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se to tryptophol 68 serotonin precursor edit tryptophan affects brain serotonin synthesis when given orally in a purified form and is used to modify serotonin levels for research 30 low brain serotonin level is induced by administration of tryptophan poor protein in a technique called acute tryptophan depletion 69 studies using this method have evaluated the effect of serotonin on mood and social behavior finding that serotonin reduces aggression and increases agreeableness 70 psychedelic effects edit see also 5 hydroxytryptophan psychedelic effects tryptophan produces the head twitch response htr in rodents when administered at sufficiently high doses 71 the htr is induced by serotonergic psychedelics like lysergic acid diethylamide lsd and psilocybin and is a behavioral proxy of psychedelic effects 72 73 tryptophan is converted into the trace amine tryptamine and tryptamine is n methylated by indolethylamine n methyltransferase inmt into n methyltryptamine nmt and n n dimethyltryptamine dmt which are known serotonergic psychedelics 71 74 75 76 77 78 fluorescence edit main article fluorescence spectroscopy tryptophan fluorescence tryptophan is an important intrinsic fluorescent probe amino acid which can be used to estimate the nature of the microenvironment around the tryptophan residue most of the intrinsic fluorescence emissions of a folded protein are due to excitation of tryptophan residues see also edit 5 hydroxytryptophan 5 htp α methyltryptophan acree rosenheim reaction adamkiewicz reaction attenuator genetics dimethyltryptamine dmt hopkins cole reaction serotonin tryptamine references edit 1 2 görbitz ch törnroos kw day gm 2012 single crystal investigation of l tryptophan with z 16 acta crystallographica section b 68 pt 5 549 557 doi 10 1107 s0108768112033484 pmid 22992800 dawson rm et al 1969 data for biochemical research oxford clarendon press isbn 0 19 855338 2 nomenclature and symbolism for amino acids and peptides iupac iub joint 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