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s of pkmζ elife 2016 may 17 5 pii e14846 doi 10 7554 elife 14846 compensation of pkmζ in long term potentiation and spatial long term memory in mutant mice tsokas p 1 2 hsieh c 1 yao y 1 lesburguères e 3 wallace ej 1 tcherepanov a 1 jothianandan d 1 hartley br 1 pan l 1 rivard b 1 farese rv 4 sajan mp 4 bergold pj 1 hernández ai 5 cottrell je 2 shouval hz 6 fenton aa 1 3 sacktor tc 1 2 7 1 department of physiology and pharmacology the robert f furchgott center for neural and behavioral science state university of new york downstate medical center brooklyn united states 2 department of anesthesiology state university of new york downstate medical center brooklyn united states 3 center for neural science new york university new york united states 4 department of internal medicine james a haley veterans hospital university of south florida tampa united states 5 department of pathology state university of new york downstate medical center brooklyn united states 6 department of neurobiology and anatomy university of texas medical school at houston houston united states 7 department of neurology state university of new york downstate medical center brooklyn united states leave a comment filed under ageing genetics gerontology memory pkmζ tagged as ageing aging gerontology memory pkmζ april 16 2016 3 13 pm screening for anti aging molecules there is a recent review paper about screening for anti aging molecules finding ponce de leon s pill challenges in screening for anti aging molecules surinder kumar and david lombard aging is characterized by the progressive accumulation of degenerative changes culminating in impaired function and increased probability of death it is the major risk factor for many human pathologies including cancer type 2 diabetes and cardiovascular and neurodegenerative diseases and consequently exerts an enormous social and economic toll the major goal of aging research is to develop interventions that can delay the onset of multiple age related diseases and prolong healthy lifespan healthspan the observation that enhanced longevity and health can be achieved in model organisms by dietary restriction or simple genetic manipulations has prompted the hunt for chemical compounds that can increase lifespan most of the pathways that modulate the rate of aging in mammals have homologs in yeast flies and worms suggesting that initial screening to identify such pharmacological interventions may be possible using invertebrate models in recent years several compounds have been identified that can extend lifespan in invertebrates and even in rodents here we summarize the strategies employed and the progress made in identifying compounds capable of extending lifespan in organisms ranging from invertebrates to mice and discuss the formidable challenges in translating this work to human therapies leave a comment filed under ageing aging anti ageing anti aging science tagged as ageing aging anti ageing anti aging science screening march 31 2016 11 16 pm early onset alzheimer disease revisited there is a recent review revisiting the molecular genetics of early onset alzheimer disease abstract as the discovery of the alzheimer disease ad genes app psen1 and psen2 in families with autosomal dominant early onset ad eoad gene discovery in familial eoad came more or less to a standstill only 5 of eoad patients are carrying a pathogenic mutation in one of the ad genes or a apoe risk allele ε4 most of eoad patients remain unexplained here we aimed at summarizing the current knowledge of eoad genetics and its role in ongoing approaches to understand the biology of ad and disease symptomatology as well as developing new therapeutics next we explored the possible molecular mechanisms that might underlie the missing genetic etiology of eoad and discussed how the use of massive parallel sequencing technologies triggered novel gene discoveries to conclude we commented on the relevance of reinvestigating eoad patients as a means to explore potential new avenues for translational research and therapeutic discoveries alzheimers dement 2016 mar 23 pii s1552 5260 16 00079 0 doi http dx doi org 10 1016 j jalz 2016 01 012 molecular genetics of early onset alzheimer disease revisited cacace r 1 sleegers k 1 van broeckhoven c 2 1 neurodegenerative brain diseases group department of molecular genetics vib antwerp belgium laboratory of neurogenetics institute born bunge university of antwerp antwerp belgium 2 neurodegenerative brain diseases group department of molecular genetics vib antwerp belgium laboratory of neurogenetics institute born bunge university of antwerp antwerp belgium electronic address christine vanbroeckhoven molgen vib ua be leave a comment filed under ageing ageing brain aging alzheimer disease alzheimer s disease dementia gerontology tagged as ageing aging alzheim alzheimer disease apoe app biogerontology brain dementia early onset alzheimer disease elderly eoad genetics gerontology late onset alzheimer disease load molecular genetics old people science march 13 2016 8 47 pm protective effects of sirtuins a recent review highlights the protective effects of sirtuins in cardiovascular disease sirtuins sirt1 sirt7 comprise a family of nicotinamide adenine dinucleotide nad dependent enzymes while deacetylation reflects their main task some of them have deacylase adenosine diphosphate ribosylase demalonylase glutarylase and desuccinylase properties activated upon caloric restriction and exercise they control critical cellular processes in the nucleus cytoplasm and mitochondria to maintain metabolic homeostasis reduce cellular damage and dampen inflammation all of which serve to protect against a variety of age related diseases including cardiovascular pathologies this review focuses on the cardiovascular effects of sirt1 sirt3 sirt6 and sirt7 sirt1 protects from endothelial dysfunction atherothrombosis diet induced obesity type 2 diabetes liver steatosis and myocardial infarction sirt3 provides beneficial effects in the context of left ventricular hypertrophy cardiomyopathy oxidative stress metabolic homeostasis and dyslipidaemia sirt6 is implicated in ameliorating dyslipidaemia cellular senescence and left ventricular hypertrophy sirt7 plays a role in lipid metabolism and cardiomyopathies eur heart j 2015 dec 21 36 48 3404 12 doi 10 1093 eurheartj ehv290 epub 2015 jun 25 protective effects of sirtuins in cardiovascular diseases from bench to bedside winnik s auwerx j sinclair da matter cm 1 comment filed under ageing aging cardiovascular disease deacetylase sirtuin tagged as ageing aging cardiovascular disease deacetylase sirtuin february 23 2016 2 12 am sightlines the sightlines project investigates how well americans are doing in each of the three areas that are critical to well being as people age financial security social engagement and healthy living do the trends over the last 15 years bode well or do they raise concerns regarding our capacity to thrive as individuals