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ence of an animal to explore another mouse compared with an inanimate object or a novel mouse compared with a familiar one this is taken to be a proxy for social cognition and behavior in people with autism rodents emit usvs in diverse social situations across their lifespan and these are taken to have a communicative function usvs can be assayed in the lab under various conditions and are claimed to be relevant to the core symptoms of communication deficits in human patients one issue with this particular assay is that both increases and decreases in usvs have been interpreted as autistic like behaviors in addition to these behavioral tests a wide range of other assays may also be performed to assess arousal locomotor activity motor coordination anxiety stereotypy learning and memory and other parameters attempts have been made to put the human fecal microbiome into mice and look for effects but 85 of bacterial genera found in the mouse microbiome not present in man a substantial proportion of the species that comprise the human gut microbiome fail to colonize in the recipient animals and that species that do colonize assemble into communities that differ substantially from those found in the human donors there are three seminal papers prominently cited as providing evidence that intervening on the microbiome in mice can either cause or treat autism related behaviors according to google scholar as of may 19th 2025 these are the most highly cited studies in this field with 3 739 1 245 and 1 107 citations respectively 1 paper there is no good evidence that maternal immune activation has any causal involvement in autism etiology a number of studies have found a small increased risk of autism in the offspring of mothers exposed to infections during pregnancy sometimes only when subdividing cohorts by some covariates such as the semester of pregnancy in which the infection occurred the final paper of this set 3 by sharon and colleagues ostensibly offered the most direct test of the causal involvement of the microbiome in autism the authors claimed that colonization of mice with gut microbiota from human donors with asd but not from td controls is sufficient to promote behaviors in mice consistent with the core behavioral features of asd a tiny sample set 8 asd 5 normals pathetic deeper problems with the statistical analyses were discovered post publication in particular the authors had treated each mouse as an independent observation when they should have been treated as experimental replicates of transplants from specific donors to their credit the authors made their primary data and code available for reanalysis when the data were analyzed with the appropriate statistical model the supposedly significant differences disappeared with the exception of marble burying where the remaining effect is statistically significant but very small the main claims of the paper thus rest on flawed analyses and do not stand up to statistical scrutiny what a waste of taxpayer money my comment two human studies of fecal transplants as therapy were large 40 and 49 autistics but the design was open label not randomized controlled trials however one double blind randomized clinical trial of fecal microbiota transplant fmt in children with autism spectrum disorder asd has been reported randomizing 52 to fmt and 51 to placebo the study failed to find any between arm differences in improved clinical symptoms in children across three separate scales srs 2 t score primary abc scores or vineland 3 composite score in an apparently post hoc analysis of outcomes they did observe a significant between arm difference in one domain of the vineland 3 but did not account for multiple tests importantly these authors observed outcome improvements in both arms of the study i e participants in the placebo arm similarly improved to those in the fmt arm and concluded that it is essential to conduct efficacy evaluations in asd research using randomised double blind placebo controlled trials a typical study starts with the notion that there is some link between autism and the microbiome but is vague in terms of the specific hypothesis being tested so that what we see is hypothesizing after results are known harking we note that the gut microbiome has been similarly and equally vaguely linked to the risk of a large number of other conditions including depression anxiety attention deficit hyperactivity disorder adhd obsessive compulsive disorder ocd schizophrenia post traumatic stress disorder ptsd parkinson s disease alzheimer s disease cardiovascular disease obesity eczema asthma arthritis and many others given that the same methods have been used for most of these studies it seems likely that they may suffer from the same methodological shortcomings word to the wise any time you see a paper saying that lab test environmental value life event has been linked to some disease or other ask to see the evidence and examine it carefully all is not lost at least the problem has been recognized and work is being done to clean things up this happened with functional mri and neuropsychiatric disease 10 years ago here are two links https luysii wordpress com 2016 07 17 functional mri research is a scientific sewer https luysii wordpress com 2020 06 07 functional mri research is a scientific sewer take 2 it s hard to believe but most functional mri work back then was being done without knowing whether the subject was awake or asleep it took a lot of work but things have been cleaned up maybe a pony will be found in the roomfull of feces that is research on the microbiome and autism today january 26 2026 9 38 pm categories medicine in general neurology psychiatry post a comment tagged autism and the microbiome autism spectrum disorder and the microbiome dysbiosis failure to account for multiple statistical tests fecal transplants for autism fmri fmri was a scientific sewer functional mri harking hypothesizing after results are known is there a mouse model of autism marble burying replication crisis in autism microbiome research three chamber social approach test for autism tiny sample size lead to fluke conclusions ultrasonic vocalization why you shouldn t believe linked to in a scientific paper why you should go to princeton if they accepted you in a few months it will be 70 years since i entered princeton as a freshman all alumni are asked to interview admission candidates and describe princeton to them i have nothing useful to tell applicants about the current situation at princeton the campus ended at pyne hall back then and class size was just over seven hundred both have doubled in size since 1956 alumni interviewers might still find what follows useful assuming princeton s focus on the undergraduate hasn t changed it would be helpful to show it to very high caliber candidates likely to be deciding on princeton vs other ivies feel free to share this with them or anyone else back then freshmen premeds took physics not honors physics not physics for poets the prof was a mild mannered man who wore a jacket and tie and could have been a shoe salesman or so i thought until he brought in his friend and colleague neils bohr to speak to us bohr was old and weak and had only a few years to live but he sat in a chair and mumbled to us in what appeared to be danish this fall it will be 70 years but i can still see him the physics prof was john wheeler he of the black hole and wormholes teacher of feynman etc etc and this