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rtery spasm and cardiomyocyte death finally the main cardiovascular risks are explained within the proposed framework read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories atherosclerosis cardiac ischemia cardiovascular disease coronary artery disease dyslipidemia heart attack hypertension myocardial infarction vascular disease metastatic pattern of breast cancer by histologic grade a seer population based study author s chaowei gao jiangen wang peisheng he xin xiong specialty surgery oncology institution department of breast surgery chongqing university three gorges hospital address chongqing 404100 china published on december 27 2022 abstract population based estimates of the differences in metastatic pattern incidence and prognosis of breast cancer patients by histologic grade at breast cancer diagnosis are lacking patients with breast cancer and metastases at the time of diagnosis were identified using the surveillance epidemiology and end results seer database multivariable logistic and cox regression were performed to determine the effect of histologic grade on the presence of metastases at diagnosis and all cause mortality we identified a population based sample of adult patients diagnosed with invasive breast cancer between 2010 and 2015 for whom the presence or absence of metastases was known we depicted the landscape of metastatic pattern of breast cancer histologic grade that the percentage of bone metastasis was decreasing with higher histologic grade while the percentages of lung and brain metastasis were increasing higher histologic grade was associated with a greater incidence of all metastatic lesions median durations of survival with distant metastasis were 41 months grade i 34 months grade ii 21 months grade iii 13 months grade iv and 16 months unknown histologic grade grade iii and unknown histologic grade represent the most common part of patients with metastatic disease but not for breast cancer patients without metastasis in multivariate analysis grade ii iii iv and unknown histologic grade were associated with significantly greater odds of patients with metastatic disease to any distant site compared with grade i but not to bone grade iii was associated with increased all cause mortality among patients having metastases to any sites bone brain liver and lung compared with grade i but not grade ii and grade iv breast cancer histologic grades are associated with distinct patterns of metastatic spread and notable differences in survival read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories bone metastasis breast cancer cancer metastasis liver metastasis lung metastasis mechanisms and clinical perspectives of covid 19 induced cardiovascular disease author s antonio vitiello francesco ferrara andrea zovi specialty pharmacology cardiology immunology infectious diseases institution clinical pharmacologist ministry of health of italy address rome 00144 italy published on december 19 2022 abstract covid 19 infection can cause damage to various systems such as cardiovascular respiratory and neurological both during the course of the disease and in the period after recovery caused by the effects of so called long covid cardiovascular complications caused by covid 19 infection are not yet fully understood and characterized cardiovascular complications caused by covid 19 include pericarditis myocarditis dysrhythmias ischemic and non ischemic heart disease and thromboembolic disease the pathophysiological and molecular mechanisms of cardiovascular damage caused by sars cov 2 are still being studied more severe covid 19 cases with the multisystem inflammatory syndrome mis have frequent involvement of cardiovascular damage in addition recent evidence shows that months later individuals who have had a covid 19 infection may be at a greater risk of suffering heart disease than individuals who have not had the infection in this brief literature review we summarize the current evidence in the literature on cardiovascular damage caused by covid 19 during the period of infection and in the long covid and possible concomitant risk factors which may play an important role read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories covid 19 cardiovascular disease coronavirus hypertension myocarditis pericarditis sars cov 2 the independent association between age and serum cholesterol levels in patients with familial hypercholesterolemia author s jinchun he yan wu yaodong wang specialty rheumatology immunology institution department of laboratory medicine the first hospital of lanzhou university lanzhou university address lanzhou gansu 730000 china published on december 16 2022 abstract background studies have suggested that age and the serum total cholesterol tc concentration are independent risk factors for cardiovascular disease cvd in patients with familial hypercholesterolemia fh