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about partners news twitter events publications featured marjo den broeder juliette legler eurion cluster contact menu about partners news events publications featured eurion cluster contact beating goliath the incidence of obesity and metabolic disorders such as diabetes and non alcoholic fatty liver disease has reached goliathan proportions there is strong evidence that exposures to chemicals present in our environment contribute to these diseases this project aims to beat goliath by better understanding how these chemicals work and developing new methods to test chemicals for metabolism disrupting effects what are metabolism disrupting chemicals mdcs are natural or anthropogenic chemicals that that have the ability to promote metabolic changes that can ultimately result in obesity diabetes and or fatty liver in humans four main targets tissues of mdcs will be studied in goliath namely adipose tissue liver pancreas and muscle towards an integrated approach to testing and assessment of mdcs currently there are no regulatory tests to assess how and to what extent chemicals disrupt metabolism leading to metabolic disorders by developing and combining data from in silico and in vitro assays animal and human studies the aim of goliath is to develop an integrated internationally harmonised approach for testing and assessment partners in goliath goliath is an international consortium consisting of 15 partners from 8 european countries and the united states news final stakeholder seminar goliath and athena our final seminar international initiatives to develop methods for the identification of metabolism and thyroid hormone system disruption chemicals will be held online and on site on tuesday 10 december 2024 from 14 17 cet the seminar will include highlights and key messages from both the goliath and athena projects and will feature insights from different stakeholders read more eurion presented at the 6th annual edc forum read more setac 2021 read more 3rd progress meeting goliath virtual read more goliath 2nd progress meeting paris read more goliath 1st progress meeting read more goliath presented at setac helsinki read more goliath kick off meeting read more more news events goliath utrecht university institute for risk assessment sciences yalelaan 104 3584 cm utrecht the netherlands this project has received funding from the european union s horizon 2020 research and innovation programme under grant agreement no 825489 this output reflects the views only of the author s and the european union cannot be held responsible for any use which may be made of the information contained therein online