and as a nation the findings are based on analyses of eight nationally representative high quality multi year studies over two decades involving more than 1 2 million americans the learnings are intended to stir national debate guide policy development stimulate entrepreneurial innovation and encourage personal choices that enhance independent 100 year lives key findings healthy living defined as avoiding risky behaviors smoking excessive drinking drug use etc and making healthy choices day to day eating well exercising etc is known to be beneficial americans have made substantial progress in several areas while others challenges remain or have actually increased most surprising smoking the top preventable cause of morbidity and early mortality is declining in every age group for the first time in decades more americans are exercising regularly more than half of millennials ages 25 34 are getting the recommended amount of exercise sitting which has emerged as an independent risk factor for health is steeply increasing problems with diet and sleep are widespread and show no signs of abating financial security across the life span is a growing challenge for longer lives financial security has deteriorated from 2000 to 2014 particularly among the least educated who are more likely to live at or near poverty lack emergency resources and are less likely to invest in their financial futures most surprising a 15 year decline in health insurance coverage among the most vulnerable those without high school education has reversed since the implementation of the affordable care act decreasing the likelihood that the financial security of those in this group will be decimated by a health event millennials adults ages 25 to 34 are facing uphill struggles the incomes of the less educated are often at or near poverty levels while those who went to college are 50 more likely to carry debt and the average debt in this group is 5 times higher than their predecessors carried just 15 years ago fewer americans two out of three establish retirement savings plans before age 55 among those who are ineligible for employer based plans only one in three is participating in a plan social engagement central to long and healthy lives includes both meaningful relationships and participation in communities social engagement is declining along many traditional indicators it is too soon to tell whether new forms of technology mediated social engagement sms chat facetime posting and tweeting are providing social benefits and how they complement face to face engagement most surprising with the exception of 35 44 year olds community engagement has declined interactions with neighbors who represent physically accessible and often helpful relationships are becoming less common compared to their counterparts only 20 years ago members of the baby boom generation are less likely to be married have weaker ties to family friends and neighbors and are less likely to engage in religious or community activities longer lives mean that marriages survive as well fifty three percent of americans over 75 are married up from 42 percent in 2003 http sightlinesproject stanford edu overview html leave a comment filed under ageing ageing population ageing research ageing statistics ageing studies aging aging population aging research als baby boomer baby boomers biogerontology charities default retirement age economics elderly elderly care global ageing global aging growing old lifespan longevity old age old people old population science science of ageing tagged as ageing aging elderly healthspan lifespan living longer old age old people retirement older posts archives december 2017 august 2017 september 2016 july 2016 june 2016 may 2016 april 2016 march 2016 february 2016 january 2016 december 2015 september 2015 february 2015 january 2015 august 2014 july 2014 june 2014 september 2013 august 2013 june 2013 april 2013 december 2012 november 2012 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ireland cell center for science and policy cambridge centre for policy on ageing current biology current opinion in cell biology cystolith deary group edinburgh dillin lab salk dna repair dna research doherty group sussex dunn walters group kcl eldis ageing entrez era age evans group salk experimental gerontology famling faragher group brighton fertility and sterility flannotator flies and bikes flybase flyexpress francis west group king s gage lab salk gems group ucl genes development genetics genetics society glenn labs global action on aging greig group edinburgh healthy lifespan institute helpage international henderson group cambridge hetzer lab salk hickson group oxford hubmed human molecular genetics human reproduction iahsa blog immunity ageing institute for ageing and health newcastle institute of gerontology king s international association of gerontology and geriatrics international federation of fertility societies international institute on ageing international longevity centre international society for aging and physical activity international society for computational biology jackson and mcardle group liverpool jeggo group sussex joao pedro de magalhaes jones lab salk journal of heredity jove juan carlos izpisua belmonte judith campisi kaina group mainz kapahi group buck karlseder lab salk keith caldecott kenyon lab ucsf khaw group cambridge ki aging rsearch center kipling group cardiff kirkwood group newcastle lehmannn group sussex leibniz institute for age research fritz lipmann institute levy group inserm lithgow group buck lord group birmingham lundblad group salk lynne cox oxford markus christmann martin brand max planck institute for biology of ageing mechanisms of ageing and development mhr basic science of reproductive medicine mit glenn lab molecular biology and evolution monnat group washington mrc mitochondria murray group sussex mutagenesis national center for biotechnology information nature neurobiology of aging new dynamics new scientist nuclei acids research o driscoll group sussex ouroboros oxford institute of ageing partridge group ucl physiology society pimm plos computational biology plos genetics proceedings of the national academy of sciences public library of science raphide rejuvenation research reproduction fertility and development research into ageing richard aspinall richardson group bangor roos group mainz salk institute glenn center for aging research saunders group open science science of aging knowledge environment sherratt group manchester society for endocrinology strategic promotion of ageing research capacity strategies for engineered negligible senescence sussex gdsc terence davis cardiff the biochemical society the british society for cell biology the embo journal the genetics society uk thornton group embl ebi ucl institute for healthy ageing uk age research forum uk pubmed central un escap sdd venien bryan group oxford vijg group yeshiva vilhelm bohr von zglinicki group newcastle well being insitute cambridge who ageing wordpre...