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ion from intraluminal injurious factors such as gastric acid bile acids pepsin and trypsin and from physical chemical and bacterial agents 42 stomach as nutrition sensor the human stomach has receptors responsive to sodium glutamate 43 and this information is passed to the lateral hypothalamus and limbic system in the brain as a palatability signal through the vagus nerve 44 the stomach can also sense independently of tongue and oral taste receptors glucose 45 carbohydrates 46 proteins 46 and fats 47 this allows the brain to link nutritional value of foods to their tastes 45 thyrogastric syndrome this syndrome defines the association between thyroid disease and chronic gastritis which was first described in the 1960s 48 this term was coined also to indicate the presence of thyroid autoantibodies or autoimmune thyroid disease in patients with pernicious anemia a late clinical stage of atrophic gastritis 49 in 1993 a more complete investigation on the stomach and thyroid was published 50 reporting that the thyroid is embryogenetically and phylogenetically derived from a primitive stomach and that the thyroid cells such as primitive gastroenteric cells migrated and specialized in uptake of iodide and in storage and elaboration of iodine compounds during vertebrate evolution in fact the stomach and thyroid share iodine concentrating ability and many morphological and functional similarities such as cell polarity and apical microvilli similar organ specific antigens and associated autoimmune diseases secretion of glycoproteins thyroglobulin and mucin and peptide hormones the digesting and readsorbing ability and lastly similar ability to form iodotyrosines by peroxidase activity where iodide acts as an electron donor in the presence of h 2 o 2 in the following years many researchers published reviews about this syndrome 51 clinical significance edit an endoscopy of a normal stomach of a healthy 65 year old woman endoscopic image of a fundic gland polyp diseases edit main article stomach disease a series of radiographs can be used to examine the stomach for various disorders this will often include the use of a barium swallow another method of examination of the stomach is the use of an endoscope a gastric emptying study is considered the gold standard to assess the gastric emptying rate 52 a large number of studies have indicated that most cases of peptic ulcers and gastritis in humans are caused by helicobacter pylori infection and an association has been seen with the development of stomach cancer 53 a stomach rumble is actually noise from the intestines surgery edit in humans many bariatric surgery procedures involve the stomach in order to lose weight a gastric band may be placed around the cardia area which can adjust to limit intake the anatomy of the stomach may be modified or the stomach may be bypassed entirely surgical removal of the stomach is called a gastrectomy and removal of the cardia area is a called a cardiectomy cardiectomy is a term that is also used to describe the removal of the heart 54 55 56 a gastrectomy may be carried out because of gastric cancer or severe perforation of the stomach wall fundoplication is stomach surgery in which the fundus is wrapped around the lower esophagus and stitched into place it is used to treat gastroesophageal reflux disease gerd 57 etymology edit the word stomach is derived from greek stomachos στόμαχος ultimately from stoma στόμα mouth 58 gastro and gastric meaning related to the stomach are both derived from greek gaster γαστήρ belly 59 60 61 other animals edit although the precise shape and size of the stomach varies widely among different vertebrates the relative positions of the esophageal and duodenal openings remain relatively constant as a result the organ always curves somewhat to the left before curving back to meet the pyloric sphincter however lampreys hagfishes chimaeras lungfishes and some teleost fish have no stomach at all with the esophagus opening directly into the intestine these animals all consume diets that require little storage of food no predigestion with gastric juices or both 62 comparison of stomach glandular regions from several mammalian species frequency of glands may vary more smoothly between regions than is diagrammed here asterisk ruminant represents the omasum which is absent in tylopoda tylopoda also have some cardiac glands opening onto ventral reticulum and rumen 63 many other variations exist among the mammals 64 65 yellow esophagus green esophageal nonglandular region 66 purple cardiac gland region 66 red fundic gland region 66 blue pyloric gland region 66 dark blue duodenum the gastric lining is usually divided into two regions an anterior portion lined by fundic glands and a posterior portion lined with pyloric glands cardiac glands are unique to mammals and even then are absent in a number of species the distributions of these glands vary between species and do not always correspond with the same regions as in humans furthermore in many non human mammals a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the esophagus ruminants in particular have a complex four chambered stomach the first three chambers rumen reticulum and omasum are all lined with esophageal mucosa 62 while the final chamber functions like a monogastric stomach which is called the abomasum in birds and crocodilians the stomach is divided into two regions anteriorly is a narrow tubular region the proventriculus lined by fundic glands and connecting the true stomach to the crop beyond lies the powerful muscular gizzard lined by pyloric glands and in some species containing stones that the animal swallows to help grind up food 62 in insects there is also a crop the insect stomach is called the midgut information about the stomach in echinoderms or molluscs can be found under the respective articles additional images edit image showing the celiac artery and its branches a human stomach at autopsy showing the many folds rugae high quality image of the stomach see also edit wikimedia commons has media related to stomach gastroesophageal reflux disease gastric microbiota proton pump inhibitor references edit nosek thomas m section 6 6ch2 s6ch2_30 essentials of human physiology archived from the original on 2016 03 24 the stomach at the anatomy lesson by wesley norman georgetown university definition of gastric www merriam webster com 12 may 2025 retrieved 13 may 2025 1 2 3 4 5 chaurasia b d 2013 19 human anatomy vol 2 6th ed 4819 xi prahlad street ansari road daryaganj new delhi 110002 india cbs publishers and distributors pp 250 252 isbn 978 81 239 2331 4 cite book cs1 maint location link sherwood lauralee 1997 human physiology from cells to systems belmont ca wadsworth pub co isbn 978 0 314 09245 8 oclc 35270048 wenzel v idris ah banner mj kubilis ps band r williams jl et al 1998 respiratory system compliance decreases after cardiopulmonary resuscitation 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