however the relationship between age and tc in patients with fh is unclear we aimed to investigate the correlation between age and tc in patients with fh methods in this study 103 patients with fh and 106 non fh controls were recruited from 2004 to 2017 spearman and partial correlation analyses as well as multiple regression analyses were used to evaluate the relationship between tc and age results there were no significant differences in age gender or bmi between the fh group and the control group p 0 05 family history of cvd tc low density lipoprotein cholesterol ldl c high density lipoprotein cholesterol hdl c lipoprotein a lp a and non hdl c levels were significantly higher in patients with fh compared with the controls p 0 01 additionally the serum tc levels for ages 50 years were significantly higher than those for ages 50 years p 0 05 in fh patients in both spearman and partial correlation analyses age was found to be significantly correlated with serum tc p 0 001 in the fh group but not in the control group which was confirmed by further multiple linear regression analyses and logistic regression analyses conclusions age is an independent factor influencing serum tc level in patients with fh and it is necessary to conduct early screening and early intervention read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories cardiovascular disease coronary artery disease hypercholesterolemia hypertension nonhematological manifestations of pernicious anemia author s thein h oo specialty hematology medical oncology internal medicine institution section of thrombosis benign hematology the university of texas m d anderson cancer center address 1515 holcombe blvd houston texas 77030 united states published on december 8 2022 abstract pernicious anemia pa is an autoimmune disease characterized by cobalamin deficiency cd due to immune mediated chronic atrophic gastritis cag cd results from poor absorption of dietary cobalamin from the terminal ileum triggered by positive intrinsic factor if antibodies it is the most common cause of cd worldwide despite advances in understanding biochemistry and pathogenesis of pa its diagnosis can be extremely challenging as the disease may present with hematological as well as nonhematological manifestations and also because of unreliable serum cobalamin assays nonhematological manifestations may present in a patient with pa even in the absence of hematological findings herein an overview of common and uncommon nonhematological manifestations of pa is discussed read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories anemia chronic atrophic gastritis gastritis hematology pernicious anemia aggressive and drug resistant pancreatic cancer challenges and novel treatment approaches author s mohamed abbas mohammed alqahtani mohammad y alshahrani khulud alabdullh specialty molecular engineering radiology biophysics physiology institution electrical engineering department college of engineering king khalid university address abha 61421 saudi arabia published on december 7 2022 abstract pancreatic cancer especially pancreatic ductal adenocarcinoma pdac has a mortality rate that is among the highest the single therapy option that has the potential to be curative for the illness is surgery which is generally accepted as being the only effective treatment available this is because most pancreatic tumors are intractable to chemotherapy because of the severe nature of the illness that these tumors cause only around twenty percent of these tumors can be surgically removed when the first symptoms appear this is due to the harm that these tumors cause since surgery in late stage cases does not usually offer benefits here we shed light on the molecular mechanisms of the most aggressive pancreatic tumors that are highly resistant to drugs we also describe two latest novel treatment approaches that are used to combat this fierce tumor targeting exosome mediated tumor enhancement mechanisms and radiation therapy in combination with adverse effect mitigating agents effective treatments for pancreatic cancer are needed to meet this urgent medical need read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories cancer drug resistance cancer metastasis pancreatic cancer tags exosome vaccination reduces risk of alzheimer s disease parkinson s disease and other neurodegenerative disorders author s steven lehrer peter h rheinstein specialty radiation oncology institution department of radiation oncology icahn school of medicine at mount sinai address 1 gustave l levy place new york new york 10029 united states published on october 28 2022 abstract neurodegeneration is an increasing problem of aging alzheimer s disease ad and parkinson s disease pd are the most frequent forms of age related neurodegeneration infectious diseases in general confer a risk of ad influenza and pneumonia vaccinations reduce risk of ad being vaccinated against