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mbers to contribute solutions for general usage questions or suggestions we recommend starting a discussion in the tool s github repository this approach broadens visibility encourages collaboration and lets maintainers convert your post into an issue if needed if you are a rosetta commons member with slack access you can also use the tool s dedicated channel or the how_do_i_do_x channel to get help and feedback actively supported software tools expand rosetta a c software suite for modeling macromolecular structures about rosetta rosetta is software suite for modeling macromolecular structures its functionalities include structure prediction design and remodeling of proteins and nucleic acids license information for non commercial users academic non profits government rosetta is available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing see our licensing faq for more information documentation rosetta documentation download installation release versions precompiled binaries and source development version build from source related links docker image rosie historical rosetta forum have a question about rosetta or pyrosetta check the rosetta forum first the rosetta forum officially closed in mid 2024 but remains available in a read only format it still contains helpful answers to many user questions and is an excellent resource for rosetta developers and users the best way to search the forum is by using google s site operator in google put site forum rosettacommons org before your search terms expand pyrosetta a python based interface for the rosetta software suite about pyrosetta pyrosetta is a python based interface to the rosetta molecular modeling suite it enables the user to use python scripting to build powerful custom modeling algorithms license information for non commercial users academic non profits government pyrosetta is available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing documentation pyrosetta documentation download installation installation guide related links docker image rosie historical rosetta forum have a question about rosetta or pyrosetta check the rosetta forum first the rosetta forum officially closed in mid 2024 but remains available in a read only format it still contains helpful answers to many user questions and is an excellent resource for rosetta developers and users the best way to search the forum is by using google s site operator in google put site forum rosettacommons org before your search terms expand foldit a crowdsourcing computer game for contributing to scientific research about foldit foldit is a revolutionary crowdsourcing computer game enabling you to contribute to scientific research license information the foldit game is free to play you can sign up for an account here documentation about foldit download installation quickstart guide expand rfdpoly de novo design of dna rna proteins and mixed assemblies about rfdpoly rfdpoly is a backbone generation tool for de novo design of dna rna proteins and mixed assemblies license information licensed under a bsd license more information can be found here documentation rfdpoly documentation download installation installation guide note installation assumes use of apptainer expand rf3 an all atom structure prediction tool that is part of foundry about rf3 rf3 rosettafold3 is part of foundry and is an all atom structure prediction tool with implicit chirality representations and atom level geometric conditioning license information licensed under a bsd3 clause license more information can be found here documentation rf3 documentation download installation installation guide related links foundry docker image expand mpnn a protein sequence design tool that is part of foundry about mpnn mpnn is part of foundry and is a combination of ligand protein and soluble mpnn that allows you to design protein sequences that are ligand aware or find soluble analogs of membrane proteins license information licensed under a bsd3 clause license more information can be found here documentation mpnn documentation download installation installation guide related links foundry docker image expand hbdesigner an algorithm that designs highly connected hydrogen bonding networks about hbdesigner hbdesigner is an algorithm that designs highly connected hydrogen bonding networks that fit the requested design constraints onto an input protein backbone license information licensed under an mit license more information can be found here documentation hbdesigner documentation download installation installation guide common installation issues some active support for software tools expand rfdiffusion3 atom level protein backbone generation and sequence design about rfdiffusion3 rfdiffusion3 is for atom level protein backbone generation and sequence design license information licensed under a bsd3 clause license more information can be found here documentation rfdiffusion3 documentation download installation installation guide installation on unix systems related links foundry docker image expand rfdiffusion2 ligand aware backbone generation specifically for enzyme design about rfdiffusion2 rfdiffusion2 is for ligand aware backbone generation specifically created to help with enzyme design license information licensed under a bsd3 clause license more information can be found here documentation rfdiffusion2 documentation download installation installation guide expand rfdiffusion an open source method for backbone structure generation about rfdiffusion rfdiffusion is an open source method for backbone structure generation license information for non commercial users academic non profits government all rosettadl tools are available for free under a license that can be found here documentation rfdiffusion documentation download installation installation guide related links docker image expand rosettafold a deep learning protein folding package about rosettafold rosettafold is a deep learning protein folding package license information rosettafold is part of the rosetta dl bundle of deep learning packages for non commercial users academic non profits government all rosettadl tools are available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing download installation build from source related links robetta server expand