suppl 1 71s 99s pmid 6391530 mueller lm march 2021 medicating anaesthesiology pharmaceutical change specialisation and healthcare reform in post war britain social history of medicine 34 4 1343 65 doi 10 1093 shm hkaa101 bovill jg 2008 inhalation anaesthesia from diethyl ether to xenon modern anesthetics handbook of experimental pharmacology vol 182 pp 121 142 doi 10 1007 978 3 540 74806 9_6 isbn 978 3 540 72813 9 pmid 18175089 niedermeyer e da silva fh 2005 electroencephalography basic principles clinical applications and related fields lippincott williams wilkins p 1156 isbn 978 0 7817 5126 1 archived from the original on 9 may 2016 himmel hm 2008 mechanisms involved in cardiac sensitization by volatile anesthetics general applicability to halogenated hydrocarbons critical reviews in toxicology 38 9 773 803 doi 10 1080 10408440802237664 pmid 18941968 s2cid 12906139 chavez ca ski cf thompson dr july 2014 psychometric properties of the cardiac depression scale a systematic review heart lung circulation 23 7 610 8 doi 10 1016 j hlc 2014 02 020 pmid 24709392 yentis sm hirsch np ip j 2013 anaesthesia and intensive care a z an encyclopedia of principles and practice 5th ed elsevier health sciences p 264 isbn 978 0 7020 5375 7 archived from the original on 10 september 2017 national formulary of india 4th ed new delhi india indian pharmacopoeia commission 2011 p 411 gelb aw vreede e october 2024 availability of halothane is still important in some parts of the world canadian journal of anaesthesia 71 10 1427 1428 doi 10 1007 s12630 024 02836 9 pmid 39256303 wayback machine pdf wfsahq org archived from the original pdf on 5 september 2024 retrieved 30 november 2025 cite web cite uses generic title help miller al theodore d widrich j 2022 inhalational anesthetic statpearls treasure island fl statpearls publishing pmid 32119427 nbk554540 1 2 hodnebrog ø etminan m fuglestvedt js marston g myhre g nielsen cj et al 24 april 2013 global warming potentials and radiative efficiencies of halocarbons and related compounds a comprehensive review pdf reviews of geophysics 51 2 300 378 bibcode 2013rvgeo 51 300h doi 10 1002 rog 20013 hodnebrog ø aamaas b fuglestvedt js marston g myhre g nielsen cj et al september 2020 updated global warming potentials and radiative efficiencies of halocarbons and other weak atmospheric absorbers reviews of geophysics 58 3 e2019rg000691 bibcode 2020rvgeo 5800691h doi 10 1029 2019rg000691 pmc 7518032 pmid 33015672 vollmer mk rhee ts rigby m hofstetter d hill m schoenenberger f et al 2015 modern inhalation anesthetics potent greenhouse gases in the global atmosphere geophysical research letters 42 5 1606 1611 bibcode 2015georl 42 1606v doi 10 1002 2014gl062785 v t e general anesthetics n01a inhalational chloroform cyclopropane desflurane diethyl ether enflurane ethylene fluroxene halothane isoflurane methoxyflurane methoxypropane nitrous oxide sevoflurane trichloroethylene thiomethoxyflurane vinyl ether xenon injection phenols cipepofol ciprofol fospropofol propofol barbiturates amobarbital hexobarbital methohexital narcobarbital thiamylal thiopental thiotetrabarbital benzodiazepines midazolam diazepam lorazepam remimazolam opioids morphine oxycodone anileridine embutramide fentanyl alfentanil phenoperidine remifentanil sufentanil arylcyclohexylamines esketamine ketamine phencyclidine tiletamine neuroactive steroids alfadolone alfaxalone hydroxydione others etomidate propoxate metomidate propanidid who em withdrawn from market clinical trials phase iii never to phase iii pharmacodynamics v t e gaba a receptor positive modulators alcohols brometone butanol chloralodol chlorobutanol cloretone ethanol alcohol alcoholic drink ethchlorvynol isobutanol isopropanol menthol methanol methylpentynol pentanol petrichloral propanol tert butanol 2m2p tert pentanol 2m2b tribromoethanol trichloroethanol triclofos trifluoroethanol barbiturates dmbb allobarbital alphenal amobarbital aprobarbital barbexaclone barbital benzobarbital benzylbutylbarbiturate brallobarbital brophebarbital butabarbital secbutabarbital butalbital buthalital butobarbital butallylonal carbubarb crotylbarbital cyclobarbital cyclopentobarbital difebarbamate enallylpropymal ethallobarbital eterobarb febarbamate heptabarb heptobarbital hexethal hexobarbital methallatal metharbital methitural methohexital methylphenobarbital narcobarbital nealbarbital pentobarbital phenallymal phenobarbital phetharbital primidone probarbital propallylonal propylbarbital proxibarbital reposal secobarbital sigmodal spirobarbital talbutal tetrabamate tetrabarbital thialbarbital thiamylal thiobarbital thiobutabarbital thiopental thiotetrabarbital valofane vinbarbital vinylbital benzodiazepines 2 oxoquazepam 3 hydroxyphenazepam adinazolam alprazolam arfendazam avizafone bentazepam bretazenil bromazepam bromazolam brotizolam camazepam carburazepam chlordiazepoxide ciclotizolam cinazepam cinolazepam clazolam climazolam clobazam clonazepam clonazolam cloniprazepam clorazepate clotiazepam cloxazolam cp 1414s cyprazepam delorazepam demoxepam diazepam diclazepam dimdazenil doxefazepam elfazepam estazolam ethyl carfluzepate ethyl dirazepate ethyl loflazepate etizolam fg 8205 fletazepam flubromazepam flubromazolam fludiazepam flunitrazepam flunitrazolam flurazepam flutazolam flutemazepam flutoprazepam fosazepam gidazepam halazepam haloxazolam iclazepam imidazenil irazepine ketazolam lofendazam lopirazepam loprazolam lorazepam lormetazepam meclonazepam medazepam menitrazepam metaclazepam mexazolam midazolam motrazepam n desalkylflurazepam nifoxipam nimetazepam nitrazepam nitrazepate nitrazolam nordazepam nortetrazepam oxazepam oxazolam phenazepam pinazepam pivoxazepam prazepam premazepam proflazepam pyrazolam qh ii 66 quazepam reclazepam remimazolam rilmazafone ripazepam ro48 6791 ro48 8684 sh 053 r ch3 2 f sulazepam temazepam tetrazepam tolufazepam triazolam triflubazam triflunordazepam ro5 2904 tuclazepam uldazepam zapizolam zolazepam zomebazam carbamates carisbamate carisoprodol clocental cyclarbamate difebarbamate emylcamate ethinamate febarbamate felbamate hexapropymate hydroxyphenamate lorbamate mebutamate meprobamate nisobamate pentabamate phenprobamate procymate styramate tetrabamate tybamate flavonoids 6 methylapigenin ampelopsin dihydromyricetin apigenin baicalein baicalin catechin egc egcg hispidulin 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Load Info

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load time (s)0.135184
redirect count1
speed download726570
server IP 185.15.58.224
* all occurrences of the string "http://" have been changed to "htt???/"