was why princeton was such a great place for undergraduates they didn t hide their best and made sure they taught undergraduates hopefully it is the same now similarly the exposure to my undergraduate chemistry advisor paul schleyer princeton 52 was intense and formative here s what it was like he was a marvelous undergraduate advisor only 7 years out from his own princeton degree when we first came in contact with him and a formidable physical and intellectual presence even then his favorite opera recording which he somehow found a way to get into the lab was don giovanni s scream as he realized he was to descend into hell i never had the courage to ask him if the scars on his face were from dueling we d work late in the lab then go out for pizza in later years i ran into a few merck chemists who found him a marvelous consultant however back in the 50 s we d be working late and he d make some crack about industrial chemists being at home while we were working the high point of their day being mowing their lawn i d say the intense interaction with faculty was typical back then hopefully it is the same now so i switched to chemistry and in the fall of 1960 i was off to chemistry graduate school at harvard which schleyer called mecca the department was terrific and i personally interacted with 7 guys doing the work which would later win them the nobel in chemistry woodward corey lipscomb gilbert hoffman bloch and karplus to my knowledge the only one teaching undergraduates was konrad bloch so who was teaching harvard undergraduates none other than yours truly 2 years further along in organic chemistry than they were spending 6 8 hours a week with them as a teaching assistant in orgo lab compared to what i d received i felt they were being cheated hopefully things are the same at princeton now they certainly were 10 years later tony zee 66 friend and physics prof at uc santa barbara heard about a future physics nobel in the monthly undergraduate physics major evening get together by the faculty member who did the work luysii princeton 60 january 17 2026 11 53 am categories chemistry relatively pure social issues be civil post a comment tagged john wheeler neils bohr paul schleyer princeton 52 princeton vs harvard for undergraduate teaching richard feynman tony zee princeton 66 woodward corey lipscomb hoffman gilbert bloch and karplus bari weiss takes staff of 60 minutes back to journalism school one son majored in journalism at the university of minnesota although he never wrote for a newspaper or tv he found what he learned focus on the important be brief be clear get the facts straight useful in whatever he did microsoft vh1 mtv mfa at usc in animation teaching it in hong kong and taiwan etc etc so it was particularly interesting to read bari weiss s reasoning as to why she cut a 60 minutes program 2 days ago basically she listed the reasons the program was journalistically incompetent and effectively sent its creators back to journalism school here is an exact copy of what she wrote to them my comments are interspersed in bold hi all i m writing with specific guidance on what i d like for us to do to advance the cecot story about the horrific prison conditions in san salvidor the us sent venezuelans i know you d all like to see this run as soon as possible i feel the same way but if we run the piece as is we d be doing our viewers a disservice last month many outlets most notably the new york times exposed the horrific conditions at cecot our story presents more of these powerful testimonies and putting those accounts into the public record is valuable in and of itself but if we re going to run another story about a topic that has by now been much covered we need to advance it you re beating a dead horse and adding nothing new among the ways to do so does anyone in the administration or anyone prominent who defended the use of the alien enemies act now regret it in light of what these venezuelans endured at cecot that s a question i d like to see asked and answered here s one thing you should have done but didn t do at present we do not present the administration s argument for why it sent 252 venezuelans to cecot did you ask or did you decide it was beneath contempt what we have is karoline leavitt s soundbite claiming they are evildoers in america rapists murderers etc but isn t there much more to ask in light of the torture that we are revealing tom homan and stephen miller don t tend to be shy i realize we ve emailed the dhs spox but we need to push much harder to get these principals on the record the data we present paints an incongruent picture of the 252 venezuelans sent to cecot we say nearly half have no criminal histories an example of antiadministration framing which is why few believe 60 minutes and the legacy press in general in other words more than half do have criminal histories we should spend a beat explaining this why didn t you we then say that only 8 of the 252 have been sentenced in america for violent offenses but what about charged my point is that we should include as much as we can possibly know and understand about these individuals secretary noem s trip to cecot we report that she took pictures and video there with ms 13 gang members not tda members with no comment from her or her staff about what her goal on that trip was or what she saw there or if she had or has concerns about the treatment of detainees like the ones in our piece you didn t even ask hard questions to noem or the administration i also think that the ensuing analysis from the berkeley students is strange the pictures are alarming we should include them but what does the analysis add we need to do a better job of explaining the legal rationale by which the administration detained and deported these 252 venezuelans to cecot it s not as simple as trump invoking the alien enemies act and being able to deport them immediately and that isn t the administration s argument the admin has argued in court that detainees are due judicial review and we should explain this with a voice arguing that trump is exceeding his authority under the relevant statute and another arguing that he s operating within the bounds of his authority again something you should have reported on but didn t there s a genuine debate here if we cut down kristi noem analysis we d have the time my general view here is that we do our viewers the best service by presenting them with the full context they need to assess the story in other words i believe we need to do more reporting here i am eager and available to help i tracked down cell numbers for homan and miller and sent those along please let me know how i can support you even though you belong back in journalism school yours ba i ve never liked 60 minutes and purely for medical reasons back when i was a practicing clinical neurologist 72 00 they were a fount of medical misinformation i spent a fair of time cleaning up after the elephants particularly loathsome was the time they argued that mercury in fillings caused multiple sclerosis they said it once it took me multiple one on ones with my frightened ms patients to try to clear things up december 23 2025 3 38 pm categories social issues be civil post a comment tagged 60 minutes staff sent back to journalism school bari weiss cecot journalism school mercury in fillings does not cause multiple sclerosis venezuelans in san salvador prisons older posts recent posts where is climate of hate when you...
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