proteingenerator generator for sequence structure pairs using rosettafold about proteingenerator proteingenerator is a generator for sequence structure pairs using rosettafold license information licensed under an mit license more information can be found here download installation getting started guide expand deepab a deep learning tool for antibody structure prediction about deepab deepab is a deep learning tool for antibody structure prediction license information deepab is part of the rosetta dl bundle of deep learning packages for non commercial users academic non profits government all rosettadl tools are available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing download installation installation guide expand fvhallucinator a tool for designing sequences that fold into fv structures using deepab about fvhallucinator fvhallucinator is a tool for designing sequences that fold into a desired fv structure using deepab license information fvhallucinator is part of the rosetta dl bundle of deep learning packages for non commercial users academic non profits government all rosettadl tools are available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing download installation installation guide expand masif a tool for deciphering patterns in molecular surfaces about masif masif or molecular surface interaction fingerprints is a tool for deciphering patterns in molecular surfaces license information masif is part of the rosetta dl bundle of deep learning packages for non commercial users academic non profits government all rosettadl tools are available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing download installation installation guide expand protein seq des a tool for protein sequence design from a learned potential about protein seq des protein seq des is a tool for protein sequence design from a learned potential license information protein seq des is part of the rosetta dl bundle of deep learning packages for non commercial users academic non profits government all rosettadl tools are available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing download installation installation guide expand af2 peptide hallucination generator for binders to flexible peptides using alphafold2 about af2 peptide hallucination af2 peptide hallucination is a generator for binders to flexible peptides using alphafold2 license information licensed under a bsd license more information can be found here download installation installation guide expand rfantibody structure based de novo antibody design about rfantibody rfantibody is a tool for structure based de novo antibody design license information licensed under an mit license more information can be found here download installation installation guide historical software tools no active support expand trrosetta2 a repository for deep learning models developed in the rosetta community about trrosetta2 trrosetta2 is a repository for publicly available deep learning models developed in the rosetta community license information trrosetta2 is part of the rosetta dl bundle of deep learning packages for non commercial users academic non profits government all rosettadl tools are available for free under a license that can be found here a paid license is required for commercial users and can be acquired through the university of washington s comotion office licensing revenue supports the rosetta commons research community by funding conferences workshops summer interns and post baccalaureate scholars mini grants user support documentation and code infrastructure and testing download installation installation guide expand privileged residues methods for placing residues on the surface of a target protein about privileged residues privileged residues are methods for placing residues on the surface of a target protein that can be added to rifdock license information licensed under an apache software license more information can be found here documentation privileged residues documentation download installation installation guide expand rfdesign protein hallucination and inpainting with rosettafold about rfdesign rfdesign is a tool for protein hallucination and inpainting with rosettafold deprecated by rfdiffusion license information licensed under a bsd license more information can be found here download installation installation guide expand bcl with rosetta integration a package with biological and chemical research tools about bcl with rosetta integration bcl with rosetta integration is an open source package containing tools for biological and chemical research license information licensed under an mit license more information can be found here download installation installation guides expand fork for alphafold alphafold v2 0 and alphafold multimer implementation tool about fork for alphafold fork for alphafold is an implementation of the inference pipeline of alphafold v2 0 and alphafold multimer license information licensed under an apache software license more information can be found here download installation installation guide expand fork for autorotlib a tool for parameterizing non cannonical amino acids about fork for autorotlib fork for autorotlib is a tool for parameterizing non cannonical amino acids license information openeye license required learn more here download installation usage guide expand jade2 a repository for modules and applications for the design of biological molecules about jade2 jade2 is a repository for modules and applications to aid in the design and analysis of biological molecules license information licensed under a bsd clause 2 license more information can be found here download installation setup instructions expand abexpress a collection of scripts for training and predicting antibody expressability about abexpress abexpress is a collection of scripts for training and predicting antibody expressability license information licensed under an mit license more information can be found here download installation installation guide contact us code of conduct 2026 rosetta commons all rights reserved opens in new tab opens in new tab opens in new tab opens in new tab opens in new tab manage consent to provide the best experiences we use technologies like cookies to store and or access device information 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