pneumonia between ages 65 75 is associated with a reduction in the risk of ad afterwards protection against bacterial and viral infection is beneficial to the brain since these infections may activate dormant herpes simplex type 1 hsv 1 and herpes zoster virus hzv hsv 1 and hzv may interact to trigger ad shingles hzv vaccine zostavax reduces risk of ad and pd this finding is consistent with the link between viruses and neurodegeneration herpes virus induced reactivation of embryologic pathways silenced at birth could be one of the pathologic processes in ad and pd once embryologic reactivation has occurred in the brain of an older person and ad or pd develops this complex process relentlessly destroys the protective mechanism it created in utero unanswered question are the ad risk reducing effects of flu pneumonia and shingles vaccinations cumulative read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories alzheimer s disease dementia herpes simplex virus infection herpes zoster influenza lewy body disorders neurodegenerative disease parkinson s disease parp1 is upregulated by hyperglycemia via n6 methyladenosine modification and promotes diabetic retinopathy author s jinghui sun guodong liu rui chen jibin zhou ting chen yalan cheng qiyang lou hao wang specialty ophthalmology institution department of ophthalmology shanghai tenth people s hospital tongji university school of medicine address shanghai 200072 china published on october 28 2022 abstract poly adp ribose polymerase 1 parp1 plays an irreplaceablerole in the progression of diabetic retinopathy dr the m6a methylation in mrna controls gene expression under various physiological and pathological conditions however effects of m6a methylation on parp1 expression and dr progression at molecular level have not been documented this study shows that the levels of parp1 inflammatory factors and fibrosis markers were significantly upregulated via evaluation by real time pcr western blotting and immunofluorescence in both in vivo and in vitro experiments edu cck8 and apoptosis assays demonstrate that knockdown of parp1 not only significantly improved the vitality of hrmecs human retinal microvascular endothelial cells even under high glucose conditions but also prevented glucose induced inflammation fibrosis and angiogenesis in vivo mechanistically dot blot rna pull down and immunoblots were implemented to explore the mechanism of m6a mediated parp1 stability and function parp1 is identified as a target of ythdf2 mediated m6a modification overexpression of ythdf2 substantially suppressed parp1 mrna m6a modification and inhibited its mrna expression collectively it has been demonstrated that parp1 is frequently upregulated in human retinas and contributes to dr progression and that ythdf2 mediated m6a modification epigenetically regulates diabetes induced parp1 expression findings from this work may engender therapeutic targets for treating diabetic retinopathy read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories diabetes diabetic nephropathy type 1 diabetes type 2 diabetes tags angiogenesis immunotherapy for sepsis induced by infections clinical evidence and potential targets author s sheng jie huang juan wang jin long wang specialty internal medicine institution emergency department fuling central hospital address chongqing china published on october 27 2022 abstract sepsis is a life threatening organ dysfunction caused by the maladjustment of the body s response to infection abnormal immune response plays an important role in the progression of sepsis and immunomodulatory therapy is a promising therapeutic strategy for sepsis great efforts have been made recently to elucidate the mechanism by which immune dysfunction contributes to sepsis and identify potential biomarkers and targets for the diagnosis and therapy of sepsis induced by emerging pathogens especially for severe acute respiratory syndrome coronavirus 2 sars cov 2 that causes covid 19 in this review we summarize recent progress on the understanding of immune dysregulation involved in sepsis and highlight potential biomarkers and targets to evaluate immune status of the patients with sepsis for individualized and precise immunotherapy read more access this pdf as a subscriber nbsp nbsp nbsp nbsp related articles categories covid 19 cell mediated immunity immunomodulatory therapy immunotherapy sepsis septic shock stem cell therapy 1 2 3 4 5 6 7 8 9 10 older entries search search tips help journal issues current archive part vol 34 no 173 dec 2022 no 172 oct 2022 no 171 aug 2022 no 170 jun 2022 no 169 apr 2022 no 168 feb 2022 no 167 dec 2021 no 166 oct 2021 no 165 aug 2021 no 164 jun 2021 no 163 apr 2021 no 162 feb 2021 no 161 dec 2020 no 160 oct 2020 no 159 aug 2020 no 158 jun 2020 no 157 apr 2020 no 156 feb 2020 no 155 dec 2019 no 154 oct 2019 no 153 sep 2019 no 152 aug 2019 no 151 jul 2019 no 150 jun 2019 global categories medica...